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525022 Aldrich

4-Aminoindole

97%

Synonym: (Indol-4-yl)amine, 4-Indolamine

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Properties

Related Categories Building Blocks, C7 to C9, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
InChI Key   LUNUNJFSHKSXGQ-UHFFFAOYSA-N
assay   97%
mp   106-109 °C(lit.)

Description

Packaging

500 mg in glass bottle

Application

4-Aminoindole may be used to synthesize:
• macrolactam tumour promoter indolactam V
• tricyclic structure of 2-substituted-pyrrolo[2,3-h]quinolin-4-one
• 4-azidoindole

Reactant for preparation of:
• Inhibitors of bacterial thymidylate synthase
• Mimetics of non-alkaloid toxin lignan anticancer and antiviral agent Podophyllotoxin (PPT)
• Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
• Protein kinase C θ (PKCθ) inhibitors
• Indolic non-peptidic HIV protease inhibitors
• Transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists
• Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors
• 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors
• Short chain 4-substituted indoles as potent αvβ3 antagonist
• Ligands of serotonin transporter and 5-HT1A receptors

General description

4-Aminoindole is an indole derivative. Its cytokinin activity has been assessed by tobacco pith callus bioassay. 4-Aminoindole can be prepared by reacting 2,6-dinitrotoluene and N,N-dimethylformamide dimethylacetal in anhydrous DMF.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Related Content

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

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