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572667 Aldrich

Baicalin

95%

Synonym: 5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid, Baicalein 7-O-β-D-glucuronide

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Properties

Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Complex Molecules
assay   95%
form   solid
optical activity   [α]20/D −85°, c = 1 in DMSO
mp   202-205 °C (dec.)(lit.)
Gene Information   mouse ... Hexa(15211)

Description

Packaging

1 g in glass bottle

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling. Knapp K, Zebisch M, Pippel J, et al. Structure 20(12), 2161-73, (2012)

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[The study on baicalin in China]. Zhu Y Zhongguo Zhong Xi Yi Jie He Za Zhi 13(9), 567-9, (1993)

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Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia. Li B, Wan L, Li Y, et al. Tumour Biol. 35(12), 12415-25, (2014)

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Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Ding Y, Dou J, Teng Z, et al. Arch. Virol. 159(12), 3269-78, (2014)

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[Protective effect of baicalin against LPS-induced intestinal injury]. Wu Q, Ye H, Zhu YZ, et al. Zhongguo Zhong Yao Za Zhi 38(17), 2854-8, (2013)

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[Effect of baicalin on pattern recognition receptor TLR2/4-NOD2 and its significance of druggability]. Chai YS, Lei F, Xing DM, et al. Zhongguo Zhong Yao Za Zhi 38(16), 2639-44, (2013)

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Rapid determination of baicalin and total baicalein content in Scutellariae radix by ATR-IR and NIR spectroscopy. Navarro Escamilla M, Rodenas Sanz F, Li H, et al. Talanta 114, 304-10, (2013)

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[Effect of baicalin on expression of TLR4 in RAW264.7 cells infected by ESBLs Escherichia coli]. Yun Y, Wang CZ, Gui L, et al. Zhongguo Zhong Yao Za Zhi 38(10), 1590-4, (2013)

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[Preparation of baicalin nanocrystal pellets and preliminary study on its pharmacokinetics]. Jin SY, Yuan HL, Jin SX, et al. Zhongguo Zhong Yao Za Zhi 38(8), 1156-9, (2013)

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A stable fixed-dose combination tablet of pseudoephedrine and KOB extracts for the extended release. Hwang CJ, Park MH, Jung HW, et al. Drug Res. (Stuttg.) 63(11), 572-8, (2013)

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[Determination of chlorogenic acid and baicalin in Yinhuang film-coated tablets by HPLC isocratic elution]. Xu M, Yuan Q, Zhao H, et al. Zhongguo Zhong Yao Za Zhi 38(5), 691-3, (2013)

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[Study on in situ intestinal absorption of baicalin contained in Tiangou Jiangya capsules]. Li LJ, Li J, and Lou HW Zhongguo Zhong Yao Za Zhi 38(6), 894-8, (2013)

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[Antitumor effect of baicalin on rat brain glioma]. Hu YZ, Wang DH, Luan Y, et al. Zhonghua Zhong Liu Za Zhi 35(1), 11-6, (2013)

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[Effect on different concentrations of exogenous hormones on baicalin in Scutellaria baicalensis callus]. Wan GX, Ma L, and Zhang J Zhongguo Zhong Yao Za Zhi 37(24), 3799-802, (2012)

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[Effect of different developmental stage on plant growth and active compounds in Scutellaria baicalensis]. Hu GQ, Yuan Y, Wu C, et al. Zhongguo Zhong Yao Za Zhi 37(24), 3793-8, (2012)

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[Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells]. Zhang BS, An R, Wang Y, et al. Zhong Yao Cai 35(9), 1460-3, (2012)

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[Optimization of the extraction process for qingrejiedu oral liquid with synthesizing multiple guidelines grading method]. Liu H, Zhang ZW, and Ji ZQ Zhong Yao Cai 35(8), 1326-30, (2012)

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[In vitro effect of banxiaxiexin-decoction and different combinations on the metabolic activities of baicalin and baicalein in rat liver microsomes]. Cai QL, Wang Y, Cui B, et al. Zhong Yao Cai 35(8), 1286-90, (2012)

