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D7927 Aldrich

Sinapic acid

≥98%, powder

Synonym: 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid, Sinapinic acid

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Properties

Related Categories Allium cepa (Onion), Allium sativum (Garlic), Armoracia rusticana (Horseradish), Berberis sp., Building Blocks,
assay   ≥98%
form   powder
mol wt   monoisotopic mol wt 224.06839 Da
mp   ~202 °C
solubility   H2O: slightly soluble (lit.)(lit.)
  methanol: water: soluble (lit.)(lit.)
  polar organic solvents: soluble (lit.)(lit.)

Description

Packaging

1, 5 g in poly bottle

Price and Availability

Suggested Laboratory Gloves


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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Matrix-assisted laser-desorption mass spectrometry using 355 nm radiation. Beavis R.C., Chait B.T. Rapid Commun. Mass Spectrom. 3, 432-435, (1989)

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Benzoylation and sinapoylation of glucosinolate R-groups in Arabidopsis. Lee S, Kaminaga Y, Cooper B, et al. Plant J. 72(3), 411-22, (2012)

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Expansion cooling in the matrix plume is under-recognized in MALDI mass spectrometry. Bae YJ, Moon JH, and Kim MS J. Am. Soc. Mass Spectrom. 22(6), 1070-8, (2011)

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Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats. Roy SJ and Mainzen Prince PS Eur. J. Pharmacol. 699(1-3), 213-8, (2013)

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[Changes in phenolic acids during maturation and lignification of Scots pine xylem]. Antonova GF, Varaksina TN, Zheleznichenko TV, et al. Ontogenez 43(4), 250-60, (2012)

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Protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats. Roy SJ and Stanely Mainzen Prince P Food Chem. Toxicol. 50(11), 3984-9, (2012)

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Elucidating the role of metals in Alzheimer's disease through the use of Surface-Enhanced Laser Desorption/Ionisation time-of-flight mass spectrometry. Watt AD, Perez KA, and Hung LW Methods Mol. Biol. 752, 229-40, (2011)

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1064 nm dispersive multichannel Raman spectroscopy for the analysis of plant lignin. Meyer MW, Lupoi JS, and Smith EA Anal. Chim. Acta 706(1), 164-70, (2011)

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UVR8 mediates UV-B-induced Arabidopsis defense responses against Botrytis cinerea by controlling sinapate accumulation. Demkura PV and Ballaré CL Mol. Plant 5(3), 642-52, (2012)

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Synthesis and application of ionic liquid matrices (ILMs) for effective pathogenic bacteria analysis in matrix assisted laser desorption/ionization (MALDI-MS). Abdelhamid HN, Gopal J, and Wu HF Anal. Chim. Acta 767, 104-11, (2013)

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Comparison of phenolic acids profile and antioxidant potential of six varieties of spelt (Triticum spelta L.). Gawlik-Dziki U, Świeca M, and Dziki D J. Agric. Food Chem. 60(18), 4603-12, (2012)

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Mechanism and kinetics studies on the antioxidant activity of sinapinic acid. Galano A, Francisco-Márquez M, and Alvarez-Idaboy JR Phys. Chem. Chem. Phys. 13(23), 11199-205, (2011)

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A newly synthesized sinapic acid derivative inhibits endothelial activation in vitro and in vivo. Zeng X, Zheng J, Fu C, et al. Mol. Pharmacol. 83(5), 1099-108, (2013)

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Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates. Jose C J M D S Menezes et al Eur. J. Med. Chem. 46, 773-7, (2011)

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Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Nelson KJ Anal. Biochem. 375(2), 187-95, (2008)

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Prediction model based on decision tree analysis for laccase mediators. Medina F, Aguila S, Baratto MC, et al. Enzyme Microb. Technol. 52(1), 68-76, (2013)

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New insights into the antioxidant activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives. Alexandra Gaspar et al Eur. J. Med. Chem. 44, 2092-9, (2009)

