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533254 Aldrich

2-Fluoro-4-methylpyridine

98%

Synonym: 2-Fluoro-4-picoline

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Properties

Related Categories Building Blocks, C6, Chemical Synthesis, Fluorinated Building Blocks, Heterocyclic Building Blocks,
InChI Key   ZBFAXMKJADVOGH-UHFFFAOYSA-N
assay   98%
refractive index   n20/D 1.472(lit.)
bp   160-161 °C(lit.)
density   1.078 g/mL at 25 °C(lit.)

Description

Packaging

1 g in glass bottle

Application

2-Fluoro-4-methylpyridine may be used in the preparation of:
• 2-Fluoro-4-(iodomethyl)pyridine
• 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydroimidazol-2-thione
• 2-fluoro-4-pyridinemethanol
• 2-fluoro-4-pyridinemethanol, 4-methylbenzenesulfonate
• 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
• 2-fluoro-3-iodo-5-methylpyridine
• 2-fluoro-4-pyridinecarboxylic acid

General description

2-Fluoro-4-methylpyridine, also known as 2-fluoro-4-picoline, can be prepared based on Talik′s procedure from 2-amino-5-methylpyridine via diazotization. The effect of substituents on spectral properties of 2-fluoro-6-methylpyridine has been investigated based on 13C NMR, UV and IR spectral data.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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