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574791 Aldrich

Hydroxyapatite

synthetic, ≥99.995% trace metals basis

Synonym: Calcium hydroxyphosphate, Calcium phosphate tribasic, HAp, Hydroxylapatite, Tribasic calcium phosphate

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Description

Packaging

5, 15 g in glass bottle

Protocols & Applications

Bone Tissue Engineering Based on Calcium Phosphate Ceramics

Price and Availability


Ultra-high Purity Salts

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Hydroxyapatite

nanoparticles, dispersion, 10 wt. % in H2O, <200 nm particle size (BET)

Hydroxyapatite

′high resolution′

Hydroxyapatite

puriss., meets analytical specification of Ph. Eur., BP, FCC, E341, ≥90% (calculated on glowed substance)

Hydroxyapatite

purum p.a., ≥90% (as Ca3(PO4)2, KT)

Hydroxyapatite

reagent grade, powder, synthetic

Safety & Documentation

Safety Information

Personal Protective Equipment 
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in Calcium phosphate tribasic Using Karl Fischer Titration

Adherent water in salts can be easily determined. It is best to choose a working medium which will prevent the salt from dissolving, e.g. a Methanol-Chloroform mixture with an excess of Chloroform. T...
Keywords: Crystallization, Titrations

Electrospinning: An Enabling Technique for Nanostructured Materials

Fibrous nanomaterials are attractive for a range of applications due to their intrinsically high porosities and large surface areas. Electrospinning is a simple, versatile technique for generating na...
Dr. Jingwei Xie and Prof. Younan Xia
Material Matters 2008, 3.1, 19.
Keywords: Applications, Biomaterials, Capabilities, Cell biology, Central Nervous System, Ceramics, Compliance, Evaporation, Growth factors, Methods, Nanomaterials, Nanotechnology, Nanotubes, Separation, Sol-gel, Stem cell biology, Tools, Type

Peer-Reviewed Papers

References

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Transient amorphous calcium phosphate in forming enamel. Elia Beniash et al J. Struct. Biol. 166, 133-43, (2009)

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Deproteinized bovine bone functionalized with the slow delivery of BMP-2 for the repair of critical-sized bone defects in sheep. Liu T, Wu G, Wismeijer D, et al. Bone 56(1), 110-8, (2013)

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Citrate occurs widely in healthy and pathological apatitic biomineral: mineralized articular cartilage, and intimal atherosclerotic plaque and apatitic kidney stones. Reid DG, Duer MJ, Jackson GE, et al. Calcif. Tissue Int. 93(3), 253-60, (2013)

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Inhibition of osteoclastogenesis by osteoblast-like cells genetically engineered to produce interleukin-10. Fujioka K, Kishida T, Ejima A, et al. Biochem. Biophys. Res. Commun. 456(3), 785-91, (2015)

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Secondarily infected nonstruvite urolithiasis: a prospective evaluation. de Cógáin MR, Lieske JC, Vrtiska TJ, et al. Urology 84(6), 1295-300, (2014)

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Porous titanium particles for acetabular reconstruction in total hip replacement show extensive bony armoring after 15 weeks. A loaded in vivo study in 10 goats. Walschot LH, Aquarius R, Verdonschot N, et al. Acta Orthop. 85(6), 600-8, (2014)

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Polymer nanocarriers for dentin adhesion. Osorio R, Osorio E, Medina-Castillo AL, et al. J. Dent. Res. 93(12), 1258-63, (2014)

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The use of calcium phosphate cement in vertebroplasty of the base of odontoid process. Zapałowicz K, Wojdyn M, Zieliński KW, et al. Neurol. Neurochir. Pol. 47(6), 590-4, (2013)

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A mini review of biodegradable calcium phosphate nanoparticles for gene delivery. Xie Y, Chen Y, Sun M, et al. Curr. Pharm. Biotechnol. 14(10), 918-25, (2013)

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An injectable BMP cocktail for fracture-healing--a study that others have only imagined: commentary on an article by Thomas Lyon, MD, et al.: "Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture. a double-blind, randomized, controlled phase-II/III trial". Collinge C J. Bone Joint Surg. Am. 95(23), e1891-2, (2013)

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Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture: a double-blind, randomized, controlled phase-II/III trial. Lyon T, Scheele W, Bhandari M, et al. J. Bone Joint Surg. Am. 95(23), 2088-96, (2013)

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The effect of amorphous pyrophosphate on calcium phosphate cement resorption and bone generation. Grover LM, Wright AJ, Gbureck U, et al. Biomaterials 34(28), 6631-7, (2013)

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Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. Yao J, Zhang Y, Ramishetti S, et al. J. Control. Release 170(3), 414-20, (2013)

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Reprogramming of mesenchymal stem cells derived from iPSCs seeded on biofunctionalized calcium phosphate scaffold for bone engineering. Liu J, Chen W, Zhao Z, et al. Biomaterials 34(32), 7862-72, (2013)

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Chitosan-hydroxyapatite composites. Pighinelli L and Kucharska M Carbohydr. Polym. 93(1), 256-62, (2013)