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Analysis of initial reactions of MALDI based on chemical properties of matrixes and excitation condition. Lai YH, Wang CC, Chen CW, et al. J. Phys. Chem. B 116(32), 9635-43, (2012)

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Interaction and solubilization of some phenolic antioxidants in Pluronic® micelles. Parmar A, Singh K, Bahadur A, et al. Colloids Surf. B Biointerfaces 86(2), 319-26, (2011)

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Fast quantitative determination of melamine and its derivatives by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Arnold A, Arrey TN, Karas M, et al. Rapid Commun. Mass Spectrom. 25(19), 2844-50, (2011)

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Neuroprotective effect of sinapic acid in a mouse model of amyloid β(1-42) protein-induced Alzheimer's disease. Lee HE, Kim DH, Park SJ, et al. Pharmacol. Biochem. Behav. 103(2), 260-6, (2012)

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Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages. Hisashi Matsuda et al Bioorg. Med. Chem. Lett. 15, 1949-53, (2005)

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Possible evidence of amide bond formation between sinapinic acid and lysine-containing bacterial proteins by matrix-assisted laser desorption/ionization (MALDI) at 355 nm. Fagerquist CK, Sultan O, and Carter MQ J. Am. Soc. Mass Spectrom. 23(12), 2102-14, (2012)

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N-Caffeoyl serotonin as selective COX-2 inhibitor. Takahashi T and Miyazawa M Bioorg. Med. Chem. Lett. 22(7), 2494-6, (2012)

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Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities. Maya Spasova et al Bioorg. Med. Chem. 16, 7457-61, (2008)

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Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition. Toshiyuki Takahashi et al Bioorg. Med. Chem. Lett. 21, 1983-6, (2011)

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Phenolic glycosides from berries of Pimenta dioica. Hiroe Kikuzaki et al J. Nat. Prod. 71, 861-5, (2008)

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The protein profile of Theobroma cacao L. seeds as obtained by matrix-assisted laser desorption/ionization mass spectrometry. Bertazzo A, Agnolin F, Comai S, et al. Rapid Commun. Mass Spectrom. 25(14), 2035-42, (2011)

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Separation, identification, and quantitation of phenolic acids in Chinese waxberry (Myrica Rubra) juice by HPLC-PDA-ESI-MS. Wang C, Zhao J, Chen F, et al. J. Food Sci. 77(2), C272-7, (2012)

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Protective role of sinapic acid against arsenic: induced toxicity in rats. Pari L and Mohamed Jalaludeen A Chem. Biol. Interact. 194(1), 40-7, (2011)

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Phytosteryl sinapates and vanillates: chemoenzymatic synthesis and antioxidant capacity assessment. Tan Z and Shahidi F Food Chem. 138(2-3), 1438-47, (2013)

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Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides. Tae-Souk Kang et al Bioorg. Med. Chem. Lett. 18, 1663-7, (2008)

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Determination of low-molecular mass phenols in red wines: the influence of chips, staves and micro-oxygenation aging tank. Gallego L, Nevares I, Fernández JA, et al. Food Sci. Technol. Int. 17(5), 429-38, (2011)

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Nitrate reductase- and nitric oxide-dependent activation of sinapoylglucose:malate sinapoyltransferase in leaves of Arabidopsis thaliana. Santos-Filho PR, Vitor SC, Frungillo L, et al. Plant Cell Physiol. 53(9), 1607-16, (2012)

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A thiophene-containing compound as a matrix for matrix-assisted laser desorption/ ionization mass spectrometry and the electrical conductivity of matrix crystals. Yasuda A, Ishimaru T, Nishihara S, et al. Eur. J. Mass Spectrom. (Chichester, Eng.) 19(1), 29-37, (2013)

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Phenolic composition and antioxidant effect of aqueous extract of Arisaema cum Bile, the Oriental Herb Medicine, in human fibroblast cells. Ahn CB, Shin TS, Seo HK, et al. Immunopharmacol. Immunotoxicol. 34(4), 661-6, (2012)

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Beil. 10,IV,2104

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