D119806 Aldrich

Maleic hydrazide

ReagentPlus®, 99%

Synonym: 1,2-Dihydro-3,6-pyridazinedione, 3,6-Dihydroxypyridazine, 3,6-Pyridazinediol

  • CAS Number 123-33-1

  • Empirical Formula (Hill Notation) C4H4N2O2

  • Molecular Weight 112.09

  •  Beilstein Registry Number 112223

  •  EC Number 204-619-9

  •  MDL number MFCD00006665

  •  PubChem Substance ID 24893373

  • Popular Documents:  FTNMR (PDF)  



Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Pyridazines
grade   ReagentPlus®
assay   99%
autoignition temp.   707 °F
mp   299-301 °C (dec.)(lit.)



100 g in poly bottle

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Safety Information

Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
Flash Point(F) 
572 °F
Flash Point(C) 
300 °C

Protocols & Articles

Peer-Reviewed Papers


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A review of environmental and health risks of maleic hydrazide. Ponnampalam R, Mondy NI, and Babish JG Regul Toxicol Pharmacol 3(1), 38-47, (1983)


Maleic hydrazide: sprout suppression of potatoes in the field. De Blauwer V, Demeulemeester K, Demeyere A, et al. Commun. Agric. Appl. Biol. Sci. 77(3), 343-51, (2012)


[Inhibitory effects of exogenous abscisic acid and maleic hydrazide on panicle sprouting in hybrid rice F1]. Wang X, Tao LX, Tan HJ, et al. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao 31(4), 396-402, (2005)


[A study on inhibitory effect of plant growth retardants on earlier bolting of Chinese Angelica]. Zhang E Zhongguo Zhong Yao Za Zhi 24(1), 18-20, 63, (1999)


Flow injection chemiluminescence sensor using molecularly imprinted polymers as recognition element for determination of maleic hydrazide. Fang Y, Yan S, Ning B, et al. Biosens. Bioelectron. 24(8), 2323-7, (2009)


Cytotoxicity and mode of action of maleic hydrazide in root tips of Allium cepa L. Marcano L, Carruyo I, Del Campo A, et al. Environ. Res. 94(2), 221-6, (2004)


Cytotoxic effects of maleic hydrazide. Swietlińska Z and Zuk J Mutat. Res. 55(1), 15-30, (1978)


Herbicide effects on freshwater benthic diatoms: induction of nucleus alterations and silica cell wall abnormalities. Debenest T, Silvestre J, Coste M, et al. Aquat. Toxicol. 88(1), 88-94, (2008)


Maleic hydrazide: should the Delaney amendment apply to its use? Haley TJ J. Toxicol. Environ. Health A 2(5), 1085-94, (1977)


Sensitivity of Bidens laevis L. to mutagenic compounds. Use of chromosomal aberrations as biomarkers of genotoxicity. Pérez DJ, Lukaszewicz G, Menone ML, et al. Environ. Pollut. 159(1), 281-6, (2011)


Differential genotoxicity of ethyl methanesulphonate, N-ethyl-N-nitrosourea and maleic hydrazide in tobacco seedlings based on data of the Comet assay and two recombination assays. Gichner T Mutat. Res. 538(1-2), 171-9, (2003)


Improvement of Vicia-micronucleus test for assessment of soil quality: a proposal for international standardization. Foltête AS, Dhyèvre A, Férard JF, et al. Chemosphere 85(10), 1624-9, (2011)


Carboxymethylcellulose improves the antimutagenic activity of sodium selenite against maleic hydrazide in Vicia faba seedlings. De Marco A, Owczarek M, Ferri T, et al. Environ. Res. 90(2), 152-6, (2002)


Maleic hydrazide residues in tobacco and their toxicological implications. Meyer SA, Sheets TJ, and Seltmann H Rev. Environ. Contam. Toxicol. 98, 43-60, (1987)


