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W294705 Aldrich

Propyl gallate

≥98%, FCC

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester

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Properties

Related Categories Alphabetical Listings, Flavors and Fragrances, Follows IFRA Guidelines, Halal Certified Products, Kosher Certified Products,
biological source   synthetic
grade   Halal
  Kosher
  follows IFRA guidelines
reg. compliance   EU Regulation 1223/2009
  FCC
  FDA 21 CFR (172.615)
  FDA 21 CFR (175.125)
  FDA 21 CFR (175.300)
  FDA 21 CFR (175.380)
  FDA 21 CFR (175.390)
  EU Regulation 1334/2008 & 178/2002
  EU Regulation 178/2002
assay   ≥98%
mp   146-149 °C(lit.)
GMO content   GMO-free
Organoleptic   odorless
food allergen   no known allergens
fragrance allergen   no known allergens

Description

Packaging

1 kg in poly bottle

10 kg in fiber drum

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Other Notes

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Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
2
RTECS 
LW8400000
Flash Point(F) 
368.6 °F
Flash Point(C) 
187 °C
Protocols & Articles

Articles

Understanding the Complexities of Kosher Ingredients

Dr. Luke Grocholl, Quality Assurance Supervisor, Sigma-Aldrich Flavors & Fragrances and Rabbi Gershon Segal
Keywords: Fermentation, Food & Beverage, Safety industry

Related Content

Flavors and Fragrances Quality and Regulatory

From a comprehensive vendor approval process, to the testing of raw material at receipt as well as when product is ready to be shipped; we prove our dedication to supply chain transparency, every day.
Keywords: Food Safety

Peer-Reviewed Papers
15

References

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