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564990 Aldrich

N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine

Synonym: Ishikawa’s Reagent

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Properties

Related Categories Chemical Synthesis, Fluorination, Fluorination Reagents, Synthetic Reagents
InChI Key   BNTFCVMJHBNJAR-UHFFFAOYSA-N
refractive index   n20/D 1.3460(lit.)
bp   56-57 °C(lit.)
density   1.230 g/mL at 25 °C(lit.)

Description

Application

Demonstrates utility in fluorination.

Displays the ability to insert a fluoro(trifluoromethyl) methylene moiety in unsaturated alcohols.

Reactant for:
• Friedel-Crafts type arylation of hydrofluorocarbons
• Microbial hydroxylation of antibiotics
• Electrochemical fluorination of trialkylamines and tetraalkylammonium salts
• Fluorination of pyrethroides

Reactant for synthesis of:
• γ-Hydroxy-α-fluoro-α-trifluoromethylcarboxamide
• Florfenicol and thiamphenicol

Packaging

25 g in glass bottle

General description

GC analysis includes Et2NCF=CFCF3 (two isomers), both of which are active fluorinating agents.

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2920 3(8) / PGII
WGK Germany 
3
Flash Point(F) 
104 °F
Flash Point(C) 
40 °C
Protocols & Articles

Articles

Reagents for Fluorination

The trifluoromethyl substituent has long been recognized for the positive influence it can have on the biological activity of molecules. Professor William Dolbier, Jr. (University of Florida) has dev...
Aldrich ChemFiles 2007, 7.1, 11.

Peer-Reviewed Papers
15

References

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