Ciprofloxacin

Papers

Modifying Culture Conditions In Chemical Library Screening Identifies Alternative Inhibitors Of Mycobacteria. Miller, C.H., et al. Antimicrob. Agents Chemother. 53, 5279-83, (2009)

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In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae. Arnold Louie, David L. Brown, et al. Antimicrob. Agents Chemother. 51, 3988-4000, (2007)

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Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines. N. Duewelhenke, O. Krut, et al. Antimicrob. Agents Chemother. 51, 54-63, (2007)

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Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. Wiles, J. A. et al. J. Med. Chem. 50, 199-210, (2007)

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Chiral DNA gyrase inhibitors. 3. Probing the chiral preference of the active site of DNA gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9-piperazinyl- 2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues. Robert A Fecik et al J. Med. Chem. 48, 1229-36, (2005)

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Cationic chalcone antibiotics. Design, synthesis, and mechanism of action. Simon F Nielsen et al J. Med. Chem. 48, 2667-77, (2005)

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Synthesis and antibacterial activity of 1-(2-fluorovinyl)-7-substituted-4-quinolone-3-carboxylic acid derivatives, conformationally restricted analogues of fleroxacin. Yoshikazu Asahina et al J. Med. Chem. 48, 3194-202, (2005)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. Noel J de Souza et al J. Med. Chem. 48, 5232-42, (2005)

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Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. Chengxin Zhi et al J. Med. Chem. 48, 7063-74, (2005)

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Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. Chang-Hsing Liang et al Bioorg. Med. Chem. Lett. 15, 2123-8, (2005)

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A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Motoi Tobita et al Bioorg. Med. Chem. Lett. 15, 2886-90, (2005)

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Identification of heteroarylenamines as a new class of antituberculosis lead molecules. Brent R Copp et al Bioorg. Med. Chem. Lett. 15, 4097-9, (2005)

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Antiviral 6-amino-quinolones: molecular basis for potency and selectivity. Sara N Richter et al Bioorg. Med. Chem. Lett. 15, 4247-51, (2005)

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Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. Alireza Foroumadi et al Bioorg. Med. Chem. Lett. 15, 4488-92, (2005)

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Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides. Irina O Zhuravel' et al Bioorg. Med. Chem. Lett. 15, 5483-7, (2005)

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Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. K W Ward et al Xenobiotica 35, 191-210, (2005)

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Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Larry J Jolivette et al J. Pharm. Pharm. Sci. 94, 1467-83, (2005)

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Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. Chengxin Zhi et al J. Med. Chem. 49, 1455-65, (2006)

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Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. Motohide Sato et al J. Med. Chem. 49, 1506-8, (2006)

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Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. Jason A Wiles et al J. Med. Chem. 49, 39-42, (2006)

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Novel antibacterial class: a series of tetracyclic derivatives. Mira M Hinman et al J. Med. Chem. 49, 4842-56, (2006)

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Antibacterial agent discovery using thymidylate synthase biolibrary screening. M Paola Costi et al J. Med. Chem. 49, 5958-68, (2006)

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3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. Edmund L Ellsworth et al J. Med. Chem. 49, 6435-8, (2006)

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Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. Annette Leon et al J. Med. Chem. 49, 7331-41, (2006)

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Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells. Jason A Wiles et al Bioorg. Med. Chem. Lett. 16, 1272-6, (2006)

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Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus. Jason A Wiles et al Bioorg. Med. Chem. Lett. 16, 1277-81, (2006)

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Design, synthesis, antibacterial, and QSAR studies of myristic acid derivatives. Balasubramanian Narasimhan et al Bioorg. Med. Chem. Lett. 16, 3023-9, (2006)

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Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. Alireza Foroumadi et al Bioorg. Med. Chem. Lett. 16, 3499-503, (2006)

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The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts. George P Nora et al Bioorg. Med. Chem. Lett. 16, 3966-70, (2006)

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Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents. Gaiying Zhao et al Bioorg. Med. Chem. Lett. 16, 5534-7, (2006)

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Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases. Karumanchi V Rao et al J. Nat. Prod. 69, 1034-40, (2006)

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Decaspirones F-I, bioactive secondary metabolites from the saprophytic fungus Helicoma viridis. Hejiao Hu et al J. Nat. Prod. 69, 1672-5, (2006)

