Enantioselective Synthesis of β-Amino Acids
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ISBN-10 0471186279
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ISBN-13 978-047118627-4
Properties
| publication info | E. Juaristi, ed., John Wiley & Sons, Ltd, 1997, 491 pp., hard cover |
Description
General description
This book presents an overview of the importance of -amino acids in pharmaceutical sciences, and discusses the most important methods that have been developed for the preparation of enantiomerically pure compounds. Each method is described by the organic chemist who developed it, and so will be written with authoritative, first-hand knowledge. This is the first book to summarize new available methodologies for preparing -amino acids in optically pure form, a recent development in this field. It also provides methods for synthesizing optically pure precursors to pharmacologically active substances, including -lacatams.
Table of Contents
PARTIAL TABLE OF CONTENTS:
The Medicinal Chemistry of -Amino Acids: Paclitaxel as an Illustrative Example.
Biological Activity of -Amino Acids and -Lactams.
Selective Transformations of N,N-Dibenzyl Protected Asparagine and Aspartic Acid Derivatives.
Synthesis of Nonracemic -Amino Acids via Chiral Sulfinimines.
Enantioselective Synthesis of -Amino Acids via 6-Substituted Perhydropyrimidin-4-Ones.
Efficient Stereoselective Preparation of the Taxol Phenylisoserine Side Chain.
Chemoenzymatic Synthesis of the Side Chain of Taxol.
Index.
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