Isopropylmagnesium chloride lithium chloride complex solution 1.3 M in THF

Properties

Related Categories	25mL Sure/Seal Reagents, Alkyl, Chemical Synthesis, Grignard Reagents, Organic Bases, Organometallic Reagents, Synthetic Reagents More...
concentration	1.3 M in THF
density	0.951 g/mL at 25 °C

Description

Application

Reagent used with CH₃MgCl/LiCl to affect magnesium-halogen exchange on unprotected aryl carboxylic acids.¹⁴

Reagent for Selective Metalations

Used for:
• Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones¹
• Preparation of cyclic alkenyl and dienyl magnesium reagents²
• Preparation of functionalized triazenes/preparation of carbazoles³
• Regioselective functionalization of trisubstituted pyridines⁴
• Electrophilic amination for preparation of amines⁵
• Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins)⁶
• Preparation of Benzylic Grignards via Sulfur-Magnesium exchange⁷
• Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids⁸
• Functionalization via I-Mg Exchange of unprotected imidazoles⁹
• Pyridyne formation¹⁰
• Functionalization of cyclopentene derivatives¹¹
• Preparation of 2,3-functionalized furans, benzofurans, and thiophenes¹²
• Stereoselective synthesis of substituted cyclopropanes¹³

Packaging

4×25, 100, 800 mL in Sure/Seal™

Legal Information

Product of Rockwood Lithium

Price and Availability

Related Papers

1. Stereoselective preparation of functionalized acyclic alkenylmagnesium reagents using i-PrMgCl.LiCl. Ren, H.; et al. Org. Lett. 6, 4215, (2004)

Documents

Certificate of Analysis

Certificate of Origin

ChemFiles Vol 7 No 4 (869 KB )

Safety Information

Symbol	GHS02, GHS05, GHS07
Signal word	Danger
Hazard statements	H225-H314-H335
Precautionary statements	P210-P261-P280-P305 + P351 + P338-P310
Supplemental Hazard Statements	May form explosive peroxides., Reacts violently with water.
Personal Protective Equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes (Europe)	F,C
Risk Statements (Europe)	11-14/15-19-34-37
Safety Statements (Europe)	16-26-36/37/39-43-45
RIDADR	UN 3399 4.3/PG 2
WGK Germany	3
Flash Point(F)	1.4 °F
Flash Point(C)	-17 °C

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

New Reagents for Selective Metalation, Deprotonation, and 1,2-Additions

While halogen-metal exchange reactions are among the most common methods for preparing organometallic reagents, Li-halogen exchange reactions typically require low temperatures and offer limited comp...
Dr. Josephine Nakhla
Chemfiles Volume 10 Article 1
Keywords: Addition reactions, Catalysis, Deprotonations, Eliminations, Grignard Reaction, Metallations, Nucleophilic additions, Reductions, transformation

Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl

While halogen-metal exchange reactions are among the most common methods for preparing reactive organometallic reagents, Li-halogen exchange reactions typically require low temperatures and offer lim...
Aaron Thornton
Chemfiles Volume 11 Article 1
Keywords: Eliminations, Grignard Reaction