W222305 Aldrich


97%, FG

Synonym: 1,2,3-Tributyrylglycerol, Glycerol tributyrate, Glyceryl tributyrate, Tributyrin

  • CAS Number 60-01-5

  • Linear Formula (CH3CH2CH2COOCH2)2CHOCOCH2CH2CH3

  • Molecular Weight 302.36

  •  Beilstein Registry Number 1714746

  •  Council of Europe no. 747

  •  EC Number 200-451-5

  •  FEMA Number 2223

  •  Flavis number 9.211

  •  MDL number MFCD00009392

  •  PubChem Substance ID 24900938

  • Popular Documents:  FTNMR (PDF)  



Related Categories Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products, O - Z,
biological source   synthetic
grade   FG
reg. compliance   FDA 21 CFR (184.1903)
  EU Regulation 1334/2008 & 178/2002
assay   97%
refractive index   n20/D 1.435(lit.)
bp   129-131 °C/0.03 mmHg(lit.)
  287-288 °C(lit.)
density   1.032 g/mL at 20 °C(lit.)
Organoleptic   caramel; creamy; fatty
food allergen   no known allergens


Biochem/physiol Actions

Taste at 30 ppm


1 kg in poly bottle

5, 10 kg in poly drum

Other Notes

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Safety & Documentation

Safety Information

Personal Protective Equipment 
WGK Germany 
Flash Point(F) 
345.2 °F
Flash Point(C) 
174 °C

Protocols & Articles


Securing a Traceable Supply Chain for Food Grade Flavor Ingredients

Introduction Defining "Food Grade" Understanding "Food Grade" Versus "Industrial Grade" Top Questions to Ask a Flavor & Fragrances Supplier The Sigma-Aldrich Approach
Keywords: Food & Beverage, Food Safety, Solvents

Peer-Reviewed Papers


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Mosciano, G. Perfum. Flavor. 2nd ed., 24, 51, (1999)

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. Vinolo MA, Rodrigues HG, Hatanaka E, et al. J. Nutr. Biochem. 22(9), 849-55, (2011)


Oral administration of tributyrin increases concentration of butyrate in the portal vein and prevents lipopolysaccharide-induced liver injury in rats. Miyoshi M, Sakaki H, Usami M, et al. Clin. Nutr. 30(2), 252-8, (2011)


Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. Vinolo MA, Rodrigues HG, Festuccia WT, et al. Am. J. Physiol. Endocrinol. Metab. 303(2), E272-82, (2012)


Integration of chemical catalysis with extractive fermentation to produce fuels. Anbarasan P, Baer ZC, Sreekumar S, et al. Nature 491(7423), 235-9, (2012)


Gene cloning and characterization of a novel esterase from activated sludge metagenome. Zhang T and Han WJ Microb. Cell Fact. 8, 67, (2009)


Chemopreventive effects of the dietary histone deacetylase inhibitor tributyrin alone or in combination with vitamin A during the promotion phase of rat hepatocarcinogenesis. de Conti A, Kuroiwa-Trzmielina J, Horst MA, et al. J. Nutr. Biochem. 23(8), 860-6, (2012)


Anticarcinogenic actions of tributyrin, a butyric acid prodrug. Heidor R, Ortega JF, de Conti A, et al. Curr. Drug Targets 13(14), 1720-9, (2012)


Molecular cloning of a novel bioH gene from an environmental metagenome encoding a carboxylesterase with exceptional tolerance to organic solvents. Shi Y, Pan Y, Li B, et al. BMC Biotechnol. 13, 13, (2013)


High-throughput insertion mutagenesis and functional screening in the entomopathogenic fungus Beauveria bassiana. Fan Y, Zhang S, Kruer N, et al. J. Invertebr. Pathol. 106(2), 274-9, (2011)


Enzymatically catalyzed synthesis of low-calorie structured lipid in a solvent-free system: optimization by response surface methodology. Han L, Xu Z, Huang J, et al. J. Agric. Food Chem. 59(23), 12635-42, (2011)


Immunonutrition in patients undergoing major upper gastrointestinal surgery: a prospective double-blind randomised controlled study. Sodergren MH, Jethwa P, Kumar S, et al. Scand. J. Surg. 99(3), 153-61, (2010)


Carica papaya lipase: a naturally immobilized enzyme with interesting biochemical properties. Abdelkafi S, Barouh N, Fouquet B, et al. Plant Foods Hum. Nutr. 66(1), 34-40, (2011)


