Flavone

Papers

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. Roger J Griffin et al J. Med. Chem. 48, 569-85, (2005)

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Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. Deniz Tasdemir et al J. Med. Chem. 49, 3345-53, (2006)

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Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. Mauricio Cabrera et al Bioorg. Med. Chem. 15, 3356-67, (2007)

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Toward prediction of alkane/water partition coefficients. Anita Toulmin et al J. Med. Chem. 51, 3720-30, (2008)

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Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. Daniela Schuster et al J. Med. Chem. 51, 4188-99, (2008)

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QSAR modeling of the interaction of flavonoids with GABA(A) receptor. Pablo R Duchowicz et al Eur. J. Med. Chem. 43, 1593-602, (2008)

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Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Yosuke Nishizaki et al Bioorg. Med. Chem. Lett. 19, 4706-10, (2009)

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Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Carolyn K Dong et al Bioorg. Med. Chem. Lett. 19, 972-5, (2009)

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Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Yagmur Muftuoglu et al Bioorg. Med. Chem. Lett. 20, 3050-64, (2010)

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A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Franco Chimenti et al Bioorg. Med. Chem. 18, 1273-9, (2010)

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Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. Mauricio Cabrera et al Bioorg. Med. Chem. 18, 5391-9, (2010)

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A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. Mariana Torres-Piedra et al Eur. J. Med. Chem. 45, 2606-12, (2010)

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Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. Guzmán Alvarez et al Eur. J. Med. Chem. 45, 5767-72, (2010)

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Relationship between the structures of flavonoids and their NF-?B-dependent transcriptional activities. Soon Young Shin et al Bioorg. Med. Chem. Lett. 21, 6036-41, (2011)

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Non-covalent inhibitors of rhinovirus 3C protease. Andrew Baxter et al Bioorg. Med. Chem. Lett. 21, 777-80, (2011)

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Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). Anne Pick et al Bioorg. Med. Chem. 19, 2090-102, (2011)

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Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. Hisashi Matsuda et al Bioorg. Med. Chem. 19, 2835-41, (2011)

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Synthesis and antifungal activities of natural and synthetic biflavonoids. Gabriel Sagrera et al Bioorg. Med. Chem. 19, 3060-73, (2011)

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Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches. Mariana Torres-Piedra et al Bioorg. Med. Chem. 19, 542-6, (2011)

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Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. Gugan Kothandan et al Eur. J. Med. Chem. 46, 4078-88, (2011)

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2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: Vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition. Andrew J Tilley et al Bioorg. Med. Chem. 20, 2353-61, (2012)

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Antioxidant properties of 4-quinolones and structurally related flavones. Jane Greeff et al Bioorg. Med. Chem. 20, 809-18, (2012)

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Merck 14,4092

Beil. 17,V,10,552

FT-IR 1 (2), 95:A / FT-IR 2 (2), 2504:C / FT-NMR 1 (2), 916:C / IR-Spectra (2), 792:D / IR-Spectra (3), 905:F / NMR-Reference 2 (2), 97:D / RegBook 1 (2), 1695:L / Sigma FT-IR 1 (2), 561:D / Structure Index 1, 269:D:4