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11365 Fluka

Avicel® PH-101

~50 μm particle size

Synonym: Cellulose microcrystalline, Cellulose powder, Cellulose, Cotton linters

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Description

Frequently Asked Questions

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Application

High purity cellulose powders for partition chromatography.

• Avicel® PH-101 was used as reference material in characterisation of microcrystalline cellulose (MCC) using Powder X-ray diffraction and Fourier transform infrared spectroscopy.1
• Avicel® PH-101 was used to evaluate crystallinity index and spectral analysis of cellulose using XRD and solid-state 13C NMR.2
• Avicel® PH-101 was used in preparation of phosphoric acid-swollen cellulose for enzyme assay using HPLC.3

Legal Information

Avicel is a registered trademark of FMC Corp.

Price and Availability

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Safety & Documentation

Safety Information

WGK Germany 
3
RTECS 
FJ5691460

Protocols & Articles

Articles

Determination of Water Content in Cellulose fibrous Using Karl Fischer Titration

Carbohydrates comprise diverse compounds, mono-, di- and polysaccharides. Mono- and disaccharides dissolve in Methanol or solvent mixtures and can thus be titrated. If only adherent water is to be de...
Keywords: Pharmaceutical, Titrations

Determination of Water Content in Cellulose microcrystalline Using Karl Fischer Titration

Carbohydrates comprise diverse compounds, mono-, di- and polysaccharides. Mono- and disaccharides dissolve in Methanol or solvent mixtures and can thus be titrated. If only adherent water is to be de...
Keywords: Pharmaceutical, Titrations

Peer-Reviewed Papers

References

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3. Synergistic saccharification, and direct fermentation to ethanol, of amorphous cellulose by use of an engineered yeast strain codisplaying three types of cellulolytic enzyme. Fujita Y, Ito J, Ueda M, et al. Appl. Environ. Microbiol. 70(2), 1207-12, (2004)

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Bacterial cellulose scaffolds and cellulose nanowhiskers for tissue engineering. Dugan JM, Gough JE, and Eichhorn SJ Nanomedicine (Lond.) 8(2), 287-98, (2013)

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The physicochemical characteristic of microcrystalline cellulose, derived from sawdust, agricultural waste products Oyeniyi, Y. J., and O. A. Itiola. Int. J. Pharm. Pharmaceut Sci. 4, 197-200, (2012)

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The slowdown of the endoglucanase Trichoderma reesei Cel5A-catalyzed cellulose hydrolysis is related to its initial activity. Shu Z, Wang Y, An L, et al. Biochemistry 53(48), 7650-8, (2014)

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Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets. Chen H, Wang W, Degroote J, et al. J. Nutr. 145(1), 51-8, (2015)

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Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history. Zhou X, Wang B, Pan Q, et al. Nat. Genet. 46(12), 1303-10, (2014)

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The Arabidopsis COBRA protein facilitates cellulose crystallization at the plasma membrane. Sorek N, Sorek H, Kijac A, et al. J. Biol. Chem. 289(50), 34911-20, (2014)

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Vertebral osteolytic defect due to cellulose particles derived from gauze fibers after posterior lumbar interbody fusion. Takenaka S, Mukai Y, Hosono N, et al. J. Neurosurg. Spine 21(6), 877-81, (2014)

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Renewable Energy. Cellulosic ethanol at last? Service RF Science 345(6201), 1111, (2014)

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Flocculation causes inhibitor tolerance in Saccharomyces cerevisiae for second-generation bioethanol production. Westman JO, Mapelli V, Taherzadeh MJ, et al. Appl. Environ. Microbiol. 80(22), 6908-18, (2014)

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Extracellular secretion of noncatalytic plant cell wall-binding proteins by the cellulolytic thermophile Caldicellulosiruptor bescii. Yokoyama H, Yamashita T, Morioka R, et al. J. Bacteriol. 196(21), 3784-92, (2014)

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Adsorption of hydrogen sulphide from aqueous solutions using modified nano/micro fibrillated cellulose. Hokkanen S, Repo E, Bhatnagar A, et al. Environ. Technol. 35(17-20), 2334-46, (2014)

