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W398500 Aldrich

Salicylic acid

≥99%, FG

Synonym: 2-Hydroxybenzoic acid

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Properties

Related Categories Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products,
biological source   synthetic
grade   FG
  Halal
  Kosher
  follows IFRA guidelines
reg. compliance   EU Regulation 1223/2009
  FDA 21 CFR (175.105)
  FDA 21 CFR (175.300)
  FDA 21 CFR (177.2600)
  EU Regulation 1334/2008 & 178/2002
vapor density   4.8 (vs air)
vapor pressure   1 mmHg ( 114 °C)
assay   ≥99%
bp   211 °C(lit.)
mp   158-161 °C(lit.)
  158-162 °C
Organoleptic   phenolic
food allergen   no known allergens
fragrance allergen   no known allergens
Gene Information   human ... ALB(213), PTPN1(5770)

Description

Packaging

1 kg in poly bottle

10, 25 kg in fiber drum

Other Notes

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Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
WGK Germany 
1
RTECS 
VO0525000
Flash Point(F) 
314.6 °F
Flash Point(C) 
157 °C

Protocols & Articles

Articles

Determination of Water Content in Salicylic acid Using Karl Fischer Titration

Phenols behave differently. Most of them can be titrated in the usual manner, some are oxidized by iodine. o-Cresol shows a slight tendency towards oxidation, divalent phenols are easily oxidized. Py...
Keywords: Oxidations, Pharmaceutical, Titrations

Securing a Traceable Supply Chain for Food Grade Flavor Ingredients

Introduction Defining "Food Grade" Understanding "Food Grade" Versus "Industrial Grade" Top Questions to Ask a Flavor & Fragrances Supplier The Sigma-Aldrich Approach
Keywords: Food & Beverage, Food Safety, Solvents

Understanding the Complexities of Kosher Ingredients

Dr. Luke Grocholl, Quality Assurance Supervisor, Sigma-Aldrich Flavors & Fragrances and Rabbi Gershon Segal
Keywords: Fermentation, Food & Beverage, Safety industry

Peer-Reviewed Papers

References

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Systemic acquired resistance: turning local infection into global defense. Fu ZQ and Dong X Annu. Rev. Plant Biol. 64, 839-63, (2013)

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The Arabidopsis Rho of plants GTPase AtROP6 functions in developmental and pathogen response pathways. Poraty-Gavra L, Zimmermann P, Haigis S, et al. Plant Physiol. 161(3), 1172-88, (2013)

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Salicylic acid interferes with clathrin-mediated endocytic protein trafficking. Du Y, Tejos R, Beck M, et al. Proc. Natl. Acad. Sci. U. S. A. 110(19), 7946-51, (2013)

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Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Markus Fridén et al J. Med. Chem. 52, 6233-43, (2009)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1, S1-254, (2009)

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Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids. Kvitvang HF, Andreassen T, Adam T, et al. Anal. Chem. 83(7), 2705-11, (2011)

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Disappearance kinetics of solutes from synovial fluid after intra-articular injection. Owen SG, Francis HW, and Roberts MS Br. J. Clin. Pharmacol. 38(4), 349-55, (1994)

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Weights in the balance: jasmonic acid and salicylic acid signaling in root-biotroph interactions. Gutjahr C and Paszkowski U Mol. Plant Microbe Interact. 22(7), 763-72, (2009)

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Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human dermis. Benfeldt E, Serup J, and Menné T Acta Derm. Venereol. 79(5), 338-42, (1999)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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Determination of salicylate, gentisic acid and salicyluric acid in human urine by capillary electrophoresis with laser-induced fluorescence detection. Zaugg S, Zhang X, Sweedler J, et al. J. Chromatogr. B. Biomed. Sci. Appl. 752(1), 17-31, (2001)

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Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Alessio Innocenti et al Bioorg. Med. Chem. 16, 7424-8, (2008)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Elevated early callose deposition results in complete penetration resistance to powdery mildew in Arabidopsis. Ellinger D, Naumann M, Falter C, et al. Plant Physiol. 161(3), 1433-44, (2013)

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Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid. Loretta Lazzarato et al J. Med. Chem. 51, 1894-903, (2008)

