|Related Categories||Asymmetric Synthesis, Bioactive Small Molecules, CI-CY, Cell Biology, Chemical Synthesis,|
|optical activity||[α]23/D −109.2°, c = 1.5 in ethanol|
|Gene Information||human ... CYP2D6(1565)|
10, 100 g in glass bottle
Certificate of Analysis
Certificate of Origin
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||63-22-43-48/22|
|Safety Statements (Europe)||36/37|
Cinchona alkaloids and their derivatives have proven to catalyze an astonishing array of enantioselective transformations, providing access to chiral products of high enantiopurity.1 The presence of ...
William Sommer and Daniel Weibel
Aldrich ChemFiles 2008, 8.2, 74.
Keywords: Addition reactions, Aminations, Antimicrobials, Asymmetric synthesis, Catalysis, Desymmetrizations, Dihydroxylations, Ligands, Reductive aminations
Asymmetric hydrogenation on chirally modified Pt: origin of hydrogen in the N-H-O interaction between cinchonidine and ketone. Maeda N, Hungerbühler K, and Baiker A J. Am. Chem. Soc. 133(49), 19567-9, (2011)
Tosyl esters of cinchonidine and cinchonine alkaloids: the structure-reactivity relationship in the hydrolysis to 9-epibases. Karczmarzyk Z, Lipińska TM, Wysocki W, et al. Acta Crystallogr. C, Cryst. Struct. Commun. 67(Pt 9), o346-9, (2011)
Cation-π and π-π stacking interactions allow selective inhibition of butyrylcholinesterase by modified quinine and cinchonidine alkaloids. Nawaz SA, Ayaz M, Brandt W, et al. Biochem. Biophys. Res. Commun. 404(4), 935-40, (2011)
A single amino acid substitution confers high cinchonidine oxidation activity comparable with that of rabbit to monkey aldehyde oxidase 1. Fukiya K, Itoh K, Yamaguchi S, et al. Drug Metab. Dispos. 38(2), 302-7, (2010)
Construction of expression system of rabbit aldehyde oxidase cDNA for the clarification of species differences. Liu P, Liang S, Wang BJ, et al. Eur. J. Drug Metab. Pharmacokinet. 34(3-4), 205-11, (2009)
Platinum nanoparticles: the crucial role of crystal face and colloid stabilizer in the diastereoselective hydrogenation of cinchonidine. Schmidt E, Kleist W, Krumeich F, et al. Chemistry 16(7), 2181-92, (2010)
Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase. Itoh K, Yamamura M, Muramatsu S, et al. Xenobiotica 35(6), 561-73, (2005)
Enantioselective tandem reaction of chromone-derived Morita-Baylis-Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones. Zhong NJ, Liu L, Wang D, et al. Chem. Commun. 49(35), 3697-9, (2013)
Aldrich MSDS 1, 474:A / Corp MSDS 1 (1), 887:B / RegBook 1 (2), 2623:B / Sigma FT-IR 1 (1), 582:A / Structure Index 1, 413:B:8
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