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91862 Aldrich

Trimethyl(trifluoromethyl)silane solution

~2.0 M in THF

Synonym: (Trifluoromethyl)trimethylsilane, Ruppert′s reagent, Ruppert-Prakash reagent, TFMTMS, Trifluoromethyltrimethylsilane

  • CAS Number 81290-20-2

  • Linear Formula (CH3)3SiCF3

  • Molecular Weight 142.19

  •  Beilstein Registry Number 4241868

  •  MDL number MFCD00145454

  •  PubChem Substance ID 57653455

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Fluorination Reagents, Other Synthetic Reagents for C-C Bond Formation, Synthetic Reagents,
InChI Key   MWKJTNBSKNUMFN-UHFFFAOYSA-N
concentration   ~2.0 M in THF
refractive index   n20/D 1.386
density   0.91 g/mL at 20 °C

Description

Packaging

10, 50 mL in glass bottle

Application

Reactant for:
• Silver-mediated C-H trifluoromethylation of arenes
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
• Palladium-catalyzed oxidative trifluoromethylation of indoles
• Preparation of 5-HT1A antagonists

• Used as difluorocarbene source

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
RIDADR 
UN 1993BE 3 / PGII
WGK Germany 
3
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C
Protocols & Articles
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