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Does acetyl salicylic acid (ASA) have a role in the prevention of venous thromboembolism? Karthikeyan G, Eikelboom JW, Turpie AG, et al. Br. J. Haematol. 146(2), 142-9, (2009)

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The effects of host defence elicitors on betacyanin accumulation in Amaranthus mangostanus seedlings. Cao S, Liu T, Jiang Y, et al. Food Chem. 134(4), 1715-8, (2012)

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Identification and characterization of a novel chloroplast/mitochondria co-localized glutathione reductase 3 involved in salt stress response in rice. Wu TM, Lin WR, Kao YT, et al. Plant Mol. Biol. 83(4-5), 379-90, (2013)

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[Therapy of rheumatic disease with a hydroxyethylsalicylate gel. Results of 2 clinical studies of effectiveness and bioavailability]. Rutner M, Fitzek J, Jahnel-Kracht H, et al. Fortschr. Med. 113(8), 111-3, (1995)

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Regulation of auxin, abscisic acid and salicylic acid levels by ascorbate application under heat stress in sensitive and tolerant maize leaves. Dinler BS, Demir E, and Kompe YO Acta Biol. Hung. 65(4), 469-80, (2014)

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[10-year-old boy with blackish brown skin alterations]. Guarneri C, Tchernev G, Chokoeva AA, et al. Dtsch. Med. Wochenschr. 139(50), 2585-6, (2014)

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Profiling of secondary metabolites in root exudates of Arabidopsis thaliana. Strehmel N, Böttcher C, Schmidt S, et al. Phytochemistry 108, 35-46, (2014)

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[Regulation effects of intracellular and extracellular Ca2+ on biosynthesis of rosmarinic acid induced by salicylic acid in young seedlings of Salvia miltiorrhiza]. Cao RR, Dang XL, Xing BY, et al. Zhongguo Zhong Yao Za Zhi 38(20), 3424-31, (2013)

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[Viral warts on hands and feet are often self-limiting]. Nordentoft EL and Waldorf FB Ugeskr. Laeg. 175(22), 1559-61, (2013)

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[Chemical constituents of Gentiana rhodantha]. Chen Y, Wang GK, Wu C, et al. Zhongguo Zhong Yao Za Zhi 38(3), 362-5, (2013)

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Involvement of lectin in the salicylic acid-induced wheat tolerance to cadmium and the role of endogenous ABA in the regulation of its level. Shakirova FM, Bezrukova MV, Yuldashev RA, et al. Dokl. Biol. Sci. 448, 49-51, (2013)

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GbWRKY1, a novel cotton (Gossypium barbadense) WRKY gene isolated from a bacteriophage full-length cDNA library, is induced by infection with Verticillium dahliae. Shu-Ling Z, Xing-Fen W, Yan Z, et al. Indian J. Biochem. Biophys. 49(6), 405-13, (2012)

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In vitro inhibition of ?-carbonic anhydrase isozymes by some phenolic compounds. Sevim Beyza Oztürk Sarikaya et al Bioorg. Med. Chem. Lett. 21, 4259-62, (2011)

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Dissection of salicylic acid-mediated defense signaling networks. Lu H Plant Signal Behav. 4(8), 713-7, (2009)

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Biosynthesis of salicylic acid in plants. Chen Z, Zheng Z, Huang J, et al. Plant Signal Behav. 4(6), 493-6, (2009)

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Salicylic Acid, a multifaceted hormone to combat disease. Vlot AC, Dempsey DA, and Klessig DF Annu. Rev. Phytopathol. 47, 177-206, (2009)

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[Induced plant resistance and salicylic acid: a review]. Vasiukova NI and Ozeretskovskaia OL Prikl. Biokhim. Mikrobiol. 43(4), 405-11, (2007)

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Salicylic acid-, jasmonic acid- and ethylene-mediated regulation of plant defense signaling. Kachroo A and Kachroo P Genet. Eng. (N.Y.) 28, 55-83, (2007)

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[Salicylic acid, aspirin]. Onouchi T, Horiuchi T, and Kinouchi T Nihon Rinsho. 62 Suppl 12, 392-4, (2004)

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[Identification and quantification of exogenous metabolites in biological liquids with new development in NMR spectroscopy in one and two dimensions]. Azaroual, Imbenotte M, Cartigny B, et al. Acta Clin. Belg. Suppl. 1, 97-100, (1999)

