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Tricyclic antidepressant; an active metabolite of clomipramine that preferentially blocks the norepinephrine transporter.
10, 25 mg in poly bottle
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Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration. Aitchison K, Datla K, Rooprai H, et al. J. Psychopharmacol. 24(8), 1261-8, (2010)
Pharmacokinetics of clomipramine and desmethylclomipramine after single-dose intravenous and oral administrations in cats. Lainesse C, Frank D, Meucci V, et al. J. Vet. Pharmacol. Ther. 29(4), 271-8, (2006)
Simultaneous analysis of clozapine, clomipramine and their metabolites by reversed-phase liquid chromatography. Palego L, Dell'Osso L, Marazziti D, et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 25(3), 519-33, (2001)
Delirious episodes induced by intravenous administration of clomipramine associated with an acute increase in its plasma concentrations. Ueda N, Yoshimura R, Eto S, et al. Psychiatry Clin. Neurosci. 54(6), 669-72, (2000)
Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine. Weigmann H, Härtter S, Bagli M, et al. Eur. Neuropsychopharmacol. 10(5), 401-5, (2000)
Simultaneous plasma level analysis of clomipramine, N-desmethylclomipramine, and fluvoxamine by reversed-phase liquid chromatography. Palego L, Marazziti D, Biondi L, et al. Ther. Drug Monit. 22(2), 190-4, (2000)
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection. de la Torre R, Ortuño J, Pascual JA, et al. Ther. Drug Monit. 20(3), 340-6, (1998)
Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation. Gex-Fabry M, Haffen E, Paintaud G, et al. Ther. Drug Monit. 22(6), 701-11, (2000)
The pharmacokinetics of clomipramine and desmethylclomipramine in dogs: parameter estimates following a single oral dose and 28 consecutive daily oral doses of clomipramine. Hewson CJ, Conlon PD, Luescher UA, et al. J. Vet. Pharmacol. Ther. 21(3), 214-22, (1998)
Application of HPLC with silica-phase and reversed-phase eluents for the determination of clomipramine and demethylated and 8-hydroxylated metabolites. Coudoré F, Hourcade F, Molinier-Manoukian C, et al. J. Anal. Toxicol. 20(2), 101-5, (1996)
Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data. Noguchi T, Shimoda K, and Takahashi S J. Affect. Disord. 29(4), 267-79, (1993)
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