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Metathesis: Ruthenium-Based Metathesis Catalysts
Catalyst for ring-closing metathesis, cross metathesis and ROMP1 able to produce trisubstituted olefins via cross metathesis,8 and ring closes olefins with excellent functional group tolerance and selectivity.9
Grubbs 2nd Generation Catalyst
Generally more active compared to 1st generation catalysts and with a broader substrate scope, including sterically demanding or deactivated olefins such as 1,1-disubstituted olefins and α,β-unsaturated carbonyls.1,2,3,4,5,6,7
NO BULK ORDERS
100, 500 mg in glass bottle
2 g in glass bottle
US Patent No. 6,111,121 and 7,329,758 (and associated foreign equivalents of the foregoing) apply. Sale of this product conveys to the buyer a limited-use research license. For full details of this license please see sigma-aldrich.com/materia
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Enyne metathesis has emerged as a powerful method for the synthesis of conjugated dienes.1 Botta and coworkers utilized a similar approach, where the olefin was replaced with an enol ether. Reaction ...
Aldrich ChemFiles 2009, 9.6, 7.
Keywords: Enyne metathesis, Metathesis, Microwave synthesis
Ring-closing metathesis has become an essential tool for C-C bond formation as demonstrated by the profound impact on total synthesis in recent years.1 The first examples date back to 1980 and involv...
Aldrich ChemFiles 2009,9.6, 4.
Keywords: C-C bond formation, Cyclizations, Metathesis, Ring-closing metathesis
Sigma-Aldrich is pleased to announce an agreement with Materia, Inc. to exclusively distribute research quantities of Grubbs catalysts and Hoveyda–Grubbs catalysts. For a recent review on cross-metat...
ChemFiles Volume 4 Article 2
Keywords: Cross metathesis, Metathesis, Organic synthesis, Ring opening metathesis polymerisation, Ring-closing metathesis
Donohoe and co-workers have developed several synthetic approaches to the synthesis of furans which incorporate RCM as a key step.1 In 2007, the researchers synthesized a series of di- and tri-substi...
Aldrich ChemFiles 2009,9.6, 5.
Keywords: Anti-inflammatory agents
Olefin metathesis is now a well-entrenched synthetic technique, and is a powerful method for the clean construction of innumerable classes of chemical architectures. The broadly accepted belief that ...
Keywords: Building blocks, Cross metathesis, Enyne metathesis, Exothermic, Isomerizations, Ligands, Living polymerization, Metathesis, Olefin metathesis, Organic synthesis, Polymerization reactions, Ring opening metathesis polymerisation, Ring-closing metathesis
2. Grubbs, R. H. Tetrahedron 60, 7117, (2004)
3. Schrodi, Y.; Pederson, R. L. Aldrichimica Acta 40th ed.,, 45, (2007)
6. Schuster, M.; Blechert, S. Angew. Chem. Int. Ed. Engl. 36th ed.,, 2036, (1997)
7. Ritter, T., et al. Organometallics 25th ed.,, 5740, (2006)
8. Org. Lett. 1, 751, (1999)
Highly Efficient Ring-Opening Metathesis Polymerization (ROMP) Using New Ruthenium Catalysts Containing N-Heterocyclic Carbene Ligands C.B. is grateful to the National Science Foundation for a pre-doctoral fellowship. The authors thank Dr. Matthias Scholl for providing catalysts 4 a and 4 c. Bielawski, C. W.; Grubbs, R. H. Angew. Chem. Int. Ed. Engl. 39, 2903, (2000)
Scholl, M. Acc. Chem. Res. 1, 953, (1999)
Tetrahedron 62, 9017, (2006)
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