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861650 Aldrich

(+)-Biotin 4-nitrophenyl ester

98%

Synonym: 4-Nitrophenyl (+)-biotinate, d-Biotin p-nitrophenyl ester, BNP

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Properties

Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Complex Molecules
InChI Key   YUDNXDTXQPYKCA-YDHLFZDLSA-N
assay   98%
optical activity   [α]25/D +51°, c = 2 in DMF: AcOH (99:1)
mp   163-165 °C(lit.)
solubility   methanol: soluble25 mg/mL, clear, colorless to greenish-yellow

Description

Packaging

100 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

(+)-Biotin 4-nitrophenyl ester may be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies. It may also be used to prepare biotinylated quinazoline derivatives, which shows inhibitory activities against VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinase. (+)-Biotin 4-nitrophenyl ester undergoes hydrolysis in the presence of Na[17O]H to form [17O2]biotin, which can be used in solid-state 17O NMR spectroscopic experiments to analyze large protein-ligand complexes.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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