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644501 Aldrich

Dichloromethane

purification grade

Synonym: Methylene chloride

  • CAS Number 75-09-2

  • Empirical Formula (Hill Notation) CH2Cl2

  • Molecular Weight 84.93

  •  Beilstein Registry Number 1730800

  •  EC Number 200-838-9

  •  MDL number MFCD00000881

  •  PubChem Substance ID 24883339

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Properties

grade   purification grade
vapor density   2.9 (vs air)
vapor pressure   24.45 psi ( 55 °C)
  6.83 psi ( 20 °C)
autoignition temp.   1223 °F
expl. lim.   22 %
evapn. residue   ≤0.0005%
refractive index   n20/D 1.424(lit.)
bp   39.8-40 °C(lit.)
mp   −97 °C(lit.)
density   1.325 g/mL at 25 °C(lit.)

Price and Availability

A Greener Alternative to Dichloromethane


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flash chromatography applications?
Consider the greener non-chlorinated alternative, Ethyl acetate/Ethanol 3:1 (v/v) solution (Cat. No. 745588).



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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Blood, Central nervous system, Liver
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
23-24/25-36/37
RIDADR 
UN 1593 6.1 / PGIII
WGK Germany 
2
RTECS 
PA8050000

Protocols & Articles

Articles

Determination of Water Content in Dichloromethane Using Karl Fischer Titration

The determination of water in halogenated hydrocarbons is simple and in most cases straightforward. Solubility in methanol is good and the use of 1-propanol or chloroform is only necessary in the cas...
Keywords: Pharmaceutical, Titrations

Determination of Water Content in Dichloromethane, free chlorine Using Karl Fischer Titration

The determination of water in halogenated hydrocarbons is simple and in most cases straightforward. Solubility in methanol is good and the use of 1-propanol or chloroform is only necessary in the cas...
Keywords: Titrations

Peer-Reviewed Papers

References

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Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane. Kumagai S, Kurumatani N, Arimoto A, et al. Occup. Environ. Med. 70(7), 508-10, (2013)

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Chiral separations by HPLC on immobilized polysaccharide chiral stationary phases. Ali I, Al-Othman ZA, and Aboul-Enein HY Methods Mol. Biol. 970, 127-35, (2013)

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[Functional analysis of the genome fragment involved in aerobic dichloromethane degradation by methylobacterium dichloromethanicum DM4]. Firsova IuE, Fedorov DN, and Trotsenko IuA Prikl. Biokhim. Mikrobiol. 48(5), 516-21, (2012)

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Activation of dichloromethane by a V(III) thiolate complex: an example of S-based nucleophilic reactivity in an early transition metal thiolate. Chen TT, Chen YS, Chang YH, et al. Chem. Commun. (Camb.) 49(11), 1109-11, (2013)

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Cytotoxic and genotoxic potential of tannery waste contaminated soils. Masood F and Malik A Sci. Total Environ. 444, 153-60, (2013)

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Biodegradation of dichloromethane along with other VOCs from pharmaceutical wastewater. Priya VS and Philip L Appl. Biochem. Biotechnol. 169(4), 1197-218, (2013)

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Insights from epidemiology into dichloromethane and cancer risk. Cooper GS, Scott CS, and Bale AS Int. J. Environ. Res. Public Health 8(8), 3380-98, (2011)

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Voltammetric determination of β-carotene in raw vegetables and berries in Triton X100 media. Ziyatdinova G, Ziganshina E, and Budnikov H Talanta 99, 1024-9, (2012)

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Critical review of the epidemiology literature on the potential cancer risks of methylene chloride. Dell LD, Mundt KA, McDonald M, et al. Int. Arch. Occup. Environ. Health 72(7), 429-42, (1999)

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Heme oxygenase 1-generated carbon monoxide and biliverdin attenuate the course of experimental necrotizing pancreatitis. Nuhn P, Mitkus T, Ceyhan GO, et al. Pancreas 42(2), 265-71, (2013)

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An analysis of OSHA inspections assessing contaminant exposures in general medical and surgical hospitals. Knight JL, Sleeth DK, Larson RR, et al. Workplace Health Saf. 61(4), 153-60, (2013)

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Multinuclear palladium(II) complexes from P-C and P-Cl bond cleavage in (R(P),R(P)/S(P),S(P))-[PdCl2{1,2-(P(t)BuCl)2C2B10H10}]. Maulana I, Lönnecke P, and Hey-Hawkins E Chem. Commun. (Camb.) 48(82), 10231-3, (2012)

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Use of dichloromethane for preparative supercritical fluid chromatographic enantioseparations. Miller L J. Chromatogr. A 1363, 323-30, (2014)

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In vitro and in vivo antileishmania activity of sesquiterpene lactone-rich dichloromethane fraction obtained from Tanacetum parthenium (L.) Schultz-Bip. Rabito MF, Britta EA, Pelegrini BL, et al. Exp. Parasitol. 143, 18-23, (2014)

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Induction of quinone reductase (QR) by withanolides isolated from Physalis pubescens L. (Solanaceae). Ji L, Yuan Y, Ma Z, et al. Steroids 78(9), 860-5, (2013)

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Optimization extraction process of aroma components in tobacco. Luo H, Cheng H, Du W, et al. J. Chromatogr. Sci. 51(3), 250-7, (2013)

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Selective extraction of berberine and palmatine from Huangbai powder. Zhou C, Li J, Tan S, et al. Pak. J. Pharm. Sci. 26(5), 1023-5, (2013)

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Application of nano-TiO2/LDPE composite film on photocatalytic oxidation degradation of dichloromethane. Suwannahong K, Liengcharernsit W, Sanongraj W, et al. J. Environ Biol. 33(5), 955-9, (2012)

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[Admissible concentration in biological material: an index of exposure to dichloromethane]. Kupczewska-Dobecka M and Soćko R Med. Pr. 59(2), 187-95, (2008)

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Merck 14,6063

Beil. 1,IV,35

Fieser 1,676 / Fieser 2,273 / Fieser 4,337 / Fieser 7,239

Aldrich MSDS 1, 621:C / Corp MSDS 1 (1), 1140:D / FT-IR 1 (1), 70:D / FT-IR 2 (1), 102:A / FT-NMR 1 (1), 105:A / IR-Spectra (2), 45:D / IR-Spectra (3), 47:E / NMR-Reference 2 (1), 72:C / RegBook 1 (1), 71:A / Sax 6, 1763 / Structure Index 1, 8:E:7 / Vapor Phase 3, 102:A

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494453 Dichloromethane, biotech. grade, 99.9%, contains 50-150 ppm amylene as stabilizer

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