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The disulfide bonding system suppresses CsgD-independent cellulose production in Escherichia coli. Hufnagel DA, DePas WH, and Chapman MR J. Bacteriol. 196(21), 3690-9, (2014)

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Development and validation of a liquid chromatographic method for the stability study of a pharmaceutical formulation containing voriconazole using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector and polar organic mobile phases. Servais AC, Moldovan R, Farcas E, et al. J. Chromatogr. A 1363, 178-82, (2014)

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Comment on "Revealing nature's cellulase diversity: the digestion mechanism of Caldicellulosiruptor bescii CelA". Gusakov AV Science 344(6184), 578, (2014)

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Autonomous bottom-up fabrication of three-dimensional nano/microcellulose honeycomb structures, directed by bacterial nanobuilder. Kondo T and Kasai W J. Biosci. Bioeng. 118(4), 482-7, (2014)

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Probing of exopolysaccharides with green fluorescence protein-labeled carbohydrate-binding module in Escherichia coli biofilms and flocs induced by bcsB overexpression. Nguyen MH, Ojima Y, Sakka M, et al. J. Biosci. Bioeng. 118(4), 400-5, (2014)

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Deterministic processes guide long-term synchronised population dynamics in replicate anaerobic digesters. Vanwonterghem I, Jensen PD, Dennis PG, et al. ISME J. 8(10), 2015-28, (2014)

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Bioconversion of oil palm frond by Aspergillus niger to enhances it's fermentable sugar production. Lim SH and Ibrahim D Pak. J. Biol. Sci. 16(18), 920-6, (2013)

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[Cellulolytic activity of Fenellia flavipes and Fusarium oxysporum strains]. Chepchak TP, Olishevskaia SV, and Kurchenko IN Mikrobiol. Z. 75(6), 51-8, (2013)

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Linking cellulose fiber sediment methyl mercury levels to organic matter decay and major element composition. Regnell O, Elert M, Höglund LO, et al. Ambio 43(7), 878-90, (2014)

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Use of statistical modeling to predict the effect of formulation composition on conditioning shampoo performance. Lepilleur C, Giovannitti-Jensen A, and Kyer C J. Cosmet. Sci. 64(6), 411-27, (2013)

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Microbiology. No barriers to cellulose breakdown. Berlin A Science 342(6165), 1454-6, (2013)

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Chemical and morphological changes in hydrochars derived from microcrystalline cellulose and investigated by chromatographic, spectroscopic and adsorption techniques. Diakité M, Paul A, Jäger C, et al. Bioresour. Technol. 150, 98-105, (2013)

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[Genes for cellulose-degradation and their expression conditions in Chaetomium globosum NK102]. Hu Y, Bi J, Hao X, et al. Wei Sheng Wu Xue Bao 53(4), 354-62, (2013)

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Evaluation the reflection coefficient of polymeric membrane in concentration polarization conditions. Batko K, Slezak-Prochazka I, and Slezak A Polim. Med. 43(1), 11-9, (2013)

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[Molecular mechanism of AtGA3OX1 and AtGA3OX2 genes affecting secondary wall thickening in stems in Arabidopsis]. Wang ZG, Chai GH, Wang ZY, et al. Yi Chuan 35(5), 655-65, (2013)

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Screening and identification of newly isolated cellulose-degrading bacteria from the gut of xylophagous termite Microcerotermes diversus (Silvestri). Pourramezan Z, Ghezelbash GR, Romani B, et al. Mikrobiologiia 81(6), 796-802, (2012)

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Battle for the barrel. Service RF Science 339(6126), 1374-7, 1379, (2013)

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[Utilization of carbon sources by Fusarium poae (Peck) Wollenw. Strains from different trophic groups]. Kurchenko IN, Vasilevskaia AI, Artyshkova LV, et al. Mikrobiol. Z. 75(1), 54-68, (2013)

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Mineral stress affects the cell wall composition of grapevine (Vitis vinifera L.) callus. Fernandes JC, García-Angulo P, Goulao LF, et al. Plant Sci. 205-206, 111-20, (2013)