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Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Alessio Innocenti et al Bioorg. Med. Chem. Lett. 18, 3593-6, (2008)

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Salicylic acid in plant defence--the players and protagonists. Loake G and Grant M Curr. Opin. Plant Biol. 10(5), 466-72, (2007)

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The salicylic acid loop in plant defense. Shah J Curr. Opin. Plant Biol. 6(4), 365-71, (2003)

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In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Esra Bayram et al Bioorg. Med. Chem. 16, 9101-5, (2008)

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GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. Zhang K and Zuo Y J. Agric. Food Chem. 52(2), 222-7, (2004)

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Genetic requirements for signaling from an autoactive plant NB-LRR intracellular innate immune receptor. Roberts M, Tang S, Stallmann A, et al. PLoS Genet. 9(4), e1003465, (2013)

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Herbivore exploits orally secreted bacteria to suppress plant defenses. Chung SH, Rosa C, Scully ED, et al. Proc. Natl. Acad. Sci. U. S. A. 110(39), 15728-33, (2013)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Salicylate, a catalytic inhibitor of topoisomerase II, inhibits DNA cleavage and is selective for the α isoform. Bau JT, Kang Z, Austin CA, et al. Mol. Pharmacol. 85(2), 198-207, (2014)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Suction blister fluid histamine in fixed drug eruption. Alanko K, Stubb S, Salo OP, et al. Acta Derm. Venereol. 72(2), 89-91, (1992)

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Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach J. A. Jacobsen, et al., J. Med. Chem. 54, 591-602, (2011)

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Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity. Gupta V, Liu S, Ando H, et al. Mol. Pharmacol. 84(6), 824-33, (2013)

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Salicylic acid: an old hormone up to new tricks. Boatwright JL and Pajerowska-Mukhtar K Mol. Plant Pathol. 14(6), 623-34, (2013)

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Salicylic acid and its function in plant immunity. An C and Mou Z J. Integr. Plant Biol. 53(6), 412-28, (2011)

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Salicylic acid beyond defence: its role in plant growth and development. Rivas-San Vicente M and Plasencia J J. Exp. Bot. 62(10), 3321-38, (2011)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating salicylic acid catabolism. Zhang K, Halitschke R, Yin C, et al. Proc. Natl. Acad. Sci. U. S. A. 110(36), 14807-12, (2013)

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Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. Schmook FP, Meingassner JG, and Billich A Int. J. Pharm. 215(1-2), 51-6, (2001)

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Prediction of cathodal iontophoretic transport of various anions across excised skin from different vehicles using conductivity measurements. Yoshida NH and Roberts MS J. Pharm. Pharmacol. 47(11), 883-90, (1995)

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Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Gronwald W, Klein MS, Zeltner R, et al. Kidney Int. 79(11), 1244-53, (2011)

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Crosstalk between intracellular and extracellular salicylic acid signaling events leading to long-distance spread of signals. Kawano T and Bouteau F Plant Cell Rep. 32(7), 1125-38, (2013)

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A general palladium-catalyzed carbonylative synthesis of chromenones from salicylic aldehydes and benzyl chlorides. Wu XF, Wu L, Jackstell R, et al. Chemistry 19(37), 12245-8, (2013)

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A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. David Buttar et al Bioorg. Med. Chem. 18, 7486-96, (2010)

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Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies. Gamze Bora-Tatar et al Bioorg. Med. Chem. 17, 5219-28, (2009)

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Synthesis, antimicrobial, and QSAR studies of substituted benzamides. Anil Kumar et al Bioorg. Med. Chem. 15, 4113-24, (2007)

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Uncoupling of reactive oxygen species accumulation and defence signalling in the metal hyperaccumulator plant Noccaea caerulescens. Fones HN, Eyles CJ, Bennett MH, et al. New Phytol. 199(4), 916-24, (2013)

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Salicylic acid activates DNA damage responses to potentiate plant immunity. Yan S, Wang W, Marqués J, et al. Mol. Cell. 52(4), 602-10, (2013)

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Overexpression of L-type lectin-like protein kinase 1 confers pathogen resistance and regulates salinity response in Arabidopsis thaliana. Huang P, Ju HW, Min JH, et al. Plant Sci. 203-204, 98-106, (2013)

