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W302503 Aldrich

Sodium benzoate

≥99%, FCC, FG

Synonym: Benzoic acid sodium salt

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Properties

Related Categories Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products,
biological source   synthetic
grade   FG
  Halal
  Kosher
  NI
reg. compliance   FCC
  FDA 21 CFR (150.141)
  FDA 21 CFR (150.161)
  FDA 21 CFR (166.110)
  FDA 21 CFR (181.23)
  EU Regulation 1333/2008 & 178/2002
  EU Regulation 178/2002
assay   ≥99%
mp   >300 °C(lit.)
Organoleptic   odorless
food allergen   no known allergens

Description

Packaging

1 kg in poly bottle

10 kg in fiber drum

Other Notes

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Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




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Sodium benzoate

puriss., meets analytical specification of Ph. Eur., BP, FCC, E211, 99.0-100.5% (calc. to the dried substance), powder

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ReagentPlus®, 99%

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
1
RTECS 
DH6650000
Flash Point(F) 
>212 °F
Flash Point(C) 
>100 °C

Protocols & Articles

Articles

Determination of Water Content in Sodium benzoate Using Karl Fischer Titration

Carboxylic acid salts can be straightforwardly analyzed provided the sample dissolves rapidly in the working medium. Dissolution is accelerated by the addition of formamide, titration at elevated tem...
Keywords: Titrations

Securing a Traceable Supply Chain for Food Grade Flavor Ingredients

Introduction Defining "Food Grade" Understanding "Food Grade" Versus "Industrial Grade" Top Questions to Ask a Flavor & Fragrances Supplier The Sigma-Aldrich Approach
Keywords: Food & Beverage, Food Safety, Solvents

Understanding the Complexities of Kosher Ingredients

Dr. Luke Grocholl, Quality Assurance Supervisor, Sigma-Aldrich Flavors & Fragrances and Rabbi Gershon Segal
Keywords: Fermentation, Food & Beverage, Safety industry

Peer-Reviewed Papers

References

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Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Alessio Innocenti et al Bioorg. Med. Chem. Lett. 15, 573-8, (2005)

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Cutaneous adverse reactions to amoxicillin-clavulanic acid suspension in children: the role of sodium benzoate. Mori F, Barni S, Pucci N, et al. Curr. Drug Saf. 7(2), 87-91, (2012)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates. Alessio Innocenti et al Bioorg. Med. Chem. 17, 2654-7, (2009)

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Total synthesis of (+)-grandifloracin by iron complexation of a microbial arene oxidation product. Palframan MJ, Kociok-Köhn G, and Lewis SE Org. Lett. 13(12), 3150-3, (2011)

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Spectroscopic studies on the interaction of sodium benzoate, a food preservative, with calf thymus DNA. Zhang G and Ma Y Food Chem. 141(1), 41-7, (2013)

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Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. Khasnavis S and Pahan K J. Neuroimmune Pharmacol. 7(2), 424-35, (2012)

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D-Serine regulates proliferation and neuronal differentiation of neural stem cells from postnatal mouse forebrain. Huang X, Kong H, Tang M, et al. CNS Neurosci. Ther. 18(1), 4-13, (2012)

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Carbonic anhydrase inhibitors. Inhibition of the ß-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives. Fabrizio Carta et al Bioorg. Med. Chem. Lett. 21, 2521-6, (2011)

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Argininosuccinate lyase deficiency. Nagamani SC, Erez A, and Lee B Genet. Med. 14(5), 501-7, (2012)

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Isolation and characterization of a lipopeptide bioemulsifier produced by Pseudomonas nitroreducens TSB.MJ10 isolated from a mangrove ecosystem. de Sousa T and Bhosle S Bioresour. Technol. 123, 256-62, (2012)

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Interaction of sodium benzoate with trypsin by spectroscopic techniques. Mu Y, Lin J, and Liu R Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1), 130-5, (2011)

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The effect of continuous exposure of copper on the properties and extracellular polymeric substances (EPS) of bulking activated sludge. Li J, Liu X, Liu Y, et al. Environ. Sci. Pollut. Res. Int. 18(9), 1567-73, (2011)

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Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro. Ciardi C, Jenny M, Tschoner A, et al. Br. J. Nutr. 107(6), 826-33, (2012)

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[Rationale for the use of sodium benzoate in clinical hepatology]. Poo JL, Cervera E, de Hoyos A, et al. Rev. Invest. Clin. 42 Suppl, 101-5, (1990)

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Effects of dietary benzoic acid and sodium-benzoate on performance, nitrogen and mineral balance and hippuric acid excretion of piglets. Gräber T, Kluge H, Hirche F, et al. Arch. Anim. Nutr. 66(3), 227-36, (2012)

