Synonym: 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid
|Related Categories||Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Complex Molecules|
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1 g in poly bottle
250 mg in poly bottle
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purum, ≥97.0% (T)
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18β-glycyrrhetinic acid delivered orally induces isolated lymphoid follicle maturation at the intestinal mucosa and attenuates rotavirus shedding. Hendricks JM, Hoffman C, Pascual DW, et al. PLoS ONE 7(11), e49491, (2012)
18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. Long DR, Mead J, Hendricks JM, et al. Antimicrob. Agents Chemother. 57(1), 241-7, (2013)
18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice. Kuang P, Zhao W, Su W, et al. Int. J. Cancer 132(8), 1831-41, (2013)
18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. Yang JC, Myung SC, Kim W, et al. Mol. Cell Biochem. 370(1-2), 209-19, (2012)
18α-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Β1/Smad signaling pathway in human and rat hepatic stellate cells. Zong L, Qu Y, Xu MY, et al. Int. J. Med. Sci. 9(5), 370-9, (2012)
Human endothelial progenitor cells induce extracellular signal-regulated kinase-dependent differentiation of mesenchymal stem cells into smooth muscle cells upon cocultivation. Goerke SM, Plaha J, Hager S, et al. Tissue Eng. Part A 18(23-24), 2395-405, (2012)
Chemopreventive potential of 18beta-glycyrrhetinic acid: an active constituent of liquorice, in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. Kowsalya R, Vishwanathan P, and Manoharan S Pak. J. Biol. Sci. 14(11), 619-26, (2011)
The blood-brain barrier permeability of 18β-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan. Tabuchi M, Imamura S, Kawakami Z, et al. Cell. Mol. Neurobiol. 32(7), 1139-46, (2012)
ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. Niger C, Buo AM, Hebert C, et al. Am. J. Physiol. Cell Physiol. 302(7), C1035-44, (2012)
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