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54802 Aldrich

1-Hydroxybenzotriazole hydrate

≥97.0% (T)

Synonym: HOBt Hydrate

  • CAS Number 123333-53-9

  • Empirical Formula (Hill Notation) C6H5N3O · xH2O

  • Molecular Weight 135.12 (anhydrous basis)

  •  Beilstein Registry Number 4515

  •  EC Number 219-989-7

  •  MDL number MFCD00065690

  •  PubChem Substance ID 24879005

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Properties

Related Categories Active Esters/Additives, Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry,
InChI Key   PJUPKRYGDFTMTM-UHFFFAOYSA-N
assay   ≥97.0% (T)
impurities   ~12% water
mp   155-158 °C(lit.)
solubility   DMF: soluble0.1 g/mL, clear

Description

Other Notes

Widely used additive to decrease racemization in the carbodiimide peptide coupling; Racemization-free condensation of peptide fragments

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Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Warning
Hazard statements 
Precautionary statements 
Supplemental Hazard Statements 
Explosive when dry., Risk of explosion if heated under confinement.
RIDADR 
UN3474 - class 4.1 - PG 1 - 1-Hydroxybenzotriazole, monohydrate
WGK Germany 
nwg
Protocols & Articles

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Peer-Reviewed Papers
15

References

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