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Z287628 Aldrich

Impact of Stereochemistry on Drug Development and Use

  •  ISBN-10 0471596442

  •  ISBN-13 978-047159644-8

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publication info   H. Aboul-Enein, John Wiley & Sons, Ltd, 1997, hard cover
mfr. no.   Wiley

Description

General description

This book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmaceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops.

Table of Contents

Partial Table of Contents:
Chirality and Drug Hazards.
Stereochemical Aspects of Drug Metabolism.
Some Examples for Stereoselective Biotransformation of Drugs.
Chiral Barbiturates: Synthesis, Chromatographic Resolutions, and Biological Activity.
Stereogenic Elements of Pharmaceutical Compounds: Some Aspects on Isomerism, Resolution, and Stereochemical Integrity.
The Importance of Chiral Separations in Pharmaceuticals.
Micelle-Mediated Capillary Electrophoretic Separation of Enantiomeric Compounds.
Chiral Derivatization Reagents in the Bioanalysis of Optically Active Drugs with Chromophore-Based Detection.
Circular Dichroism in the Study of Stereoselective Binding of Drugs to Serum Proteins.

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