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Z249491 Aldrich

Protocols For Oligonucleotide Conjugates: Synthesis and Analytical Techniques

  •  ISBN-10 0896032523

  •  ISBN-13 978-089603252-1

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publication info   S. Agrawal, Humana Press, 1993, 377 pp., soft cover
mfr. no.   Humana

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General description

Leading researchers provide the latest protocols for synthesizing oligonucleotide conjugates and explain the latest techniques for analyzing them. These techniques are widely used by pharmaceutical companies as part of the permit process for new drugs. They are also useful to molecular biologists and antisense researchers. Each protocol includes an introduction, a list of materials (including suppliers), step-by-step instructions, and notes for avoiding pitfalls and achieving the best results

Table of Contents

Preface v
Foreword vii
Companion Volume Contents xi
Contributors xiii
CH. 1. Protecting Groups in Oligonucleotide Synthesis, 1
CH. 2. Incorporation of Modified Bases into Oligonucleotides, 73
CH. 3. Functionalization of Oligonucleotides with Amino Groups
and Attachment of Amino Specific Reporter Groups, 93
CH. 4. Functionalization of Oligonucleotides
by the Incorporation of Thio-Specific Reporter Groups, 121
CH. 5. Postsynthesis Functionalization of Oligonucleotides, 145
CH. 6. Oligonucleotide-Enzyme Conjugates, 167
CH. 7. Oligonucleotides Containing Degenerate Bases:
Synthesis and Uses, 187
CH. 8. Synthesis of (15N)-Labeled DNA Fragments, 207
CH. 9. Analysis and Purification of Synthetic Oligonucleotides
by High-Performance Liquid Chromatography, 233
CH. 10. Sequence Analysis of Oligodeoxyribonucleotides, 265
CH. 11. Gel-Capillary Electrophoresis Analysis of Oligonucleotides, 277
CH. 12. Nuclear Magnetic Resonance Studies of Oligonucleotides, 301
CH. 13. Mass Spectrometry of Nucleotides and Oligonucleotides, 319
CH. 14. Extracting Thermodynamic Data from Equilibrium Melting Curves for
Oligonucleotide Order-Disclosure Transitions, 347
Index 373

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