D28000 Aldrich



Synonym: N-Methyl-N-(p-tolylsulfonyl)nitrosamide, N-Methyl-N-nitroso-p-toluenesulfonamide, N-Nitroso-N-methyl-p-toluenesulfonamide, N-Nitroso-p-toluenesulfomethylamide, p-Tolylsulfomethylnitrosamide, Diazomethane precursor



Frequently Asked Questions

Frequently Asked Questions are available for this Product.


Nitrosylating agent for transition metal complexes, amines, and carbanions, as well as a precursor to diazomethane.

Diazald: The Preferred Method For Diazomethane Generation


25 g in poly bottle

Legal Information

Diazald is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Laboratory Gloves

Cross-Coupling Guide
Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
UN3234 - UN3224 DOT class 4.1 (N-Methyl-N-nitroso-p-methylbenzenesulfonamide) Self-reactive solid type C, temperature controlled)
WGK Germany 

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option:
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What solvents can be used to dissolve Product D28000, Diazald®?
According to the 13th edition of the Merck Index, it is soluble in ether, petroleum ether, benzene, chloroform, carbon tetrachloride. It is also soluble in ethanol.
Is there a protocol using Product D28000, Diazald®, to generate diazomethane?
For a general diazomethane generation protocol, please check out the Aldrich technical bulletin, AL-180 from the following link:
Is Diazald, Product No. D28000 product light-, moisture-, or heat-sensitive?
Per the MSDS, this product is light- and heat-sensitive. It may decompose and ignite when stored at a temperature above 40oC.
Can Product D28000, Diazald®, be used in mutagenesis studies?
Product D28000 (Diazald®) is the suggested alternative for MNNG (1-methyl-3-nitroso-1-nitroguanidine), which has been used for mutagenesis experiments. Unfortunately, Sigma-Aldrich has not tested the affect of Diazald® as a mutagenic agent. It is structurally distinct from MNNG. Products N4766 and N1517 (N-nitroso-N-methylurea), which are recommended for work in mutagenesis, might be more suitable alternatives than product D28000.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
Show more questions
Protocols & Articles

Related Content

Diazald in Chemical Synthesis

Diazomethane is an extremely versatile reagent for the preparation of both carbon-carbon and carbon-heteroatom bonds.1 It is one of the most common methylating reagents for the preparation of methyl ...
Keywords: Aldrichimica Acta, Alkylations, Carcinogens, Catalysis, Cyclopropanations, Mutagens, Ring expansion

Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

Z203076 Macro Diazald® kits, Joint: ST/NS 29/32 Clear-Seal joints
Z108510 Macro Diazald® kits, Joint: ST/NS 24/40 Clear-Seal joints
Z419761 Diazald® set with System 45 compatible connections, Glassware set, complete
Z411736 Aldrich® diazomethane-generator with System 45 compatible connection, for the preparation of diazomethane without ether
Z547867 Inner tube for System 45 MNNG diazomethane generator, pkg of 1 ea
Z100250 Diazald® kit with Clear-Seal® joints, Joint: ST/NS 19/22

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?