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675512 Aldrich

(R)-(–)-VAPOL hydrogenphosphate

Synonym: (R)-2,2′-Diphenyl-3,3′-biphenanthryl-4,4′-diyl phosphate, (R)-VAPOL phosphoric acid, 18-Hydroxy-8,9-diphenyl-diphenanthro[4,3-d:3′,4′-f][1,3,2]dioxaphosphepin-18-oxide

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Description

Application

Useful chiral Bronsted acid catalyst in the addition of sulfonamides to Boc-activated aryl imines.

Catalyst involved in:
• Desymmetrization of meso-aziridines
• Asymmetric aza-Darzens aziridine synthesis
• Enantioselective ring-opening of mono-and bicyclic N-acyl meso aziridines
• Condensation of aldehydes with amino benzenesulfonamides
• Pictet-Spengler reactions

Packaging

100 mg in poly bottle

500 mg in glass bottle

Protocols & Applications

Reductive Amination using BINOL-Derived Chiral Phosphoric Acids

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Chiral Phosphoric Acids

BINOL-derived phosphoric acids are capable of catalyzing a range of interesting processes of which nucleophilic addition reactions to imine substrates are particularly noteworthy. List and coworkers ...
Aldrich ChemFiles 2007, 7.9, 11.
Keywords: Addition reactions, Aminations, Asymmetric synthesis, Catalysis, Chemfiles, Diels-Alder reaction, Nucleophilic additions, Pictet-Spengler reaction, Reductions, Reductive aminations

Peer-Reviewed Papers
15

References

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