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W236411 Aldrich

Decanoic acid

natural, ≥98%, FCC, FG

Synonym: 1-Nonanecarboxylic acid, Acid C10, C10:0, Capric acid, NSC 5025

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Properties

Related Categories A - D, A-D, Alphabetical Listings, C-D, Certified Food Grade Products,
biological source   from Cocos nucifera
grade   FG
  Halal
  Kosher
  natural
reg. compliance   FCC
  FDA 21 CFR (172.210)
  FDA 21 CFR (172.860)
  FDA 21 CFR (173.340)
  FDA 21 CFR (178.1010)
  EU Regulation 1334/2008 & 178/2002
vapor pressure   15 mmHg ( 160 °C)
assay   ≥98%
bp   268-270 °C(lit.)
mp   27-32 °C(lit.)
density   0.893 g/mL at 25 °C(lit.)
Organoleptic   fatty; citrus
food allergen   tree nuts

Description

Packaging

1 kg in glass bottle

5, 10 kg in poly drum

Other Notes

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Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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Decanoic acid

≥98%, FCC, FG

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analytical standard

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
WGK Germany 
1
RTECS 
HD9100000
Flash Point(F) 
230 °F
Flash Point(C) 
110 °C

Protocols & Articles

Articles

Securing a Traceable Supply Chain for Food Grade Flavor Ingredients

Introduction Defining "Food Grade" Understanding "Food Grade" Versus "Industrial Grade" Top Questions to Ask a Flavor & Fragrances Supplier The Sigma-Aldrich Approach
Keywords: Food & Beverage, Food Safety, Solvents

The Complex Regulatory Landscape for Natural Flavor Ingredients

Mr. Michael Sabisch, Senior Quality Assurance Specialist and Mr. David Smith, International Sales Coordinator, Sigma-Aldrich Flavors & Fragrances
Keywords: Fermentation, Food Safety, Oxidations

Understanding the Complexities of Kosher Ingredients

Dr. Luke Grocholl, Quality Assurance Supervisor, Sigma-Aldrich Flavors & Fragrances and Rabbi Gershon Segal
Keywords: Fermentation, Food & Beverage, Safety industry

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'Food Grade' in Flavors: Simple idea, complex environment [VIDEO]

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Keywords: Solvents

Flavor and Fragrance Natural Raw Materials: Definitions, Regulations and What to Look for [VIDEO]

What comes to mind when you see a food ingredient labeled ‘natural’? It seems like the simple answer would be that a natural ingredient comes from nature. However, with so many new technologies in pl...

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Octanoic acidemia and octanoylcarnitine excretion with dicarboxylic aciduria due to defective oxidation of medium-chain fatty acids. Duran M, Mitchell G, de Klerk JB, et al. J. Pediatr. 107(3), 397-404, (1985)

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Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestine. Ellis M, Chambers JD, Gwynne RM, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(8), G749-61, (2013)

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Chicken Ghrelin: Purification, cDNA Cloning, and Biological Activity. Hiroyuki Kaiya, Serge van der Geyten et al. Endocrinology 143, 3454-3463, (2002)

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Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis. Van Immerseel F, De Buck J, Boyen F, et al. Appl. Environ. Microbiol. 70(6), 3582-7, (2004)

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Sodium caprate transiently opens claudin-5-containing barriers at tight junctions of epithelial and endothelial cells. Del Vecchio G, Tscheik C, Tenz K, et al. Mol. Pharm. 9(9), 2523-33, (2012)

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The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate. O'Connor S, Szwej E, Nikodinovic-Runic J, et al. Biomaterials 34(11), 2710-8, (2013)

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The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto. Smallegange RC J. Chem. Ecol. 35(8), 933-43, (2009)

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SPE-NMR metabolite sub-profiling of urine. Jacobs DM, Spiesser L, Garnier M, et al. Anal. Bioanal. Chem 404(8), 2349-61, (2012)

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Ranking the toxicity of fatty acids on Jurkat and Raji cells by flow cytometric analysis. Lima TM, Kanunfre CC, Pompéia C, et al. Toxicol. In Vitro 16(6), 741-7, (2002)

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Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length. Wanten GJ, Janssen FP, and Naber AH Eur. J. Clin. Invest. 32(4), 285-9, (2002)