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Ionic liquid processing of cellulose. Wang H, Gurau G, and Rogers RD Chem. Soc. Rev. 41(4), 1519-37, (2012)

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Applications of functionalized and nanoparticle-modified nanocrystalline cellulose. Lam E, Male KB, Chong JH, et al. Trends Biotechnol. 30(5), 283-90, (2012)

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Electrospun cellulose acetate nanofibers: the present status and gamut of biotechnological applications. Konwarh R, Karak N, and Misra M Biotechnol. Adv. 31(4), 421-37, (2013)

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Cracking the elusive alignment hypothesis: the microtubule-cellulose synthase nexus unraveled. Bringmann M, Landrein B, Schudoma C, et al. Trends Plant Sci. 17(11), 666-74, (2012)

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One-pot conversion of cellulose to ethylene glycol with multifunctional tungsten-based catalysts. Wang A and Zhang T Acc. Chem. Res. 46(7), 1377-86, (2013)

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Microfibrillated cellulose - its barrier properties and applications in cellulosic materials: a review. Lavoine N, Desloges I, Dufresne A, et al. Carbohydr. Polym. 90(2), 735-64, (2012)

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Characterization of cellulose II nanoparticles regenerated from 1-butyl-3-methylimidazolium chloride. Han J, Zhou C, French AD, et al. Carbohydr. Polym. 94(2), 773-81, (2013)

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Production of nanocrystalline cellulose from lignocellulosic biomass: technology and applications. Brinchi L, Cotana F, Fortunati E, et al. Carbohydr. Polym. 94(1), 154-69, (2013)

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Structure and properties of polypyrrole/bacterial cellulose nanocomposites. Muller D, Rambo CR, Porto LM, et al. Carbohydr. Polym. 94(1), 655-62, (2013)

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Fusion of dioxygenase and lignin-binding domains in a novel secreted enzyme from cellulolytic Streptomyces sp. SirexAA-E. Bianchetti CM, Harmann CH, Takasuka TE, et al. J. Biol. Chem. 288(25), 18574-87, (2013)

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Combining computational chemistry and crystallography for a better understanding of the structure of cellulose. French AD Adv. Carbohydr. Chem. Biochem. 67, 19-93, (2012)

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Degradation and synthesis of β-glucans by a Magnaporthe oryzae endotransglucosylase, a member of the glycoside hydrolase 7 family. Takahashi M, Yoshioka K, Imai T, et al. J. Biol. Chem. 288(19), 13821-30, (2013)

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Shape control of cellulose nanocrystals via compositional acid hydrolysis. Baek C, Hanif Z, Cho SW, et al. J. Biomed. Nanotechnol. 9(7), 1293-8, (2013)

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Identification and characterization of non-cellulose-producing mutants of Gluconacetobacter hansenii generated by Tn5 transposon mutagenesis. Deng Y, Nagachar N, Xiao C, et al. J. Bacteriol. 195(22), 5072-83, (2013)

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Synthesis of flexible magnetic nanohybrid based on bacterial cellulose under ultrasonic irradiation. Zheng Y, Yang J, Zheng W, et al. Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4), 2407-12, (2013)

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Cellulose as an architectural element in spatially structured Escherichia coli biofilms. Serra DO, Richter AM, and Hengge R J. Bacteriol. 195(24), 5540-54, (2013)

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Microtubule and cellulose microfibril orientation during plant cell and organ growth. Chan J J. Microsc. 247(1), 23-32, (2012)

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Ethanol production from high cellulose concentration by the basidiomycete fungus Flammulina velutipes. Maehara T, Ichinose H, Furukawa T, et al. Fungal Biol. 117(3), 220-6, (2013)

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Location and contribution of individual β-glucosidase from Neurospora crassa to total β-glucosidase activity. Wu W, Kasuga T, Xiong X, et al. Arch. Microbiol. 195(12), 823-9, (2013)

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Review of cellulose nanocrystals patents: preparation, composites and general applications. Durán N, Lemes AP, and Seabra AB Recent Pat. Nanotechnol. 6(1), 16-28, (2012)

