• USA Home
  • H50004 - 4-Hydroxyphenylacetic acid

EMAIL THIS PAGE TO A FRIEND

H50004 Aldrich

4-Hydroxyphenylacetic acid

98%

Purchase

Description

Packaging

25, 100 g in poly bottle

5 g in glass bottle

Application

Reagent used in the acylation of phenols1 and amines.2

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


TruPAGE™ Pre-cast Polyacrylamide GelsTruPAGE Gels run true every time!

  • . 2-Year Shelf Life
  • . Superior Band Resolution
  • . Strong & Tear Resistant
  • . Higher Capacity Wells



Duolink Webinar

Additional Products to Explore

Customers Also Viewed

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
WGK Germany 
3
RTECS 
AI2680000

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. J. Chem. Soc. Perkin Trans. I, 3005, (1991)

2. Korean J. Med. Chem. 1, 2,36, (1991)

Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Hashimoto K, Fukushima T, Shimizu E, et al. Arch. Gen. Psychiatry 60(6), 572-6, (2003)

Loading...


Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds. Jenner AM, Rafter J, and Halliwell B Free Radic. Biol. Med. 38(6), 763-72, (2005)

Loading...


HMDB: a knowledgebase for the human metabolome. Wishart DS, Knox C, Guo AC, et al. Nucleic Acids Res. 37(Database issue), D603-10, (2009)

Loading...


Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. Olthof MR, Hollman PC, Buijsman MN, et al. J. Nutr. 133(6), 1806-14, (2003)

Loading...


Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid. Botez MI and Young SN Brain 114 ( Pt 1A), 333-48, (1991)

Loading...


Bioavailability and catabolism of green tea flavan-3-ols in humans. Del Rio D, Calani L, Cordero C, et al. Nutrition 26(11-12), 1110-6, (2010)

Loading...


A metabolite profiling approach to identify biomarkers of flavonoid intake in humans. Loke, W.M., et al. J. Nucl. Med. 139, 2309-14, (2009)

Loading...


Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment. Alfredsson G and Wiesel FA Psychopharmacology 99(3), 322-7, (1989)

Loading...


Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Guneral F and Bachmann C Clin. Chem. 40(6), 862-6, (1994)

Loading...


Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment. Härnryd C, Bjerkenstedt L, Grimm VE, et al. Psychopharmacology 64(2), 131-4, (1979)

Loading...


Precursors and metabolites of phenylethylamine, m and p-tyramine and tryptamine in human lumbar and cisternal cerebrospinal fluid. Young SN, Davis BA, and Gauthier S J. Neurol. Neurosurg. Psychiatr. 45(7), 633-9, (1982)

Loading...


Competing pathways in the photo-Favorskii rearrangement and release of esters: studies on fluorinated p-hydroxyphenacyl-caged GABA and glutamate phototriggers. Stensrud K, Noh J, Kandler K, et al. J. Org. Chem. 74(15), 5219-27, (2009)

Loading...


Urinary excretion of conjugated homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid by persons on their usual diet and patients with neuroblastoma. Muskiet FA and Groen A Clin. Chem. 25(7), 1281-4, (1979)

Loading...


Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach. Stretch C, Eastman T, Mandal R, et al. J. Nutr. 142(1), 14-21, (2012)

Loading...


The effect of vigabatrin (gamma-vinyl GABA) on cerebral blood flow and metabolism. Spanaki MV, Siegel H, Kopylev L, et al. Neurology 53(7), 1518-22, (1999)

Loading...


gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. Do KQ, Lauer CJ, Schreiber W, et al. J. Neurochem. 65(6), 2652-62, (1995)

Loading...


SPE-NMR metabolite sub-profiling of urine. Jacobs DM, Spiesser L, Garnier M, et al. Anal. Bioanal. Chem 404(8), 2349-61, (2012)

Loading...


High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients. Heresco-Levy U, Bar G, Levin R, et al. Schizophr. Res. 91(1-3), 14-21, (2007)

Loading...


Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases. Rohan A Davis et al J. Med. Chem. 54, 1682-92, (2011)

Loading...


Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Roowi S, Mullen W, Edwards CA, et al. Mol. Nutr. Food. Res. 53 Suppl 1, S68-75, (2009)

Loading...


Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Sreekumar A, Poisson LM, Rajendiran TM, et al. Nature 457(7231), 910-4, (2009)

Loading...


[P-hydroxyphenylacetic acid concentrations in cerebrospinal fluid]. Kobayashi K, Koide Y, Yoshino K, et al. No. To Shinkei 34(8), 769-74, (1982)

Loading...


[Influence of bacteria of Bacillus genus on the causative agent of bacterial cancer of tomatoes]. Roĭ AA, Pasichnik LA, Tserkovniak LS, et al. Mikrobiol. Z. 74(5), 74-80, (2012)

Loading...


[Studies on the chemical constituents of extract with water from Forsythia suspensa]. Luan L, Wang GL, and Lin RC Zhong Yao Cai 33(2), 220-1, (2010)

Loading...


