5-Fluoroindole 98% | Sigma-Aldrich

Properties

Related Categories	Building Blocks, C7 to C9, Chemical Synthesis, Fluorinated Building Blocks, Heterocyclic Building Blocks, Heterocyclic Fluorinated Building Blocks, Indoles, Other Fluorinated Heterocycles More...
assay	98%
mp	45-48 °C(lit.)

Description

Packaging

1 g in glass bottle

Application

• Reactant for preparation of 5-HT6 receptor ligands¹
• Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators²
• Reactant for preparation of antitumor agents³
• Reactant for preparation of antibacterial agents⁴
• Reactant for preparation of immunosuppressive agents⁵
• Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes⁶
• Reactant for preparation of Myeloperoxidase Inhibitors⁷
• Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors⁸

Price and Availability

Related Papers

1. Rigidized 1-aryl sulfonyl tryptamines: synthesis and pharmacological evaluation as 5-HT6 receptor ligands. Nirogi, R.; et al. Bioorg. Med. Chem. Lett. 21, 4577, (2011)

Documents

Certificate of Analysis

FT-IR Raman

FT-NMR

Safety Information

Symbol	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes (Europe)	Xi
Risk Statements (Europe)	36/37/38
Safety Statements (Europe)	26-36
WGK Germany	3
Flash Point(F)	230 °F
Flash Point(C)	110 °C

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Indoles

Sigma-Aldrich is proud to offer a new series of ChemFiles—called Privileged Structures, to our Drug Discovery and Organic Synthesis customers. Each piece will highlight a specific motif, selected app...
Chemfiles Volume 4 Article 8
Keywords: Building blocks, Cardiovascular, Diabetes, Diseases, Drug discovery, Medicinal chemistry, Organic synthesis, Respiratory

Papers

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1. Rigidized 1-aryl sulfonyl tryptamines: synthesis and pharmacological evaluation as 5-HT6 receptor ligands. Nirogi, R.; et al. Bioorg. Med. Chem. Lett. 21, 4577, (2011)

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2. Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. Dolusic, E.; et al. J. Med. Chem. 54, 5320, (2011)

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3. Synthesis and anti-tumor activity of 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives in vitro. Zhang, F.; et al. Eur. J. Med. Chem. 46, 3149, (2011)

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4. Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. Burchak, O. N.; et al. Bioorg. Med. Chem. 19, 3204, (2011)

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5. Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Ge, H. M.; et al. Chem. Commun. (Camb.) 47, 2321, (2011)

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6. Discovery of novel N-Î²-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes. Yao, C.-H.; et al. J. Med. Chem. 54, 166, (2011)

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7. Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors. Soubhye, J.; et al. J. Med. Chem. 53, 8747, (2010)

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8. Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors. King, H. D.; et al. J. Med. Chem. 53, 7564, (2010)

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Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. Douglas R Davies et al J. Med. Chem. 52, 4694-715, (2009)

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Beil. 20,V,7,31

FT-NMR 1 (3), 125:C / IR-Spectra (3), 1244:C / IR-Spectra (2), 1081:B / RegBook 1 (2), 2403:A / Sigma FT-IR 1 (2), 573:B / Structure Index 1, 381:A:4 / Vapor Phase 3, 1500:C