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W294705 Aldrich

Propyl gallate

≥98%, FCC

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester

Properties

Related Categories Alphabetical Listings, Bioactive Small Molecules, Cell Biology, Flavors and Fragrances, Halal Certified Products,
biological source   from synthetic
grade   Halal
  Kosher
reg. compliance   FCC
  FDA 21 CFR (172.615)
  FDA 21 CFR (175.125)
  FDA 21 CFR (175.300)
  FDA 21 CFR (175.380)
  FDA 21 CFR (175.390)
  EU Regulation 1334/2008 & 178/2002
  EU Regulation 178/2002
assay   ≥98%
mp   146-149 °C(lit.)
Organoleptic   odorless
allergen   no known allergens

Description

Packaging

1 kg in poly bottle

5 kg in poly drum

10 kg in fiber drum

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Other Notes

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