Outbreaks of keratoconjunctivitis in a camel herd caused by a specific biovar of Moraxella canis. Tejedor-Junco MT, Gutiérrez C, González M, et al. J. Clin. Microbiol. 48(2), 596-8, (2010)


Reduction in postlaminectomy epidural adhesions in sheep using a fibrin sealant-based medicated adhesion barrier. Richards PJ, Turner AS, Gisler SM, et al. J. Biomed. Mater. Res. B. Appl. Biomater. 92(2), 439-46, (2010)


Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid. Hou Y, Wang L, Yi D, et al. Br. J. Nutr. 111(10), 1748-58, (2014)


Transesterification of triglycerides using nitrogen-functionalized carbon nanotubes. Villa A, Tessonnier JP, Majoulet O, et al. ChemSusChem 3(2), 241-5, (2010)


Antioxidative and immunomodulatory effects of tributyrin supplementation on experimental colitis. Leonel AJ, Teixeira LG, Oliveira RP, et al. Br. J. Nutr. 109(8), 1396-407, (2013)


Dual function of tributyrin emulsion: solubilization and enhancement of anticancer effect of celecoxib. Kang SN, Hong SS, Lee MK, et al. Int. J. Pharm. 428(1-2), 76-81, (2012)


Spherezymes: a novel structured self-immobilisation enzyme technology. Brady D BMC Biotechnol. 8, 8, (2008)


Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. Guariento AH, Furtado KS, de Conti A, et al. Int. J. Cancer 135(1), 7-18, (2014)


The chemopreventive activity of the histone deacetylase inhibitor tributyrin in colon carcinogenesis involves the induction of apoptosis and reduction of DNA damage. Heidor R, Furtado KS, Ortega JF, et al. Toxicol. Appl. Pharmacol. 276(2), 129-35, (2014)


A new esterase, belonging to hormone-sensitive lipase family, cloned from Rheinheimera sp. isolated from industrial effluent. Virk AP, Sharma P, and Capalash N J. Microbiol. Biotechnol. 21(7), 667-74, (2011)


Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome. Rehni AK, Singh N, Rachamalla M, et al. Naunyn Schmiedebergs Arch. Pharmacol. 385(6), 605-19, (2012)


In vitro intestinal bioaccessibility of alkylglycerols versus triacylglycerols as vehicles of butyric acid. Martín D, Morán-Valero MI, Señoráns FJ, et al. Lipids 46(3), 277-85, (2011)


Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase. Xiao X, Ross LE, Sevilla WA, et al. Biochim. Biophys. Acta 1831(9), 1435-41, (2013)


Preparation and evaluation of tributyrin emulsion as a potent anti-cancer agent against melanoma. Kang SN, Lee E, Lee MK, et al. Drug Deliv. 18(2), 143-9, (2011)


Retinoic acid and tributyrin induce in-vitro radioiodine uptake and inhibition of cell proliferation in a poorly differentiated follicular thyroid carcinoma. Zhang M, Guo R, Xu H, et al. Nucl. Med. Commun. 32(7), 605-10, (2011)


Biochemical properties of pancreatic colipase from the common stingray Dasyatis pastinaca. Ben Bacha A, Karray A, Daoud L, et al. Lipids Health Dis. 10, 69, (2011)


Molecular modeling of lipase binding to a substrate-water interface. Gruber CC and Pleiss J Methods Mol. Biol. 861, 313-27, (2012)


Purification, biochemical and kinetic properties of recombinant Staphylococcus aureus lipase. Horchani H, Fendri A, Louati H, et al. Methods Mol. Biol. 861, 267-82, (2012)


High-throughput screening method for lipases/esterases. Mateos-Díaz E, Rodríguez JA, de Los Ángeles Camacho-Ruiz M, et al. Methods Mol. Biol. 861, 89-100, (2012)


Merck 14,9620

Beil. 2,IV,799

Arctander, 2973 / Corp MSDS 1 (2), 3401:B / FT-IR 2 (1), 993:D / FT-IR 1 (1), 620:D / FT-NMR 1 (1), 950:B / Fenaroli / IR-Spectra (2), 329:B / IR-Spectra (3), 370:B / NMR-Reference 2 (1), 525:B / RegBook 73 (1), 705:J / RegBook 1 (1), 705:J / Sax 6, 2616 / Structure Index 1, 107:B:5 / Vapor Phase 3, 647:D

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