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Sodium benzoate-rich beverage consumption is associated with increased reporting of ADHD symptoms in college students: a pilot investigation. Beezhold BL, Johnston CS, and Nochta KA J. Atten. Disord. 18(3), 236-41, (2014)

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Arginase deficiency with new phenotype and a novel mutation: contemporary summary. Tsang JP, Poon WL, Luk HM, et al. Pediatr. Neurol. 47(4), 263-9, (2012)

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Concentration and application order effects of sodium benzoate and eugenol mixtures on the growth inhibition of Saccharomyces cerevisiae and Zygosaccharomyces bailii. Dai Y, McLandsborough LA, Weiss J, et al. J. Food Sci. 75(7), M482-8, (2010)

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Application of polylactic acid coating with antimicrobials in reduction of Escherichia coli O157:H7 and Salmonella Stanley on apples. Jin T and Niemira BA J. Food Sci. 76(3), M184-8, (2011)

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Effect of preservatives on Shiga toxigenic phages and Shiga toxin of Escherichia coli O157:H7. Subils T, Aquili V, Ebner G, et al. J. Food Prot. 75(5), 959-65, (2012)

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Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor. Lane HY, Lin CH, Green MF, et al. JAMA Psychiatry 70(12), 1267-75, (2013)

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Hyperammonemia in a patient with late-onset ornithine carbamoyltransferase deficiency. Choi DE, Lee KW, Shin YT, et al. J. Korean Med. Sci. 27(5), 556-9, (2012)

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Shelf life extension of sugarcane juice using preservatives and gamma radiation processing. Mishra BB, Gautam S, and Sharma A J. Food Sci. 76(8), M573-8, (2011)

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Methylmalonic acidemia and hyperglycemia: an unusual association. Imen M, Hanene B, Ichraf K, et al. Brain Dev. 34(2), 113-4, (2012)

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Application of hydrotropy to transdermal formulations: hydrotropic solubilization of polyol fatty acid monoesters in water and enhancement effect on skin permeation of 5-FU. Takahashi K, Komai M, Kinoshita N, et al. J. Pharm. Pharmacol. 63(8), 1008-14, (2011)

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Development and application of a validated stability-indicating high-performance liquid chromatographic method using photodiode array detection for simultaneous determination of granisetron, methylparaben, propylparaben, sodium benzoate, and their main degradation products in oral pharmaceutical preparations. Hewala I, El-Fatatry H, Emam E, et al. J. AOAC Int. 94(5), 1447-60, (2011)

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Efficiency of biological activator formulated material (BAFM) for volatile organic compounds removal--preliminary batch culture tests with activated sludge. Corre C, Couriol C, Amrane A, et al. Environ. Technol. 33(13-15), 1671-6, (2012)

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The first Korean case of lysinuric protein intolerance: presented with short stature and increased somnolence. Ko JM, Shin CH, Yang SW, et al. J. Korean Med. Sci. 27(8), 961-4, (2012)

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Novel UV-spectrophotometric method for quantitative estimation of furazolidone using mixed hydrotropic agent. Jain N, Jain R, Jain DK, et al. Pak. J. Pharm. Sci. 26(1), 159-62, (2013)

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DNA content alterations in Tetrahymena pyriformis macronucleus after exposure to food preservatives sodium nitrate and sodium benzoate. Loutsidou AC, Hatzi VI, Chasapis CT, et al. Acta Biol. Hung. 63(4), 483-9, (2012)

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Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate. Nair B Int. J. Toxicol. 20 Suppl 3, 23-50, (2001)

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Sodium benzoate, a D-amino acid oxidase inhibitor, increased volumes of thalamus, amygdala, and brainstem in a drug-naïve patient with major depression. Lai CH J. Neuropsychiatry Clin. Neurosci. 25(1), E50-1, (2013)

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Siderophore-producing bacteria from a sand dune ecosystem and the effect of sodium benzoate on siderophore production by a potential isolate. Gaonkar T, Nayak PK, Garg S, et al. ScientificWorldJournal 2012, 857249, (2012)

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Clinical and cerebral volumetric effects of sodium benzoate, a D-amino acid oxidase inhibitor, in a drug-naïve patient with major depression. Lai CH, Lane HY, and Tsai GE Biol. Psychiatry 71(4), e9-e10, (2012)

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Merck 14,8582

Beil. 9,IV,273

Fieser 1,1044 / Fieser 2,377

Aldrich MSDS 1, 160:C / Arctander, 2849 / Corp MSDS 1 (1), 361:C / FT-IR 1 (2), 271:B / FT-IR 2 (2), 2780:D / FT-NMR 1 (2), 1199:A / IR-Spectra (3), 1012:E / IR-Spectra (2), 886:F / RegBook 49 (2), 1863:A / RegBook 1 (2), 1863:A / Sax 6, 2413 / Sigma FT-IR 1 (2), 306:D / Structure Index 1, 299:C:1

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