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Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. Krug SM, Amasheh M, Dittmann I, et al. Biomaterials 34, 275-282, (2013)

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Application of vesicular coacervate phase for microextraction based on solidification of floating drop. Moradi M and Yamini Y J. Chromatogr. A 1229, 30-7, (2012)

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Quantum dot targeting with lipoic acid ligase and HaloTag for single-molecule imaging on living cells. Liu DS, Phipps WS, Loh KH, et al. ACS Nano 6(12), 11080-7, (2012)

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Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis. Silva CL, Passos M, and Câmara JS Talanta 89, 360-8, (2012)

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Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus. Kaiya H, Kojima M, Hosoda H, et al. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 135(3), 421-9, (2003)

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Intestinal concentrations of free and encapsulated dietary medium-chain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets. Zentek J, Buchheit-Renko S, Männer K, et al. Arch. Anim. Nutr. 66(1), 14-26, (2012)

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Physiology and pathophysiology of organic acids in cerebrospinal fluid. Hoffmann GF, Meier-Augenstein W, Stöckler S, et al. J. Inherit. Metab. Dis. 16(4), 648-69, (1993)

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Improvement of intestinal absorption of forsythoside A in weeping forsythia extract by various absorption enhancers based on tight junctions. Zhou W, Qin KM, Shan JJ, et al. Phytomedicine 20(1), 47-58, (2012)

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An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Yunbao Liu et al J. Nat. Prod. 73, 1193-5, (2010)

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Gas-chromatographic estimation of urinary oxalate and its comparison with a colorimetric method. Farrington CJ and Chalmers AH Clin. Chem. 25(12), 1993-6, (1979)

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Membrane stress caused by octanoic acid in Saccharomyces cerevisiae. Liu P, Chernyshov A, Najdi T, et al. Appl. Microbiol. Biotechnol. 97(7), 3239-51, (2013)

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A role for tricellulin in the regulation of gill epithelium permeability. Kolosov D and Kelly SP Am. J. Physiol. Regul. Integr. Comp. Physiol. 304(12), R1139-48, (2013)

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Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Zhang M, Lv X, Li J, et al. Mol. Cell. Endocrinol. 363(1-2), 122-30, (2012)

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Development of a new and environment friendly hollow fiber-supported liquid phase microextraction using vesicular aggregate-based supramolecular solvent. Moradi M, Yamini Y, Rezaei F, et al. Analyst 137(15), 3549-57, (2012)

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Acute mechanism of medium chain fatty acid-induced enhancement of airway epithelial permeability. Coyne CB, Ribeiro CM, Boucher RC, et al. J. Pharmacol. Exp. Ther. 305(2), 440-50, (2003)

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The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells. Hughes SD, Kanabus M, Anderson G, et al. J. Neurochem. 129(3), 426-33, (2014)

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Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon. Wallon C, Braaf Y, Wolving M, et al. Scand. J. Gastroenterol. 40(5), 586-95, (2005)

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Close-packed monolayers of charged Janus-type nanoparticles at the air-water interface. Sashuk V, Hołyst R, Wojciechowski T, et al. J. Colloid. Interface Sci. 375(1), 180-6, (2012)

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An attempt to clarify the mechanism of the penetration enhancing effects of lipophilic vehicles with differential scanning calorimetry (DSC). Leopold CS and Lippold BC J. Pharm. Pharmacol. 47(4), 276-81, (1995)

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Effect of fatty acids on the β-oxidation system and thioesterase of Lactococcus lactis subspecies lactis. Li L and Ma Y J. Dairy Sci. 96(4), 2003-10, (2013)

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Percolation analysis in electrical conductivity of Madin-Darby canine kidney and Caco-2 cells by permeation-enhancing agents. Washiyama M, Koizumi N, Fujii M, et al. Biol. Pharm. Bull. 36(3), 384-9, (2013)

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Comparing micellar, hemolytic, and antibacterial properties of di- and tricarboxyl dendritic amphiphiles. Bhadreshkumar B Maisuria et al Bioorg. Med. Chem. 19, 2918-26, (2011)

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Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. Ohdoi C, Nyhan WL, and Kuhara T J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 792(1), 123-30, (2003)

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Transcriptional analysis of the effect of exogenous decanoic acid stress on Streptomyces roseosporus. Liao G, Liu Q, and Xie J Microb. Cell Fact. 12, 19, (2013)

