763004 Aldrich

CPhos Pd G3


Synonym: CPhos-G3-Palladacycle, CPhos-Pd-G3, [(2-Dicyclohexylphosphino-2′,6′-bis(N,N-dimethylamino) -1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)] palladium(II) methanesulfonate

  • Empirical Formula (Hill Notation) C41H54N3O3PPdS

  • Molecular Weight 806.34

  • Popular Documents:  Specification Sheet (PDF)  




100, 500 mg in poly bottle

5 g in glass bottle

General description

CPhos Pd G3 is a modified G3 precatalyst (G3′). It has been synthesized by Buchwald and coworkers from second generation (G2) precatalyst by methylation of the amino group present on biphenyl backbone. It is a useful catalyst for various cross-coupling reactions. They are versatile catalysts. They have long life in solution and are readily soluble in various organic solvents. G3- precatalysts have been employed in various C-N bond forming reactions.1

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WGK Germany 
Protocols & Articles


Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides

The highly selective palladium-catalyzed Negishi coupling of secondary alkylzinc reagents with heteroaryl halides is described. The development of atseries of biarylphosphine ligands has led to the i...
Keywords: Catalysis, Eliminations, Gas chromatography, Ligands, Negishi Coupling, Nuclear magnetic resonance spectroscopy, Oxidative additions, Reductive eliminations

Stephen Buchwald Group – Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Stephen Buchwald Group – Professor Product Portal
Keywords: Aminations, Asymmetric catalysis, Asymmetric synthesis, Catalysis, Coupling reactions, Cross couplings, Fluorinations, Ligands, Solvents, transformation

Peer-Reviewed Papers


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1. 2-Aminobiphenyl Palladacycles: The “Most Powerful” Precatalysts in C-C and C-Heteroatom Cross-Couplings. Bruneau A, et al. ACS Catalysis 5(2), 1386-1396, (2015)

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