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D161608 Aldrich

N,N-Dimethylhydrazine

98%

Synonym: 1,1-Dimethylhydrazine, asym-Dimethylhydrazine

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Properties

Related Categories Building Blocks, Chemical Synthesis, Hydrazines, Nitrogen Compounds, Organic Building Blocks More...
vapor density   1.94 (vs air)
vapor pressure   103 mmHg ( 20 °C)
assay   98%
autoignition temp.   478 °F
expl. lim.   95 %
refractive index   n20/D 1.4075(lit.)
bp   60-62 °C(lit.)
density   0.79 g/mL at 20 °C(lit.)
storage temp.   2-8°C

Description

Biochem/physiol Actions

Lung and colon tumor initiator in experimental animal model.1,2

Packaging

5, 100, 500 g in glass bottle

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Safety & Documentation

Safety Information

Signal word 
Danger
Precautionary statements 
RIDADR 
UN 1163 6.1/PG 1
WGK Germany 
3
RTECS 
MV2450000
Flash Point(F) 
15.8 °F
Flash Point(C) 
-9 °C

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

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Carcinogen Selector - Endocrine System - Liver Endocrine

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Carcinogen Selector - Reproductive System - Lung

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Peer-Reviewed Papers

References

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1. Synthetic and naturally occurring hydrazines as possible cancer causative agents. Toth, B. Cancer Res. 35, 3693, (1975)

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2. Inhibitory effect of natural coumarin compounds, esculetin and esculin, on oxidative DNA damage and formation of aberrant crypt foci and tumors induced by 1,2-dimethylhydrazine in rat colons. Kaneko, T.; Tahara, S.; Takabayashi, F. Biol. Pharm. Bull. 30(11), 2052, (2007)

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1,1-Dimethylhydrazine. Rep. Carcinog. 11, III107-8, (2004)

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[Effects of astragalosides on induction of colorectal aberrant crypt foci by dimethylhydrazine and metabolizing enzymes in liver microsomes in rats]. Xiang KM and Chen XD Nan Fang Yi Ke Da Xue Xue Bao 30(7), 1720-1, 1723, (2010)

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[Intoxication induced by unsymmetrical dimethylhydrazine: characteristics and mechanism of its acute and chronic injuries]. Yue MX, Peng RY, Wang ZG, et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16(12), 740-2, (2004)

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1,1-Dimethylhydrazine. Rep. Carcinog. 10, 107-8, (2002)

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[Asymmetrical dimethylhydrazine in the environment: problems of monitoring and ways of their solution]. Malysheva AG, Sotnikov EE, and Moskovkin AS Gig. Sanit. (5), 74-6, (2003)

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1,1-Dimethylhydrazine. IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3, 1425-36, (1999)

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Lack of predictivity of bone marrow micronucleus test versus testis micronucleus test: comparison with four carcinogens. Cliet I, Melcion C, and Cordier A Mutat. Res. 292(2), 105-11, (1993)

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The effect of apple feeding on markers of colon carcinogenesis. Poulsen M, Mortensen A, Binderup ML, et al. Nutr. Cancer 63(3), 402-9, (2011)

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Oxidation of 1,1-dimethylhydrazine (UDMH) in aqueous solution with air and hydrogen peroxide. Lunn G and Sansone EB Chemosphere 29(7), 1577-90, (1994)

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Micronucleus test and erythropoiesis: effect of cobalt on the induction of micronuclei by mutagens. Suzuki Y, Shimizu H, Nagae Y, et al. Environ. Mol. Mutagen. 22(2), 101-6, (1993)

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Ras signaling pathway in the chemopreventive action of different ratios of fish oil and corn oil in experimentally induced colon carcinogenesis. Kansal S, Negi AK, Bhatnagar A, et al. Nutr. Cancer 64(4), 559-68, (2012)

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Determination of hydrazine, monomethylhydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine by nonaqueous capillary electrophoresis with amperometric detection. Guo L, Matysik FM, Gläser P, et al. Electrophoresis 26(17), 3341-8, (2005)