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Pityriasis folliculorum: a novel therapy for a diagnostically challenging condition. Tinklepaugh AJ and Wilson BB J. Am. Acad. Dermatol. 69(5), e276-7, (2013)

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Efficient synthesis of anacardic acid analogues and their antibacterial activities. Mamidyala SK, Ramu S, Huang JX, et al. Bioorg. Med. Chem. Lett. 23(6), 1667-70, (2013)

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The calmodulin-like protein CML43 functions as a salicylic-acid-inducible root-specific Ca(2+) sensor in Arabidopsis. Bender KW, Dobney S, Ogunrinde A, et al. Biochem. J. 457(1), 127-36, (2014)

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Enhanced photoluminescence by tyrosine-containing bolaamphiphile self-assembly. Kwak J and Lee SY Langmuir 29(14), 4477-84, (2013)

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The role of salicylic acid and jasmonic acid in pathogen defence. Halim VA, Vess A, Scheel D, et al. Plant Biol. (Stuttg.) 8(3), 307-13, (2006)

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An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. Myrielle Dupont et al Antimicrob. Agents Chemother. 51, 3190-8, (2007)

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Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Loretta Aureli et al J. Med. Chem. 48, 2469-79, (2005)

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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Gregory Kaler et al J. Biol. Chem. 282, 23841-53, (2007)

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3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors. Chao-Bin Xue et al Bioorg. Med. Chem. 15, 2006-15, (2007)

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Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Baggott JE, Morgan SL, Ha T, et al. Biochem. J. 282 ( Pt 1), 197-202, (1992)

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Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)

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Transdermal iontophoresis and solute penetration across excised human skin. Singh P, Anliker M, Smith GA, et al. J. Pharm. Sci. 84(11), 1342-6, (1995)

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Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method. Ndovi TT, Choi L, Caffo B, et al. Clin. Pharmacol. Ther. 80(2), 146-58, (2006)

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Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. Babasaheb P Bandgar et al Bioorg. Med. Chem. Lett. 20, 730-3, (2010)

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Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans. Loretta Lazzarato et al Bioorg. Med. Chem. 19, 5852-60, (2011)

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Arabidopsis thaliana FLOWERING LOCUS D is required for systemic acquired resistance. Singh V, Roy S, Giri MK, et al. Mol. Plant Microbe Interact. 26(9), 1079-88, (2013)

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Co-synergism of endophyte Penicillium resedanum LK6 with salicylic acid helped Capsicum annuum in biomass recovery and osmotic stress mitigation. Khan AL, Waqas M, Hamayun M, et al. BMC Microbiol. 13, 51, (2013)

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Elevated CO2 increases the abundance of the peach aphid on Arabidopsis by reducing jasmonic acid defenses. Sun Y, Guo H, Zhu-Salzman K, et al. Plant Sci. 210, 128-40, (2013)

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Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signalling. Laird J, McInally C, Carr C, et al. J. Gen. Virol. 94(Pt 12), 2777-89, (2013)

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Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease. Suneela S Dhaneshwar et al Eur. J. Med. Chem. 44, 3922-9, (2009)

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Locally delivered salicylic acid from a poly(anhydride-ester): impact on diabetic bone regeneration. Wada K, Yu W, Elazizi M, et al. J. Control. Release 171(1), 33-7, (2013)

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Response to metal stress of Nicotiana langsdorffii plants wild-type and transgenic for the rat glucocorticoid receptor gene. Fuoco R, Bogani P, Capodaglio G, et al. J. Plant Physiol. 170(7), 668-75, (2013)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line. Kekuda R, Manoharan P, Baseler W, et al. Dig. Dis. Sci. 58(3), 660-7, (2013)

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Reactive oxygen species promote chloroplast dysfunction and salicylic acid accumulation in fumonisin B1-induced cell death. Xing F, Li Z, Sun A, et al. FEBS Lett. 587(14), 2164-72, (2013)

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A salicylic acid-induced lectin-like protein plays a positive role in the effector-triggered immunity response of Arabidopsis thaliana to Pseudomonas syringae Avr-Rpm1. Armijo G, Salinas P, Monteoliva MI, et al. Mol. Plant Microbe Interact. 26(12), 1395-406, (2013)

