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532290 Aldrich

2-Chlorotrityl chloride, polymer-bound

200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl loading, 1 % cross-linked

Synonym: 2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Peptide Chemistry, Polymer Supports for SPPS, Resins for Fmoc-/tBu-SPPS,
InChI Key   JFLSOKIMYBSASW-UHFFFAOYSA-N
crosslinking   1 % cross-linked
extent of labeling   1.0-1.5 mmol/g Cl loading
particle size   200-400 mesh

Description

Packaging

1, 5 g in glass bottle

Application

• Acid labile resin used in Fmoc-based solid phase peptide synthesis.
• Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
• 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
• This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences.

Use:
• Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
• Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
• Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
• If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Related Products

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