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Field emission properties of a graphene/polymer composite. Patole SP, Lee JH, Park JH, et al. J. Nanosci. Nanotechnol. 13(11), 7689-94, (2013)

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Revealing nature's cellulase diversity: the digestion mechanism of Caldicellulosiruptor bescii CelA. Brunecky R, Alahuhta M, Xu Q, et al. Science 342(6165), 1513-6, (2013)

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Nanocellulose patents trends: a comprehensive review on patents on cellulose nanocrystals, microfibrillated and bacterial cellulose. Charreau H, Foresti ML, and Vazquez A Recent Pat. Nanotechnol. 7(1), 56-80, (2013)

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X-ray scattering studies of lignocellulosic biomass: a review. Xu F, Shi YC, and Wang D Carbohydr. Polym. 94(2), 904-17, (2013)

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Nanofibrous rutile-titania/graphite composite derived from natural cellulose substance. Luo Y, Liu X, and Huang J J. Nanosci. Nanotechnol. 13(1), 582-8, (2013)

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Genomic analysis of Chthonomonas calidirosea, the first sequenced isolate of the phylum Armatimonadetes. Lee KC, Morgan XC, Dunfield PF, et al. ISME J. 8(7), 1522-33, (2014)

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Direct transfer of graphene onto flexible substrates. Martins LG, Song Y, Zeng T, et al. Proc. Natl. Acad. Sci. U. S. A. 110(44), 17762-7, (2013)

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The surface reactivity and implied toxicity of ash produced from sugarcane burning. Le Blond JS, Tomatis M, Horwell CJ, et al. Environ. Toxicol. 29(5), 503-16, (2014)

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Functional cellulose beads: preparation, characterization, and applications. Gericke M, Trygg J, and Fardim P Chem. Rev. 113(7), 4812-36, (2013)

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Lignin valorization: improving lignin processing in the biorefinery. Ragauskas AJ, Beckham GT, Biddy MJ, et al. Science 344(6185), 1246843, (2014)

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The cell biology of cellulose synthesis. McFarlane HE, Döring A, and Persson S Annu. Rev. Plant Biol. 65, 69-94, (2014)

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Chemically modified cellulose paper as a thin film microextraction phase. Saraji M and Farajmand B J. Chromatogr. A 1314, 24-30, (2013)

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Enzymatic transformation of nonfood biomass to starch. You C, Chen H, Myung S, et al. Proc. Natl. Acad. Sci. U. S. A. 110(18), 7182-7, (2013)

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Aspergillus niger β-glucosidase has a cellulase-like tadpole molecular shape: insights into glycoside hydrolase family 3 (GH3) β-glucosidase structure and function. Lima MA, Oliveira-Neto M, Kadowaki MA, et al. J. Biol. Chem. 288(46), 32991-3005, (2013)

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Optical, bactericidal and water repellent properties of electrospun nano-composite membranes of cellulose acetate and ZnO. Anitha S, Brabu B, John Thiruvadigal D, et al. Carbohydr. Polym. 97(2), 856-63, (2013)

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Overview of bacterial cellulose composites: a multipurpose advanced material. Shah N, Ul-Islam M, Khattak WA, et al. Carbohydr. Polym. 98(2), 1585-98, (2013)

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Efficient enzymatic hydrolysis of the bagasse pulp prepared with active oxygen and MgO-based solid alkali. Xie T, Lin L, Pang C, et al. Carbohydr. Polym. 94(2), 807-13, (2013)

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Sensitivity-enhanced solid-state NMR detection of expansin's target in plant cell walls. Wang T, Park YB, Caporini MA, et al. Proc. Natl. Acad. Sci. U. S. A. 110(41), 16444-9, (2013)

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Characterization of biomass residues and their amendment effects on water sorption and nutrient leaching in sandy soil. Wang L, Tong Z, Liu G, et al. Chemosphere 107, 354-9, (2014)

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BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. Omadjela O, Narahari A, Strumillo J, et al. Proc. Natl. Acad. Sci. U. S. A. 110(44), 17856-61, (2013)

