Betulin

Papers

Correlation of cytotoxic activity of betulinines and their hydroxy analogues. Jan Sarek et al Bioorg. Med. Chem. Lett. 15, 4196-200, (2005)

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Lupane triterpenoids from Maytenus species. Marvin J Núñez et al J. Nat. Prod. 68, 1018-21, (2005)

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Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. Liwei Fu et al J. Nat. Prod. 68, 198-206, (2005)

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Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. Sara Hoet et al J. Nat. Prod. 70, 1360-3, (2007)

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Triterpenoid pyrazines and benzopyrazines with cytotoxic activity. Milan Urban et al J. Nat. Prod. 70, 526-32, (2007)

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Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Xiaoan Wen et al J. Med. Chem. 51, 3540-54, (2008)

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Antiproliferative triterpenes from Melaleuca ericifolia. Fatma M Abdel Bar et al J. Nat. Prod. 71, 1787-90, (2008)

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alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus. Atta-ur-Rahman et al J. Nat. Prod. 71, 910-3, (2008)

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Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. Charles Gauthier et al Bioorg. Med. Chem. Lett. 19, 2310-4, (2009)

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Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. Malgorzata Drag-Zalesinska et al Bioorg. Med. Chem. Lett. 19, 4814-7, (2009)

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Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. Charles Gauthier et al Bioorg. Med. Chem. 17, 2002-8, (2009)

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Chemical Constituents of the Roots of Euphorbia micractina. Wendong Xu et al J. Nat. Prod. 72, 1620-6, (2009)

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Betulin-derived compounds as inhibitors of alphavirus replication. Leena Pohjala et al J. Nat. Prod. 72, 1917-26, (2009)

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Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins. Charles Gauthier et al J. Nat. Prod. 72, 72-81, (2009)

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Structure-Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes. Genet, C., et al J. Med. Chem. 53, 178-190, (2010)

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Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells. Cindy Horwedel et al J. Med. Chem. 53, 4842-8, (2010)

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Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. Pu Zhang et al Bioorg. Med. Chem. Lett. 21, 338-41, (2011)

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Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. Zhongjie Liang et al Eur. J. Med. Chem. 46, 2011-21, (2011)

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Merck 14,1189

Beil. 6,II,937

FT-IR 2 (3), 4220:C / FT-NMR 1 (3), 567:C / IR-Spectra (2), 1277:G / IR-Spectra (3), 1493:G / NMR-Reference 2 (2), 919:A / RegBook 1 (2), 2855:F / Structure Index 1, 457:A:5