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  • 698407 - 1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate

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698407 Aldrich

1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate

Synonym: (S,S)-Et-DUPHOS-Rh

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Description

Packaging

50, 250 mg in glass insert

Legal Information

Sold in collaboration with Kanata Chemical Technologies Inc. for research purposes only. These compounds were made and sold under license from E.I. du Pont de Nemours and Company, which license does not include the right to use the compounds in producing products for sale in the pharmaceutical field.

Application

(S,S)-Et-DUPHOS-Rh may be used as an efficient catalyst in the synthesis of (S)-2-quinolylalanine via asymmetric hydrogenation.

DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

Catalyst involved in:
• Oxidation of the δ-position via ruthenium catalysis
• Stereoselective hydrogenation reactions of dehydroamino acid esters and macrocyclic peptideomimetics
• Synthesis of cyclopeptide alkaloid mucronine E, fluoro-containing amino acids, and labeled protease inhibitors

General description

1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate is an electron-rich C2 symmetric bis(phospholane) ligand for enantioselective catalytic reactions.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

DuPhos and BPE Phospholane Ligands and Complexes

In the early 1990s, Burk and coworkers developed new electron-rich C2 symmetric bis(phospholane) ligands. The modular nature of these ligands allowed for variation of both phosphane substituent and b...
William Sommer and Daniel Weibel
Aldrich ChemFiles 2008, 8.2, 34.
Keywords: Aminations, Applications, Asymmetric catalysis, Asymmetric synthesis, Building blocks, Catalysis, Chemfiles, Crotylborations, Hydrogenations, Ligands, Reductions, Reductive aminations

Peer-Reviewed Papers
15

References

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