P209 Aldrich

Parabanic acid


Synonym: Imidazolidinetrione, Oxalylurea, Trioxoimidazolidine



Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Imidazolines/Imidazolidines
assay   99%
mp   249 °C (dec.)(lit.)



5 g in glass bottle


Reactant for:
• Enantiospecific assembly of homochiral, hexanuclear palladium complexes1
• Mitsunobu reactions2
• Quantitative cascade condensation reactions3

Reactant for synthesis of:
• Pyridine derivatives4
• Nitroesters5
• Parabanic acid derivatives6

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GHS07  GHS07
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Protocols & Articles
Peer-Reviewed Papers


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1. Enantiospecific assembly of a homochiral, hexanuclear palladium complex H. M. Colquhoun, et al., Inorg. Chem. 8, 2009, (2009)

2. The Mitsunobu reaction D. L. Hughes, et al., Org. React. 42, (1992)

3. Quantitative cascade condensations between o-phenylenediamines and 1,2-dicarbonyl compounds without production of wastes G. Kaupp and M. R. Jamal, European J. Org. Chem. 8, 1368-1373, (2002)

4. An efficient synthesis of 3-amino-2-arylimidazo[1,2-a]pyridines M. Adib, et al., Tetrahedron Lett. 49, 5108-5110, (2008)

5. Synthesis of nitroesters based on methylol derivatives of parabanic and isocyanuric acids A. S. Ermakov, et al., Russ. J. Org. Chem. 41, 255-256, (2005)

6. [(η5-C5H5)Fe(CO)2](Fp)-complexes of the parabanic acid mono- and dianion: synthesis, X-ray structures and reactivity of the heterocyclic ligand K. Iski, et al., Polyhedron 23, 1441-1446, (2004)

Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products. Kaur H and Halliwell B Chem. Biol. Interact. 73(2-3), 235-47, (1990)


Thermal vibrations and electrostatic properties of parabanic acid at 123 and 298 K. He XM, Swaminathan S, Craven BM, et al. Acta Crystallogr. B 44 ( Pt 3), 271-81, (1988)


Parabanic acid for monitoring of oxygen radical activity in the injured human brain. Hillered L and Persson L Neuroreport 6(13), 1816-20, (1995)


Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds. Dávalos JZ, Ribeiro da Silva Md, Ribeiro da Silva MA, et al. J. Phys. Chem. A 114(34), 9237-45, (2010)


Highly selective aldose reductase inhibitors. II. Optimization of the aryl part of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids. Kotani T, Ishii A, Nagaki Y, et al. Chem. Pharm. Bull. 45(2), 297-304, (1997)


Reduction of oxalogenesis in a rapid gas chromatographic procedure for the analysis of oxalate ion in urine. Moye HA, Malagodi MH, and Clarke DH Clin. Chim. Acta 129(3), 385-90, (1983)


Suitability of reverse-phase columns from different sources for separation of uric acid from its oxidation products. Hicks M, Wong LS, and Day RO Anal. Biochem. 210(2), 428-30, (1993)


Merck 14,7022

Beil. 24,449

FT-IR 2 (1), 1373:B / IR-Spectra (2), 425:D / IR-Spectra (3), 480:D / Structure Index 1, 148:A:1

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