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Transient kinetics and rate-limiting steps for the processive cellobiohydrolase Cel7A: effects of substrate structure and carbohydrate binding domain. Cruys-Bagger N, Tatsumi H, Ren GR, et al. Biochemistry 52(49), 8938-48, (2013)

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Plant cell wall engineering: applications in biofuel production and improved human health. Burton RA and Fincher GB Curr. Opin. Biotechnol. 26, 79-84, (2014)

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Differences in gastrointestinal calcium absorption after the ingestion of calcium-free phosphate binders. Behets GJ, Dams G, Damment SJ, et al. Am. J. Physiol. Renal Physiol. 306(1), F61-7, (2014)

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Silver nanowire catalysts on carbon nanotubes-incorporated bacterial cellulose membrane electrodes for oxygen reduction reaction. Kim B, Choi Y, Cho SY, et al. J. Nanosci. Nanotechnol. 13(11), 7454-8, (2013)

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Cellulosic binder-assisted formation of graphene-paper electrode with flat surface and porous internal structure. Lee CK, Lee SB, Hwang SW, et al. J. Nanosci. Nanotechnol. 13(11), 7391-5, (2013)

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Root growth is modulated by differential hormonal sensitivity in neighboring cells. Fridman Y, Elkouby L, Holland N, et al. Genes Dev. 28(8), 912-20, (2014)

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Characterization of enriched aerotolerant cellulose-degrading communities for biofuels production using differing selection pressures and inoculum sources. Wushke S, Levin DB, Cicek N, et al. Can. J. Microbiol. 59(10), 679-83, (2013)

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Evaluating thermophysiological comfort using the principles of sensory analysis. Cubrić IS and Skenderi Z Coll. Antropol. 37(1), 57-64, (2013)

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Cellulose triacetate as a high-performance membrane. Sunohara T and Masuda T Contrib. Nephrol. 173, 156-63, (2011)

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Acid-soluble internal capsules for closed-face cassette elemental sampling and analysis of workplace air. Harper M and Ashley K J. Occup. Environ. Hyg. 10(6), 297-306, (2013)

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Cyclodextrin-based combinatorial polymers: efficient binders of pharmaceuticals in water. Shahgaldian P and Corvini PF Chimia 67(6), 425-6, (2013)

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Repair of the donor areas defects after split-thickness skin grafts utilizing an advanced epithelialization dressing. Fanti PA, Dika E, Vaccari S, et al. J. Dermatolog. Treat. 25(5), 434-7, (2014)

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Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses. Muzíková J and Sináglová P Acta Pol. Pharm. 70(1), 129-35, (2013)

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In vitro studies on the beneficial effect of a hydrokinetic fiber dressing on wound healing by reduction of protease activity. Wiegand C and Hipler UC J. Wound Care 22(11), 592, 594-8, (2013)

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Overcoming the Recalcitrance for the Conversion of Kenaf Pulp to Glucose via Microwave-Assisted Pre-Treatment Processes. Beng Guat Ooi et al Int. J. Mol. Sci. 12, 1451-63, (2011)

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A physics-based temperature model for ultrasonic vibration-assisted pelleting of cellulosic biomass. Song X, Yu X, Zhang M, et al. Ultrasonics 54(7), 2042-9, (2014)

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A study of micronized poloxamers as lubricants in direct compression of tablets. Muzíková J, Vyhlídalová B, and Pekárek T Acta Pol. Pharm. 70(6), 1087-96, (2013)

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Study on regulation of growth and biosynthesis of cellulolytic enzymes from newly isolated Aspergillus fumigatus ABK9. Das A, Paul T, Halder SK, et al. Pol. J. Microbiol. 62(1), 31-43, (2013)

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Formulation, in vitro drug release study and anticancer activity of 5-fluorouracil loaded gellan gum microbeads. Sahoo SK, Sahoo SK, Behera A, et al. Acta Pol. Pharm. 70(1), 123-7, (2013)

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Cellulose contents of some abundant Indian seaweed species. Siddhanta AK, Kumar S, Mehta GK, et al. Nat. Prod. Commun. 8(4), 497-500, (2013)