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Salicylic acid determines differential senescence produced by two Turnip mosaic virus strains involving reactive oxygen species and early transcriptomic changes. Manacorda CA, Mansilla C, Debat HJ, et al. Mol. Plant Microbe Interact. 26(12), 1486-98, (2013)

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Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1. Peter J McNamara et al Antimicrob. Agents Chemother. 53, 1898-906, (2009)

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Reduction in the fitness of Bemisia tabaci fed on three previously infested tomato genotypes differing in the jasmonic acid pathway. Cui H, Sun Y, Su J, et al. Environ. Entomol. 41(6), 1443-53, (2012)

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False-high blood salicylate levels in neonates with hyperbilirubinemia. Berkovitch M, Uziel Y, Greenberg R, et al. Ther. Drug Monit. 22(6), 757-61, (2000)

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Pattern-triggered immunity suppresses programmed cell death triggered by fumonisin b1. Igarashi D, Bethke G, Xu Y, et al. PLoS ONE 8(4), e60769, (2013)

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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Ashley A Reinke et al Bioorg. Med. Chem. Lett. 19, 4952-7, (2009)

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Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity. Suja Shrestha et al Bioorg. Med. Chem. 16, 8643-52, (2008)

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Pharmacokinetic investigations with direct injection of plasma samples: possible savings using capillary electrophoresis (CE). Kunkel A and Wätzig H Arch. Pharm. (Weinheim) 332(5), 175-8, (1999)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Role of salicylic acid in plant abiotic stress. Yuan S and Lin HH Z. Naturforsch. C 63(5-6), 313-20, (2008)

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Elevated carbon dioxide increases salicylic acid in Glycine max. Casteel CL, Segal LM, Niziolek OK, et al. Environ. Entomol. 41(6), 1435-42, (2012)

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Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives. Francesco Epifano et al Bioorg. Med. Chem. Lett. 17, 5709-14, (2007)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Effects of salicylates on evoked otoacoustic emissions and remote masking in humans. Quaranta A, Portalatini P, Camporeale M, et al. Audiology 38(3), 174-9, (1999)

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Salicylic acid increases the contents of glutathione and ascorbate and temporally regulates the related gene expression in salt-stressed wheat seedlings. Li G, Peng X, Wei L, et al. Gene 529(2), 321-5, (2013)

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Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-? dependent NF?B activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis. Jihye Kim et al Eur. J. Med. Chem. 48, 36-44, (2012)

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Rpi-blb2-mediated late blight resistance in Nicotiana benthamiana requires SGT1 and salicylic acid-mediated signaling but not RAR1 or HSP90. Oh SK, Kim H, and Choi D FEBS Lett. 588(7), 1109-15, (2014)

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Acetylsalicylic acid (aspirin) and salicylic acid interaction with the human erythrocyte membrane bilayer induce in vitro changes in the morphology of erythrocytes. Suwalsky M, Belmar J, Villena F, et al. Arch. Biochem. Biophys. 539(1), 9-19, (2013)

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Transgenic tomato plants overexpressing tyramine N-hydroxycinnamoyltransferase exhibit elevated hydroxycinnamic acid amide levels and enhanced resistance to Pseudomonas syringae. Campos L, Lisón P, López-Gresa MP, et al. Mol. Plant Microbe Interact. 27(10), 1159-69, (2014)

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Positive and negative roles for soybean MPK6 in regulating defense responses. Liu JZ, Braun E, Qiu WL, et al. Mol. Plant Microbe Interact. 27(8), 824-34, (2014)

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GH3 expression and IAA-amide synthetase activity in pea (Pisum sativum L.) seedlings are regulated by light, plant hormones and auxinic herbicides. Ostrowski M and Jakubowska A J. Plant Physiol. 170(4), 361-8, (2013)

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Real-time monitoring on the adsorption process of salicylic acid onto chitosan membrane using dielectric spectroscopy: macroscale concentration polarization and dynamics. Li Y, Gao W, Zhao K, et al. J. Phys. Chem. B 117(12), 3337-44, (2013)

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Inhibition of IKK-beta: a new development in the mechanism of the anti-obesity effects of PTP1B inhibitors SA18 and SA32. Bharat Raj Bhattarai et al Bioorg. Med. Chem. Lett. 20, 1075-7, (2010)