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Absorption-enhancing effect of glycyrrhizin induced in the presence of capric acid. Imai T, Sakai M, Ohtake H, et al. Int. J. Pharm. 294(1-2), 11-21, (2005)

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Reverse micelle-mediated dispersive liquid-liquid microextraction of 2,4-dichlorophenoxyacetic acid and 4-chloro-2-methylphenoxyacetic acid. Tayyebi M, Yamini Y, and Moradi M J. Sep. Sci. 35(18), 2491-8, (2012)

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Vesicular aggregate-based solventless microextraction of Ochratoxin A in dried vine fruits prior to liquid chromatography and fluorescence detection. Caballero-Casero N, García-Fonseca S, and Rubio S Talanta 89, 377-82, (2012)

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Safety of medium-chain triglycerides used as an intraocular tamponading agent in an experimental vitrectomy model rabbit. Auriol S, Mahieu L, Brousset P, et al. Retina (Philadelphia, Pa.) 33(1), 217-23, (2013)

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Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids. Tanaka S, Saitoh O, Tabata K, et al. J. Gastroenterol. Hepatol. 16(7), 748-54, (2001)

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Enhancement by sodium caprate and sodium deoxycholate of the gastrointestinal absorption of berberine chloride in rats. Fan D, Wu X, Dong W, et al. Drug Dev. Ind. Pharm. 39(9), 1447-56, (2013)

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Analysis of daidzein in nanoparticles after oral co-administration with sodium caprate to rats by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Ma Y, Zhang L, Zhao X, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 907, 21-6, (2012)

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Investigation of transport mechanism of exendin-4 across Madin Darby canine kidney cell monolayers. Wang M, Sun B, Feng J, et al. Biol. Pharm. Bull. 35(5), 745-52, (2012)

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Transport of a lipophilic ionizable permeant (capric acid) across a lipophilic membrane (silicone polymer membrane) from aqueous buffered solutions in the presence of hydroxypropyl-β-cyclodextrin. Hymas RV, Ho NF, and Higuchi WI J. Pharm. Sci. 101(7), 2340-52, (2012)

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Evaluation of percutaneous absorption of esculetin: effect of chemical enhancers. del Rio Sancho S, Serna Jiménez CE, Calatayud Pascual MA, et al. Planta Med. 79(2), 131-6, (2013)

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Stereoselective synthesis of fully protected (2S,4S,6S)-2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD). Zhang W, Li X, Ding N, et al. J. Pept. Sci. 18(3), 163-9, (2012)

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Synthesis of monocaprin catalyzed by lipase. Da Silva MA, Medeiros VC, Langone MA, et al. Appl. Biochem. Biotechnol. 105 -108, 757-67, (2003)

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Characterization of two long-chain fatty acid CoA ligases in the Gram-positive bacterium Geobacillus thermodenitrificans NG80-2. Dong Y, Du H, Gao C, et al. Microbiol. Res. 167(10), 602-7, (2012)

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Cloning, characterization, and expression analysis of acyl-acyl carrier protein (ACP)-thioesterase B from seeds of Chinese Spicehush (Lindera communis). Dong S, Huang J, Li Y, et al. Gene 542(1), 16-22, (2014)

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Intestinal absorption of raltitrexed and evaluation of the effects of absorption enhancers. Yu Y, Lu Y, Zhao X, et al. Pharmazie 68(9), 732-43, (2013)

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A comparison of the physicochemical properties and fatty acid composition of indaiá (Attalea dubia) and Babassu (Orbignya phalerata) oils. Ferreira BS, Faza LP, and Le Hyaric M ScientificWorldJournal 2012, 532374, (2012)

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Merck 14,1758

Beil. 2,IV,1041

Aldrich MSDS 1, 551:B / Arctander, 840 / Corp MSDS 1 (1), 1015:C / FT-IR 2 (1), 758:C / FT-IR 1 (1), 483:C / FT-NMR 1 (1), 754:B / IR-Spectra (3), 285:B / IR-Spectra (2), 257:B / NMR-Reference 2 (1), 421:B / RegBook 1 (1), 535:C / RegBook 40 (1), 535:C / Sax 6, 858 / Sigma FT-IR 1 (1), 1372:D / Structure Index 1, 75:A:5 / Vapor Phase 3, 575:D

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