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663131 Aldrich

RuPhos

95%

Synonym: 2-Dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl

Purchase

Properties

Related Categories Buchwald Ligands, Buchwald Ligands and Complexes, Catalysis, Catalysis and Inorganic Chemistry, Chemical Synthesis,
InChI Key   MXFYYFVVIIWKFE-UHFFFAOYSA-N
assay   95%
impurities   1-5% Bis(2′,6′-Diisopropoxybiphenyl)cyclohexylphosphine
mp   123-126 °C
ligand for   Arylations
  Buchwald-Hartwig Cross Coupling Reaction
  Negishi Coupling
  Sonogashira Coupling
  Suzuki-Miyaura Coupling

Description

Application

Bulky phosphine ligand used in a palladium-catalyzed cross-coupling of aminoethyltrifluoroborates with electron-poor aryl bromides.

Packaging

1, 5, 25, 100 g in glass bottle

Legal Information

Usage subject to US Patents 6307087 and 6395916.

Price and Availability


KitAlysis - Increasing Catalysis Productivity

Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Buchwald Phosphine Ligands - Technical Article

Over the past several years, the Buchwald group has developed a series of bulky electron-rich phosphines that have garnered much attention for their ability to effect various C–C, C–N, and C–O bond f...
Keywords: Aldrichimica Acta, Arylations, C-X bond formation, Catalysis, Chemfiles, Coupling reactions, Ligands, Methods, Type

Cross-Coupling of Mesylated Phenol Derivatives with Potassium Cyclopropyltrifluoroborate

A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catal...
Keywords: Catalysis, Chromatography, Cross couplings, Flash chromatography, Purification

Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization

The Pd-catalyzed amination of unprotected benzo-fused heterocycles is reported, which allows for greater flexibility and efficiency in the modification of this important class of molecules. The gener...
Keywords: Aminations, Catalysis

Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases

We report our studies on the use of two catalyst systems, based on the ligands BrettPhos and RuPhos, which provide the widest scope for Pd-catalyzed C-N cross-coupling reactions to date. Often low ca...
Keywords: Arylations, Catalysis, Coupling reactions, Cross couplings, Ligands, Pharmaceutical

Stephen Buchwald Group – Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Stephen Buchwald Group – Professor Product Portal
Keywords: Aminations, Asymmetric catalysis, Asymmetric synthesis, Catalysis, Coupling reactions, Cross couplings, Fluorinations, Ligands, Solvents, transformation

Suzuki-Miyaura Cross-Coupling of Potassium Trifluoro(N-methylheteroaryl)borates with Aryl and Heteroaryl Halides

A new bulky biarylphosphine ligand (L8) has been developed that allows the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions than previously possible...
Keywords: Catalysis, Chromatography, Cross couplings, Flash chromatography, Ligands

Related Content

Buchwald Phosphine Ligands - For C-C, C-N, and C-O Bond Formation

For C-C, C-N, and C-O Bond Formation: Over the past several years, the Buchwald group has developed a series of bulky electron-rich phosphines that have garnered much attention for their ability to e...
Keywords: Aldrichimica Acta, Arylations, Catalysis, Chemfiles, Coupling reactions, Ligands, Methods, Type

Buchwald Precatalysts and Ligand Guide

Dialkylbiaryl phospine ligands, and the precatalysts derived from them, are commonly referred to as Buchwald Precatalysts and Ligands. These reagents have developed into a highly valuable class of co...
Keywords: Catalysis, Ligands

Peer-Reviewed Papers
15

References

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