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Evaluation of the efficacy, tolerability, and safety of an over-the-counter acne regimen containing benzoyl peroxide and salicylic acid in subjects with acne. Kircik LH, Gwazdauskas J, Butners V, et al. Journal. of. Drugs in. Dermatology. 12(3), 259-64, (2013)

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Single-center, open-label study of a proprietary topical 0.5% salicylic acid-based treatment regimen containing sandalwood oil in adolescents and adults with mild to moderate acne. Moy RL, Levenson C, So JJ, et al. Journal. of. Drugs in. Dermatology. 11(12), 1403-8, (2012)

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8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors. Thorsten E Fisher et al Bioorg. Med. Chem. Lett. 17, 6511-5, (2007)

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Synovial distribution of "systemically" administered acetylsalicylic acid in the isolated perfused equine distal limb. Friebe M, Schumacher S, Stahl J, et al. BMC Vet. Res. 9, 56, (2013)

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Efficient synthesis of (+/-)-parasitenone, a novel inhibitor of NF-kappaB. Tsuyoshi Saitoh et al Bioorg. Med. Chem. Lett. 19, 5383-6, (2009)

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Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids. Wendy R Russell et al Bioorg. Med. Chem. 16, 4589-93, (2008)

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A note on the use of salicylate saliva concentration in clinical pharmacokinetic studies. Khan AZ and Aarons L J. Pharm. Pharmacol. 41(10), 710-1, (1989)

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Benzenepolycarboxylic acids with potential anti-hemorrhagic properties and structure-activity relationships. Hnin Thanda Aung et al Bioorg. Med. Chem. 19, 7000-2, (2011)

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Silencing of TaBTF3 gene impairs tolerance to freezing and drought stresses in wheat. Kang G, Ma H, Liu G, et al. Mol. Genet. Genomics 288(11), 591-9, (2013)

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Salicylic acid-mediated establishment of the compatibility between Alternaria brassicicola and Brassica juncea is mitigated by abscisic acid in Sinapis alba. Mazumder M, Das S, Saha U, et al. Plant Physiol. Biochem. 70, 43-51, (2013)

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Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba. Hao G, Shi R, Tao R, et al. Plant Physiol. Biochem. 70, 21-32, (2013)

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Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone. Dahl A, Yatskayer M, Raab S, et al. Journal. of. Drugs in. Dermatology. 12(1), 52-8, (2013)

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The physiological and biochemical effects of salicylic acid on sunflowers (Helianthus annuus) exposed to flurochloridone. Kaya A and Yigit E Ecotoxicol. Environ. Saf. 106, 232-8, (2014)

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Randomized, controlled, evaluator-blinded studies conducted to compare the efficacy and tolerability of 3 over-the-counter acne regimens in subjects with mild or moderate acne. Green L, Kircik LH, and Gwazdauskas J Journal. of. Drugs in. Dermatology. 12(2), 180-5, (2013)

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Military aircrew and noise-induced hearing loss: prevention and management. Rajguru R Aviat. Space. Environ. Med. 84(12), 1268-76, (2013)

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Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis. Scheit K and Bauer G Anticancer Res. 34(10), 5337-50, (2014)

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A review of toxicity from topical salicylic acid preparations. Madan RK and Levitt J J. Am. Acad. Dermatol. 70(4), 788-92, (2014)

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Commentary: salicylic acid peels versus Jessner's solution peels for acne vulgaris: a comparative study. Monheit G Dermatol. Surg. 39(2), 253-4, (2013)

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Acne & rosacea: thinking outside the box. Shalita AR and Bowe WP Journal. of. Drugs in. Dermatology. 11(12), 1400, (2012)

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Plant autophagy puts the brakes on cell death by controlling salicylic acid signaling. Yoshimoto K Autophagy 6(1), 192-3, (2010)

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Merck 14,8332

Beil. 10,IV,125

Aldrich MSDS 1, 1595:C / Corp MSDS 1 (2), 3065:D / FT-IR 1 (2), 188:C / FT-IR 2 (2), 2650:B / FT-NMR 1 (2), 1065:C / IR-Spectra (2), 838:D / IR-Spectra (3), 957:G / NMR-Reference 2 (2), 185:A / RegBook 1 (2), 1783:L / Sigma FT-IR 1 (2), 886:B / Structure Index 1, 284:B:8 / Vapor Phase 3, 1324:A

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