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|publication info||C. Willis, Oxford University Press, 1996, 96 pp., soft cover|
This practical book uses a wide range of examples in a versatile approach to the design of effective syntheses. Retrosynthetic analysis--a method of identifying simple starting materials for a synthesis--is introduced with emphasis on the importance of bond polarity and functional group interconversions. The next section discusses how an effective route to a target molecule containing more than one functional group can be followed, while later chapters review methods for the control of chemo-, regio-, and stereoselectivity, and include a discussion of protecting groups. Finally, four syntheses of pyrrolidine alkaloids are compared using previously described principles.
1. Introduction to synthesis
2. Retrosynthetic analysis I: The basic concepts
3. Retrosynthetic analysis II: Latent polarity and FGIs
4. Retrosynthetic analysis III: Strategy and planning in synthesis
5. Selectivity I: Chemoselectivity and protecting groups
6. Chemoselectivity II: Regioselectivity
7. Chemoselectivity III: Stereoselectivity
8. Selected organic synthesis
Appendix: Synthon table
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