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767840 Aldrich

Zinc difluoromethanesulfinate

95%

Synonym: 1,1-difluoro-methanesulfinic acid zinc salt (2:1), Baran difluoromethylation reagent, Bis(((difluoromethyl)sulfinyl)oxy)zinc, DFMS

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Properties

Related Categories Baran Diversinates, C-H Activation, Catalysis and Inorganic Chemistry, Chemical Synthesis, Difluoromethylation,
InChI Key   UGEYAPVLXKEKMP-UHFFFAOYSA-L
assay   95%
storage temp.   2-8°C
suitable for   Fluorinations

Description

Linkage

Frequently Asked Questions are available for this Product.

Packaging

1, 10, 100 g in glass bottle

100 mg in glass bottle

Application

Zinc difluoromethanesulfinate (DFMS) is part of a zinc sulfinate toolbox developed by Phil Baran for the simple and rapid diversification of heterocycles.†

Practical and Innate Carbon-Hydrogen Functionalization of Heterocycles

DFMS is a new reagent for direct difluoromethylation of organic substrates via a radical process. This mild, operationally simple, chemoselective, and scalable difluoromethylation method is compatible with a range of nitrogen-containing heteroarene substrates of varying complexity as well as select classes of conjugated p−systems and thiols.†

A New Reagent for Direct Difluoromethylation

Learn More at the Professor and Product Portal of Professor Phil S. Baran.

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Baran Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Baran Group - Professor Product Portal
Keywords: Building blocks, Fluorinations, Oxidations, Pharmaceutical

Baran Reagents FAQs

What do the Baran reagents do? Allow the placement of alkyl groups onto molecules in drug discovery by replacing a C-H bond with the corresponding C-C bond (trifluoromethyl, difluoromethyl, isopropyl...
Keywords: Agrochemicals, Alkylations, Drug discovery, Fluorinations, Liquid chromatography mass spectrometry, Medicinal chemistry, Nuclear magnetic resonance spectroscopy, PAGE, Solvents

Diversinates™: Any-Stage Functionalization of (Hetero)aromatic Scaffolds

The synthesis of heteroaromatic and aromatic compounds is at the heart of the chemical industry. With the ever-growing demand of new chemical entities coupled to the dwindling resources and time cons...
Keywords: Alkylations, Catalysis, Chemical industry, Cross couplings, PAGE

Protocols

Late Stage Difluoromethylation - Baran's DFMS Reagent

From our library of Protocols, Sigma-Aldrich presents Late Stage Difluoromethylation - Baran's DFMS Reagent
Keywords: Chromatography, Nuclear magnetic resonance spectroscopy, Thin layer chromatography

Peer-Reviewed Papers
15

References

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