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A preliminary assessment of the potential environmental and human health impact of unsymmetrical dimethylhydrazine as a result of space activities. Carlsen L, Kenesova OA, and Batyrbekova SE Chemosphere 67(6), 1108-16, (2007)

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Organ-specific genotoxicity of the potent rodent colon carcinogen 1,2-dimethylhydrazine and three hydrazine derivatives: difference between intraperitoneal and oral administration. Sasaki YF, Saga A, Akasaka M, et al. Mutat. Res. 415(1-2), 1-12, (1998)

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Effects of prostaglandin E2 on the micronucleus formation in mouse bone marrow cells by various mutagens. Suzuki Y, Shimizu H, Ishikawa T, et al. Mutat. Res. 311(2), 287-93, (1994)

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Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1-dimethylhydrazine, in a medium-term bioassay. Cabral R, Hakoi K, Hoshiya T, et al. Teratog. Carcinog. Mutagen. 15(6), 307-12, (1995)

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Action of 1,1-dimethylhydrazine on bacterial cells is determined by hydrogen peroxide. Zavilgelsky GB, Kotova VY, and Manukhov IV Mutat. Res. 634(1-2), 172-6, (2007)

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Tumor-promoting activities of hydroquinone and 1,1-dimethylhydrazine after initiation of newborn mice with 1-methyl-1-nitrosourea. Tamura T, Shibutani M, Toyoda K, et al. Cancer Lett. 143(1), 71-80, (1999)

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Effect of chronic dietary ethanol consumption on colonic cancer in rats induced by 1,1-dimethylhydrazine. Hayashi N, Tsutsumi M, Fukura M, et al. Alcohol. Clin. Exp. Res. 31(1 Suppl), S72-6, (2007)

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Transformation products of 1,1-dimethylhydrazine and their distribution in soils of fall places of rocket carriers in Central Kazakhstan. Kenessov B, Alimzhanova M, Sailaukhanuly Y, et al. Sci. Total Environ. 427-428, 78-85, (2012)

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Impact of probiotic supplementation on mortality of induced 1,2-dimethylhydrazine carcinogenesis in a mouse model. Liboredo JC, Anastácio LR, Mattos LV, et al. Nutrition 26(7-8), 779-83, (2010)

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Unsymmetrical DMH - an isomer of 1,2 DMH - is it potent to induce gastrointestinal carcinoma in rats? Christudoss P, Selvakumar R, Pulimood AB, et al. Exp. Toxicol. Pathol. 59(6), 373-5, (2008)

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Lack of tumorigenic activity of 1,1-dimethylhydrazine in Syrian golden hamsters treated by subcutaneous injection. Jeong JY and Kamino K Exp. Toxicol. Pathol. 45(1), 61-3, (1993)

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Analysis of cigarette mainstream smoke for 1,1-dimethylhydrazine and vinyl acetate by gas chromatography-mass spectrometry. Diekmann J, Biefel C, and Rustemeier K J. Chromatogr. Sci. 40(9), 509-14, (2002)

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Development of a biosensor test system with GFP reporter protein for detection of DNA damages. Lavrinenko IA, Lavrinenko VA, Ryabchenko AV, et al. Bull. Exp. Biol. Med. 141(1), 33-5, (2006)

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Merck 14,3247

Beil. 4,IV,3322

Fieser 1,289 / Fieser 2,154 / Fieser 3,117 / Fieser 5,254 / Fieser 6,223 / Fieser 7,126 / Fieser 8,192 / Fieser 9,184 / Fieser 12,205 / Fieser 14,149 / Fieser 16,145

Aldrich MSDS 1, 777:D / Corp MSDS 1 (1), 1384:D / FT-IR 2 (1), 460:B / FT-IR 1 (1), 295:A / FT-NMR 1 (1), 471:A / IR-Spectra (3), 173:C / IR-Spectra (2), 156:B / NMR-Reference 2 (1), 253:C / RegBook 1 (1), 313:F / Sax 6, 1166 / Structure Index 1, 43:B:1 / Vapor Phase 3, 378:D

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