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ox-LDL induces PiT-1 expression in human aortic valve interstitial cells. Nadlonek NA, Lee JH, Weyant MJ, et al. J. Surg. Res. 184(1), 6-9, (2013)

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Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics. Ehud Segal et al PLoS ONE 4, e5233, (2009)

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Comparison of the use of adipose tissue-derived and bone marrow-derived stem cells for rapid bone regeneration. Zhang W, Zhang X, Wang S, et al. J. Dent. Res. 92(12), 1136-41, (2013)

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Improved biocompatibility of poly(lactic-co-glycolic acid) orv and poly-L-lactic acid blended with nanoparticulate amorphous calcium phosphate in vascular stent applications. Zheng X, Wang Y, Lan Z, et al. J. Biomed. Nanotechnol. 10(6), 900-10, (2014)

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Multifunctional calcium phosphate nano-contrast agent for combined nuclear, magnetic and near-infrared in vivo imaging. Ashokan A, Gowd GS, Somasundaram VH, et al. Biomaterials 34(29), 7143-57, (2013)

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The characteristics of the stone and urine composition in Chinese stone formers: primary report of a single-center results. Wu W, Yang D, Tiselius HG, et al. Urology 83(4), 732-7, (2014)

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Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior. Samavedi S, Whittington AR, and Goldstein AS Acta Biomater. 9(9), 8037-45, (2013)

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A microwave-assisted solution combustion synthesis to produce europium-doped calcium phosphate nanowhiskers for bioimaging applications. Wagner DE, Eisenmann KM, Nestor-Kalinoski AL, et al. Acta Biomater. 9(9), 8422-32, (2013)

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Using 24-hour urinalysis to predict stone type. Moreira DM, Friedlander JI, Hartman C, et al. J. Urol. 190(6), 2106-11, (2013)

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Efficacy of a supersaturated calcium phosphate oral rinse for the prevention and treatment of oral mucositis in patients receiving high-dose cancer therapy: a review of current data. Quinn B Eur. J. Cancer Care (Engl.) 22(5), 564-79, (2013)

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Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold. Farokhi M, Mottaghitalab F, Ai J, et al. Int. J. Pharm. 454(1), 216-25, (2013)

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Incorporation of biphasic calcium phosphate microparticles in injectable thermoresponsive hydrogel modulates bone cell proliferation and differentiation. Chen JP, Tsai MJ, and Liao HT Colloids Surf. B Biointerfaces 110, 120-9, (2013)

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Autophagy induced by calcium phosphate precipitates targets damaged endosomes. Chen X, Khambu B, Zhang H, et al. J. Biol. Chem. 289(16), 11162-74, (2014)

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Chemical composition and binary mixture of human urinary stones using FT-Raman spectroscopy method. Selvaraju R, Raja A, and Thiruppathi G Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114, 650-7, (2013)

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Enhanced NIR downconversion luminescence by precipitating nano Ca5(PO4)3F crystals in Eu2+-Yb3+ co-doped glass. Li C, Song Z, Li Y, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114, 575-8, (2013)

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Microwave assisted preparation of magnesium phosphate cement (MPC) for orthopedic applications: a novel solution to the exothermicity problem. Zhou H, Agarwal AK, Goel VK, et al. Mater. Sci. Eng. C. Mater. Biol. Appl. 33(7), 4288-94, (2013)

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Pulsed electrodeposition for the synthesis of strontium-substituted calcium phosphate coatings with improved dissolution properties. Drevet R and Benhayoune H Mater. Sci. Eng. C. Mater. Biol. Appl. 33(7), 4260-5, (2013)

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Preparation, characterization, biological activity, and transport study of polystyrene based calcium-barium phosphate composite membrane. Khan MM and Rafiuddin Mater. Sci. Eng. C. Mater. Biol. Appl. 33(7), 4228-35, (2013)

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Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics. Simão AM, Bolean M, Hoylaerts MF, et al. Calcif. Tissue Int. 93(3), 222-32, (2013)

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Effects of different dosages of parathyroid hormone-related protein 1-34 on the bone metabolism of the ovariectomized rat model of osteoporosis. Xu J, Rong H, Ji H, et al. Calcif. Tissue Int. 93(3), 276-87, (2013)

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Chitosan Fibers Modified with HAp/β-TCP Nanoparticles. Dariusz Wawro et al Int. J. Mol. Sci. 12, 7286-300, (2011)

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The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. Vono M, Taccone M, Caccin P, et al. Proc. Natl. Acad. Sci. U. S. A. 110(52), 21095-100, (2013)

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Age-dependent association between Dickkopf-1 and calcium-containing urolithiasis. Jou YC, Tsai YS, Hsieh HY, et al. Urology 83(5), 1006-10, (2014)

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Merck 14,3467

Corp MSDS 1 (1), 670:A / FT-IR 2 (3), 4742:A / FT-IR 1 (2), 1267:C / RegBook 1 (3), 3425:C

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