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[Construction on the chitosan microparticles of baicalin and comparison of transdermal diffusion in vitro of baicalin in chitosan microparticles and cream]. Wang H, Cai Y, Han H, et al. Zhong Yao Cai 35(5), 800-3, (2012)

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[Drug delivery systems of baicalin, baicalin-phospholipid complex and self-microemulsifying drug across Caco-2 cell model]. Chen L, Long XY, Huang SH, et al. Zhong Yao Cai 35(5), 757-61, (2012)

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[Preparation of flavonoid reference standards from Scutellariae Radix under the guidance of high performance liquid chromatography-mass spectrometry analysis]. Guo H, Yang X, Liu J, et al. Se Pu 30(7), 690-5, (2012)

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New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Li-Weber M Cancer Treat. Rev. 35(1), 57-68, (2009)

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Baicalin regulates neuronal fate decision in neural stem/progenitor cells and stimulates hippocampal neurogenesis in adult rats. Zhuang PW, Cui GZ, Zhang YJ, et al. CNS Neurosci. Ther. 19(3), 154-62, (2013)

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Concentration-dependent inhibitory effect of Baicalin on the plasma protein binding and metabolism of chlorzoxazone, a CYP2E1 probe substrate, in rats in vitro and in vivo. Gao N, Zou D, and Qiao HL PLoS ONE 8(1), e53038, (2013)

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Concentration-dependent inhibitory effects of baicalin on the metabolism of dextromethorphan, a dual probe of CYP2D and CYP3A, in rats. Tian X, Cheng ZY, He J, et al. Chem. Biol. Interact. 203(2), 522-9, (2013)

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Inhibitory effect of the Baicalin on collagen-induced arthritis in rats through nuclear factor kappa B pathway. Wang H, Wang H, Huang S, et al. J. Pharmacol. Exp. Ther., (2014)

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D-Alpha-tocopherol acid polyethylene glycol 1000 succinate, an effective stabilizer during solidification transformation of baicalin nanosuspensions. Yue PF, Wan J, Wang Y, et al. Int. J. Pharm. 443(1-2), 279-87, (2013)

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Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Srinivas NR Xenobiotica 40(5), 357-67, (2010)

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Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats. Wang Z, Hu H, Chen F, et al. J. Ethnopharmacol. 145(2), 442-9, (2013)

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Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Wang CZ, Calway TD, Wen XD, et al. Int. J. Oncol. 42(3), 1018-26, (2013)

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Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies. Chen H, Gao Y, Wu J, et al. Cancer Lett. 354(1), 5-11, (2014)

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AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells. Lin C, Tsai SC, Tseng MT, et al. Int. J. Oncol. 42(3), 993-1000, (2013)

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Baicalin downregulates Porphyromonas gingivalis lipopolysaccharide-upregulated IL-6 and IL-8 expression in human oral keratinocytes by negative regulation of TLR signaling. Luo W, Wang CY, and Jin L PLoS ONE 7(12), e51008, (2012)

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Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract. Deng YX, Shi QZ, Chen B, et al. Fitoterapia 83(8), 1435-42, (2012)

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Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats. Zhang J, Li P, Wang Y, et al. PLoS ONE 8(2), e56658, (2013)

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Identification of a nitric oxide generation-stimulative principle in Scutellariae radix. Chen Z, Nihei K, Tanaka H, et al. Biosci. Biotechnol. Biochem. 77(3), 657-9, (2013)

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Baicalin as a potentially promising drug for the management of sulfur mustard induced cutaneous complications: a review of molecular mechanisms. Sahebkar A Cutan. Ocul. Toxicol. 31(3), 226-34, (2012)

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Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: correlation with scavenging free radical. Wang S, Zang W, Yang Y, et al. Environ. Toxicol. Pharmacol. 36(2), 403-10, (2013)

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Biotransformation of baicalin to baicalein significantly strengthens the inhibition potential towards UDP-glucuronosyltransferases (UGTs) isoforms. Teng Y, Nian H, Zhao H, et al. Pharmazie 68(9), 763-7, (2013)

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The effects of coenzyme Q10 and baicalin in cisplatin-induced lipid peroxidation and nitrosative stress. Sawicka E, Długosz A, Rembacz KP, et al. Acta Pol. Pharm. 70(6), 977-85, (2013)

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