Transformed roots of Crepis capillaris--a [corrected] sensitive system for the evaluation of the clastogenicity of abiotic agents. Juchimiuk J and Maluszynska J Mutat. Res. 565(2), 129-38, (2005)


Anticlastogenic effect of Spirulina maxima extract on the micronuclei induced by maleic hydrazide in Tradescantia. Ruiz Flores LE, Madrigal-Bujaidar E, Salazar M, et al. Life Sci. 72(12), 1345-51, (2003)


Determination of maleic hydrazide residues in garlic bulbs by HPLC. Mamani Moreno C, Stadler T, da Silva AA, et al. Talanta 89, 369-76, (2012)


Salicylic acid triggers genotoxic adaptation to methyl mercuric chloride and ethyl methane sulfonate, but not to maleic hydrazide in root meristem cells of Allium cepa L. Patra J, Sahoo MK, and Panda BB Mutat. Res. 581(1-2), 173-80, (2005)


Determination of hydrazine in maleic hydrazide technical and pesticide formulations by gas chromatography: collaborative study. Riggs AS, Borth DM, Tutty DG, et al. J. AOAC Int. 91(1), 5-12, (2008)


FISH in analysis of gamma ray-induced micronuclei formation in barley. Juchimiuk-Kwasniewska J, Brodziak L, and Maluszynska J J. Appl. Genet. 52(1), 23-9, (2011)


Reduced clastogenic activity of maleic hydrazide in Vicia faba seedlings grown in a situation of overcrowding stress. De Marco A, Owczarek M, Raglione M, et al. Mutat. Res. 581(1-2), 133-9, (2005)


Multicolour FISH in an analysis of chromosome aberrations induced by N-nitroso-N-methylurea and maleic hydrazide in barley cells. Juchimiuk J, Hering B, and Maluszynska J J. Appl. Genet. 48(2), 99-106, (2007)


Spectroscopic and thermal studies of chromium(III), molybdenum(VI) and ruthenium(0) complexes of maleic hydrazide. Mohamed HA, Ali SA, and Ramadan RM Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 64(4), 913-7, (2006)


Liquid chromatographic determination of maleic hydrazide in technical and formulated products: collaborative study. Mertz JL, Lau DY, and Borth DM J. AOAC Int. 89(4), 929-36, (2006)


Glyphosate, alachor and maleic hydrazide have genotoxic effect on Trigonella foenum-graecum L. Siddiqui S, Meghvansi MK, and Khan SS Bull. Environ. Contam. Toxicol. 88(5), 659-65, (2012)


Genotoxicity of maleic hydrazide, acridine and DEHP in Allium cepa root cells performed by two different laboratories. Rank J, Lopez LC, Nielsen MH, et al. Hereditas 136(1), 13-8, (2002)


[Simple analysis of maleic hydrazide in agricultural products by HPLC]. Kobayashi M, Nagayama T, Takano I, et al. Shokuhin Eiseigaku Zasshi 43(6), 356-61, (2002)


Evaluation of genotoxic activity of maleic hydrazide, ethyl methane sulfonate, and N-nitroso diethylamine in Tradescantia. Alvarez-Moya C, Santerre-Lucas A, Zúñiga-González G, et al. Salud Publica. Mex. 43(6), 563-9, (2001)


The Fate of maleic hydrazide on tobacco during smoking. Zhang H, Tang G, Liu N, et al. ScientificWorldJournal 2012, 451471, (2012)


Merck 14,5705

Beil. 24,IV,1186

Corp MSDS 1 (1), 1281:C / FT-IR 1 (2), 806:B / FT-IR 2 (3), 3823:D / FT-NMR 1 (3), 357:B / IR-Spectra (2), 1177:B / IR-Spectra (3), 1351:F / NMR-Reference 2 (2), 685:D / RegBook 1 (2), 2561:J / Sax 6, 1061 / Sigma FT-IR 1 (2), 690:A / Structure Index 1, 404:C:8

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