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64275 Aldrich

Methanesulfonamide

≥97.0% (CHN)

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonamides/Sulfinamides, Sulfur Compounds More...
assay   ≥97.0% (CHN)
mp   85-89 °C(lit.)

Description

Packaging

10, 50 g in glass bottle

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide. Karakuş S, Güniz Küçükgüzel S, Küçükgüzel I, et al. Eur. J. Med. Chem. 44(9), 3591-5, (2009)

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In vitro antitumor mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide. Lu T, Laughton CA, Wang S, et al. Mol. Pharmacol. 87(1), 18-30, (2015)

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Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity. Lemaire G, Benod C, Nahoum V, et al. Mol. Pharmacol. 72(3), 572-81, (2007)

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Mild Pd-catalyzed N-arylation of methanesulfonamide and related nucleophiles: avoiding potentially genotoxic reagents and byproducts. Rosen BR, Ruble JC, Beauchamp TJ, et al. Org. Lett. 13(10), 2564-7, (2011)

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Regulation of macrophage eicosanoid generation is dependent on nuclear factor κB. Lo, C.J., et al. J. Trauma 45, 19-24, (1998)

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Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents. Alka Bali et al Eur. J. Med. Chem. 49C, 397-405, (2012)

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A new class of carbonic anhydrase inhibitor. Maren TH and Conroy CW J. Biol. Chem. 268(35), 26233-9, (1993)

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Total synthesis of a marine alkaloid--rigidin E. Cao B, Ding H, Yang R, et al. Mar. Drugs 10(6), 1412-21, (2012)

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Synthesis, anticancer, and anti-inflammatory activity evaluation of methanesulfonamide and amidine derivatives of 3,4-diaryl-2-imino-4-thiazolines. Sondhi SM, Rani R, Gupta PP, et al. Mol. Divers. 13(3), 357-66, (2009)

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Conformational analysis, vibrational and NMR spectroscopic study of the methanesulfonamide-N,N'-1,2-ethanediylbis. Alyar H, Ünal A, Özbek N, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 91, 39-47, (2012)

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An experimental and theoretical study of dipole moments of N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulfonamide. Nowak K and Wysocki S Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 70(4), 805-10, (2008)

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Synthesis and pharmacological evaluation of N,N-di-n-propyldopamine congeners containing phenolic bioisosteres. Clark RD, Caroon JM, Isaac NE, et al. J. Pharm. Sci. 76(5), 411-5, (1987)

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A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis. Grimm JB, Katcher MH, Witter DJ, et al. J. Org. Chem. 72(21), 8135-8, (2007)

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Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors. Singh SK, Vobbalareddy S, Shivaramakrishna S, et al. Bioorg. Med. Chem. Lett. 14(7), 1683-8, (2004)

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Metabolism of the prostaglandin fertility regulator sulprostone in monkeys. Falkner FC Prostaglandins 24(3), 341-50, (1982)

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Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities. Shoji Y, Takahashi K, Ohta M, et al. Bioorg. Med. Chem. 17(16), 6020-31, (2009)

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Development and validation of an LC-MS/MS method for determination of methanesulfonamide in human urine. Anacardio R, Mullins FG, Hannam S, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(22), 2087-92, (2009)

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Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenase. Ohara K, Kono T, Chisato N, et al. Int. J. Colorectal Dis. 18(3), 260-6, (2003)

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Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide. Lee K, Park JB, Jeon BH, et al. J. Cardiovasc. Pharmacol. 42(5), 648-55, (2003)

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Cytotoxic activity of platinum(II) and palladium(II) complexes of N-3-pyridinylmethanesulfonamide: the influence of electroporation. Dodoff NI, Iordanov I, Tsoneva I, et al. Z. Naturforsch. C 64(3-4), 179-85, (2009)

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Beil. 4,IV,28

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