2-Methylpiperidine 98% | Sigma-Aldrich

Properties

Related Categories	Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines More...
assay	98%
refractive index	n20/D 1.445(lit.)
bp	118-119 °C/753 mmHg(lit.)
density	0.844 g/mL at 25 °C(lit.)

Description

Packaging

100 mL in glass bottle

Application

Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation¹

Reactant for synthesis of:
• Azepan-4-ones via two step [5+2] annulation²
• 2-Aminobenzoxazoles³
• Unsymmetrically substituted ureas⁴
• Corticotropin-releasing factor receptor type 1 antagonists⁵
• Gefitinib analogues with anti-tumor activity⁶

Price and Availability

Related Papers

1. C-2 arylation of piperidines through directed transition-metal-catalyzed sp3 C-H activation. H. Prokopcova, et al., Chem. Eur. J. 16, 13063-13067, (2010)

Documents

Certificate of Analysis

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

Pressure-Temperature Nomograph

Safety Information

Symbol	GHS02, GHS05, GHS07
Signal word	Danger
Hazard statements	H225-H302-H315-H318-H335
Precautionary statements	P210-P261-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes (Europe)	F,Xn
Risk Statements (Europe)	11-22-37/38-41
Safety Statements (Europe)	16-26-39
RIDADR	UN 1993 3/PG 2
WGK Germany	3
RTECS	TN1240000
Flash Point(F)	50 °F
Flash Point(C)	10 °C

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

Set your institution to view full text papers.

1. C-2 arylation of piperidines through directed transition-metal-catalyzed sp3 C-H activation. H. Prokopcova, et al., Chem. Eur. J. 16, 13063-13067, (2010)

Loading...

2. Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation L. Cui, et al., Chem. Commun. (Camb.) 46, 3351-3353, (2010)

Loading...

3. Synthesis of 2-Aminobenzoxazoles Using Tetramethyl Orthocarbonate or 1,1-Dichlorodiphenoxymethane C. L. Cioffi, et al., J. Org. Chem. 75, 7942-7945, (2010)

Loading...

4. Acetoacetanilides as Masked Isocyanates: Facile and Efficient Synthesis of Unsymmetrically Substituted Ureas Y. Wei, et al., Org. Lett. 12, 4220-4223, (2010)

Loading...

5. Discovery of [(6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-yl)methyl]amines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists D. Zuev, et al., Bioorg. Med. Chem. Lett. 20, 3669-3674, (2010)

Loading...

6. Design and synthesis of novel Gefitinib analogues with improved anti-tumor activity X. Wu, et al., Bioorg. Med. Chem. 18, 3812-3822, (2010)

Loading...

Beil. 20,V,4,71

Aldrich MSDS 1, 1294:C / Corp MSDS 1 (2), 2418:D / FT-IR 1 (1), 359:D / FT-IR 2 (1), 560:D / FT-NMR 1 (1), 565:B / IR-Spectra (3), 211:E / IR-Spectra (2), 190:D / NMR-Reference 2 (1), 316:A / RegBook 1 (1), 381:L / Sax 6, 1914 / Sigma FT-IR 1 (2), 747:C / Structure Index 1, 54:C:5 / Vapor Phase 3, 450:B