The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. van Dorsten FA, Grün CH, van Velzen EJ, et al. Mol. Nutr. Food. Res. 54(7), 897-908, (2010)

Loading...


GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. Zhang K and Zuo Y J. Agric. Food Chem. 52(2), 222-7, (2004)

Loading...


Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis. Hoffmann G, Aramaki S, Blum-Hoffmann E, et al. Clin. Chem. 35(4), 587-95, (1989)

Loading...


Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library. Rohan A Davis et al Bioorg. Med. Chem. 18, 14-8, (2010)

Loading...


Organic acids in the second morning urine in a healthy Swiss paediatric population. Boulat O, Gradwohl M, Matos V, et al. Clin. Chem. Lab Med. 41(12), 1642-58, (2003)

Loading...


Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis. Arns S, Gibe R, Moreau A, et al. Bioorg. Med. Chem. 20(6), 2131-40, (2012)

Loading...


Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC-MS, LC-MS and 1D NMR techniques. Farag MA, Porzel A, and Wessjohann LA Phytochemistry 76, 60-72, (2012)

Loading...


Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Gronwald W, Klein MS, Zeltner R, et al. Kidney Int. 79(11), 1244-53, (2011)

Loading...


Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin--are they prodrugs? Vissiennon C, Nieber K, Kelber O, et al. J. Nutr. Biochem. 23(7), 733-40, (2012)

Loading...


Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. Rating D, Siemes H, and Löscher W J. Neurol. 230(4), 217-25, (1983)

Loading...


Quercetin-dependent inhibition of nitration induced by peroxidase/H2O2/nitrite systems in human saliva and characterization of an oxidation product of quercetin formed during the inhibition. Hirota S, Takahama U, Ly TN, et al. J. Agric. Food Chem. 53(9), 3265-72, (2005)

Loading...


Reaction of peroxynitrite with Mn-superoxide dismutase. Role of the metal center in decomposition kinetics and nitration. Quijano C, Hernandez-Saavedra D, Castro L, et al. J. Biol. Chem. 276(15), 11631-8, (2001)

Loading...


Applications of p-hydroxyphenacyl (pHP) and coumarin-4-ylmethyl photoremovable protecting groups. Givens RS, Rubina M, and Wirz J Photochem. Photobiol. Sci. 11(3), 472-88, (2012)

Loading...


In the NadR regulon, adhesins and diverse meningococcal functions are regulated in response to signals in human saliva. Fagnocchi L, Pigozzi E, Scarlato V, et al. J. Bacteriol. 194(2), 460-74, (2012)

Loading...


Modeling the solubility of pharmaceuticals in pure solvents and solvent mixtures for drug process design. Ruether F and Sadowski G J. Pharm. Sci. 98(11), 4205-15, (2009)

Loading...


Enzyme-enhanced fluorescence detection of DNA on etched optical fibers. Niu SY, Li QY, Ren R, et al. Biosens. Bioelectron. 24(9), 2943-6, (2009)

Loading...


pH-dependent studies reveal an efficient hydroxylation mechanism of the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase. Ruangchan N, Tongsook C, Sucharitakul J, et al. J. Biol. Chem. 286(1), 223-33, (2011)

Loading...


Detection of propan-1,2-diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. Cady EB, Lorek A, Penrice J, et al. Magn. Reson. Med. 32(6), 764-7, (1994)

Loading...


Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. Shaywitz BA, Cohen DJ, and Bowers MB Neurology 25(1), 72-9, (1975)

Loading...


Plasma hormones and catecholamine metabolites in monozygotic twins discordant for psychosis. Walker EF, Bonsall R, and Walder DJ Neuropsychiatry. Neuropsychol. Behav. Neurol. 15(1), 10-7, (2002)

Loading...


Human salivary peroxidase-catalyzed oxidation of nitrite and nitration of salivary components 4-hydroxyphenylacetic acid and proteins. Takahama U, Hirota S, Nishioka T, et al. Arch. Oral Biol. 48(10), 679-90, (2003)

Loading...


Anti-hyperglycemic effect of Opuntia streptacantha Lem. Andrade-Cetto A and Wiedenfeld H J. Ethnopharmacol. 133(2), 940-3, (2011)

Loading...


The presence of 4-hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach. Takahama U, Oniki T, and Murata H FEBS Lett. 518(1-3), 116-8, (2002)

Loading...


Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. Czarnecka J, Cieślak M, and Michał K J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 822(1-2), 85-90, (2005)

Loading...


Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine. Mani AR, Pannala AS, Orie NN, et al. Biochem. J. 374(Pt 2), 521-7, (2003)

Loading...


Study on urinary metabolic profile of phenylketonuria by micellar electrokinetic capillary chromatography with dual electrochemical detection--potential clinical application in fast diagnosis of phenylketonuria. Zhang D, Li W, Zhang J, et al. Anal. Chim. Acta 694(1-2), 61-6, (2011)

Loading...


Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid. Brier S, Fagnocchi L, Donnarumma D, et al. Biochemistry 51(34), 6738-52, (2012)

Loading...


Urinary and plasma organic acids and amino acids in chronic fatigue syndrome. Jones MG, Cooper E, Amjad S, et al. Clin. Chim. Acta 361(1-2), 150-8, (2005)

Loading...


Inactivation of cystathionine beta-synthase with peroxynitrite. Celano L, Gil M, Carballal S, et al. Arch. Biochem. Biophys. 491(1-2), 96-105, (2009)

Loading...


Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy. Perosa SR, Porcionatto MA, Cukiert A, et al. Epilepsia 43 Suppl 5, 159-61, (2002)

Loading...


Metabolite profile of cerebrospinal fluid in patients with spina bifida: a proton magnetic resonance spectroscopy study. Pal K, Sharma U, Gupta DK, et al. Spine 30(3), E68-72, (2005)

Loading...


The transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms. Kemp LR, Dunstan MS, Fisher K, et al. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1616), 20120323, (2013)

Loading...


Label-free fluorescence method for screening G-quadruplex ligands. Fu L, Li B, and Zhang Y Anal. Biochem. 421(1), 198-202, (2012)

Loading...


Nitration of the salivary component 4-hydroxyphenylacetic acid in the human oral cavity: enhancement of nitration under acidic conditions. Takahama U, Imamura H, and Hirota S Eur. J. Oral Sci. 117(5), 555-62, (2009)

Loading...


Plasma and cerebrospinal fluid amino acids in epileptic patients. Rainesalo S, Keränen T, Palmio J, et al. Neurochem. Res. 29(1), 319-24, (2004)

Loading...


Excretion of amines and their metabolites by two patients in hepatic coma treated with L-dopa. Tyce GM, Stockard J, Sharpless NS, et al. Clin. Pharmacol. Ther. 34(3), 390-8, (1983)

Loading...


Determination of p-hydroxyphenylacetic acid in cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection. Kobayashi K, Koide Y, and Shohmori T Clin. Chim. Acta 123(1-2), 161-8, (1982)

Loading...


Hydroxytyrosol from tyrosol using hydroxyphenylacetic acid-induced bacterial cultures and evidence of the role of 4-HPA 3-hydroxylase. Liebgott PP, Amouric A, Comte A, et al. Res. Microbiol. 160(10), 757-66, (2009)

Loading...


Haemocytes play a commensal rôle in the synthesis of the dihydroxybenzoate required as a precursor for sclerotization of the egg case (ootheca) in the cockroach Periplaneta americana (L). Whitehead DL Bull. Entomol. Res. 101(3), 251-8, (2011)

Loading...


Urinary excretion of the nitrotyrosine metabolite 3-nitro-4-hydroxyphenylacetic acid in preterm and term infants. Hoehn T, Janssen S, Mani AR, et al. Neonatology 93(2), 73-6, (2008)

Loading...


Catecholamines and congenital pain insensitivity. Raw I, Schmidt BJ, and Merzel J Braz. J. Med. Biol. Res. 17(3-4), 271-9, (1984)

Loading...


Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism. Berrocal A, Navarrete J, Oviedo C, et al. J. Appl. Microbiol. 113(1), 126-34, (2012)

Loading...


Biocontrol ability of Lysobacter antibioticus HS124 against Phytophthora blight is mediated by the production of 4-hydroxyphenylacetic acid and several lytic enzymes. Ko HS, Jin RD, Krishnan HB, et al. Curr. Microbiol. 59(6), 608-15, (2009)

Loading...


Metabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats. Zhou L, Liu-Kreyche P, and Iyer RA Xenobiotica 41(4), 312-9, (2011)

Loading...


Nematicidal activities of 4-hydroxyphenylacetic acid and oidiolactone D produced by the fungus Oidiodendron sp. Ohtani K, Fujioka S, Kawano T, et al. Z. Naturforsch. C 66(1-2), 31-4, (2011)

Loading...


Kinetic cooperativity of tyrosinase. A general mechanism. Muñoz-Muñoz JL, Garcia-Molina F, Varon R, et al. Acta Biochim. Pol. 58(3), 303-11, (2011)

Loading...


Catecholamine metabolite excretion in spina bifida. McKibbin B, O'Gorman L, and Duckworth T J. Clin. Pathol. 22(6), 687-9, (1969)

Loading...


Photoremovable protecting groups: development and applications. Wirz J Photochem. Photobiol. Sci. 11(3), 445, (2012)

Loading...


Beil. 10,IV,543

Aldrich MSDS 1, 1074:B / Corp MSDS 1 (1), 1950:B / FT-IR 2 (2), 2609:C / FT-IR 1 (2), 161:C / FT-NMR 1 (2), 1018:C / IR-Spectra (3), 943:C / IR-Spectra (2), 826:B / NMR-Reference 2 (2), 158:B / RegBook 1 (2), 1757:N / Sigma FT-IR 1 (2), 641:A / Structure Index 1, 281:B:1

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?