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The formulation of flurbiprofen loaded microspheres using hydroxypropylmethycellulose and ethylcellulose. Shahzad MK, Ubaid M, Raza M, et al. Adv. Clin. Exp. Med. 22(2), 177-83, (2013)

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Isolation and evaluation of native cellulose degrading microorganisms for efficient bioconversion of weed biomass and rice straw. Mahanta K, Jha DK, Rajkhowa DJ, et al. J. Environ Biol. 35(4), 721-5, (2014)

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Do bacterial cellulose membranes have potential in drug-delivery systems? Silvestre AJ, Freire CS, and Neto CP Expert Opin. Drug Deliv. 11(7), 1113-24, (2014)

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Removal of nitrite from aqueous solution using sugarcane bagasse and wheat straw. Diriba D, Hussen A, and Rao VM Bull. Environ. Contam. Toxicol. 93(1), 126-31, (2014)

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Molecular characterization of cellulose-degrading Bacillus pumilus from the soil of tea garden, Darjeeling hills, India. Padaria JC, Sarkar K, Lone SA, et al. J. Environ Biol. 35(3), 555-61, (2014)

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An investigation into the drug release from ibuprofen matrix tablets with ethylcellulose and some poly-acrylate polymers. Tabandeh H and Mortazavi SA Pak. J. Pharm. Sci. 27(3), 495-503, (2014)

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Layer-by-layer immobilized catalase on electrospun nanofibrous mats protects against oxidative stress induced by hydrogen peroxide. Huang R, Deng H, Cai T, et al. J. Biomed. Nanotechnol. 10(7), 1346-58, (2014)

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Effects of konjac glucomannan, inulin and cellulose on acute colonic responses to genotoxic azoxymethane. Wu WT, Yang LC, and Chen HL Food Chem. 155, 304-10, (2014)

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Description of Anaerobacterium chartisolvens gen. nov., sp. nov., an obligately anaerobic bacterium from Clostridium rRNA cluster III isolated from soil of a Japanese rice field, and reclassification of Bacteroides cellulosolvens Murray et al. 1984 as Pseudobacteroides cellulosolvens gen. nov., comb. nov. Horino H, Fujita T, and Tonouchi A Int. J. Syst. Evol. Microbiol. 64(Pt 4), 1296-303, (2014)

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Nanoparticle solutions as adhesives for gels and biological tissues. Rose S, Prevoteau A, Elzière P, et al. Nature 505(7483), 382-5, (2014)

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Surface structural dynamics of enzymatic cellulose degradation, revealed by combined kinetic and atomic force microscopy studies. Eibinger M, Bubner P, Ganner T, et al. FEBS J. 281(1), 275-90, (2014)

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Production and modification of nanofibrillated cellulose using various mechanical processes: a review. Abdul Khalil HP, Davoudpour Y, Islam MN, et al. Carbohydr. Polym. 99, 649-65, (2014)

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A Dictyostelium cellobiohydrolase orthologue that affects developmental timing. Kunii M, Yasuno M, Shindo Y, et al. Dev. Genes Evol. 224(1), 25-35, (2014)

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The ability of retention, drug release and rheological properties of nanogel bioadhesives based on cellulose derivatives. Keshavarz M and Kaffashi B Pharm. Dev. Technol. 19(8), 952-9, (2014)

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The impact of roller compaction and tablet compression on physicomechanical properties of pharmaceutical excipients. Iyer RM, Hegde S, Dinunzio J, et al. Pharm. Dev. Technol. 19(5), 583-92, (2014)

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A novel approach to determine solid fraction using a laser-based direct volume measurement device. Iyer RM, Hegde S, Singhal D, et al. Pharm. Dev. Technol. 19(5), 577-82, (2014)

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The fixation effect of a silk fibroin-bacterial cellulose composite plate in segmental defects of the zygomatic arch: an experimental study. Lee JM, Kim JH, Lee OJ, et al. JAMA Otolaryngol. Head Neck Surg. 139(6), 629-35, (2013)

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Merck 14,1965

RegBook 1 (2), 3159:J / Structure Index 1, 500:A:3 / Structure Index 1, 500:B:3

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