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N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum. Lalith Jayasinghe et al J. Nat. Prod. 69, 439-42, (2006)

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Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens. Jin-Feng Hu et al J. Nat. Prod. 69, 585-90, (2006)

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5-alkylresorcinols from Merulius incarnatus. Wentao Jin et al J. Nat. Prod. 69, 704-6, (2006)

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An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Peng R Chen et al Nat. Chem. Biol. 2, 591-5, (2006)

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Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Sadanandan E Velu et al J. Med. Chem. 50, 2612-21, (2007)

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Novel semisynthetic derivative of antibiotic Eremomycin active against drug-resistant gram-positive pathogens including Bacillus anthracis. Kirk R Maples et al J. Med. Chem. 50, 3681-5, (2007)

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Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. Abbas Gholipour Shilabin et al J. Med. Chem. 50, 4340-50, (2007)

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Antimycobacterial activities of novel 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acid. Dharmarajan Sriram et al J. Med. Chem. 50, 6232-9, (2007)

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Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. Sergey A Shiryaev et al J. Biol. Chem. 282, 20847-53, (2007)

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Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors. Tuan P Tran et al Bioorg. Med. Chem. Lett. 17, 1312-20, (2007)

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Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones. Brijesh Kumar Srivastava et al Bioorg. Med. Chem. Lett. 17, 1924-9, (2007)

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Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase. Francesca Cateni et al Bioorg. Med. Chem. Lett. 17, 1971-8, (2007)

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The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents. Sean T Murphy et al Bioorg. Med. Chem. Lett. 17, 2150-5, (2007)

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Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. Ozden Ozel Güven et al Bioorg. Med. Chem. Lett. 17, 2233-6, (2007)

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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. John J M Wiener et al Bioorg. Med. Chem. Lett. 17, 2718-22, (2007)

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Synthesis and biological activity of enantiomeric pairs of 5-vinylthiolactomycin congeners. Kohei Ohata et al Bioorg. Med. Chem. Lett. 17, 4070-4, (2007)

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Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. V Tomar et al Bioorg. Med. Chem. Lett. 17, 5321-4, (2007)

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Quantitative structure-activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives. Balasubramanian Narasimhan et al Bioorg. Med. Chem. Lett. 17, 5836-45, (2007)

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New biologically active epidioxysterols from Stereum hirsutum. Francesca Cateni et al Bioorg. Med. Chem. Lett. 17, 6330-4, (2007)

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Synthesis and antibacterial activities of new quinolone derivatives utilizing 1-azabicyclo[1.1.0]butane. Yoshifumi Ikee et al Bioorg. Med. Chem. Lett. 17, 942-5, (2007)

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N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus. Kevin D Revell et al Bioorg. Med. Chem. 15, 2453-67, (2007)

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A new modification of anti-tubercular active molecules. Ales Imramovský et al Bioorg. Med. Chem. 15, 2551-9, (2007)

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Hybrid molecules of estrone: new compounds with potential antibacterial, antifungal, and antiproliferative activities. J Adamec et al Bioorg. Med. Chem. 15, 2898-906, (2007)

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Synthesis, antimicrobial, and QSAR studies of substituted benzamides. Anil Kumar et al Bioorg. Med. Chem. 15, 4113-24, (2007)

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Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives. Oya Bozdağ-Dündar et al Bioorg. Med. Chem. 15, 6012-7, (2007)

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Identification, biological activity, and mechanism of the anti-ischemic quinolone analog. Chan-Hee Park et al Bioorg. Med. Chem. 15, 6517-26, (2007)

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Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents. Xue Y Zhu et al Bioorg. Med. Chem. 15, 686-95, (2007)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Chemoenzymatic synthesis and antimicrobial activity evaluation of monoglucosyl diglycerides. Francesca Cateni et al Bioorg. Med. Chem. 15, 815-26, (2007)

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Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols. Sandip B Bharate et al Bioorg. Med. Chem. 15, 87-96, (2007)

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Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines. Kirandeep Kaur et al Bioorg. Med. Chem. 15, 915-30, (2007)

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Convenient one pot synthesis and antimicrobial evaluation of some new Mannich bases carrying 4-methylthiobenzyl moiety. Mithun Ashok et al Eur. J. Med. Chem. 42, 1095-101, (2007)

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Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. Betul Tekiner-Gulbas et al Eur. J. Med. Chem. 42, 1293-9, (2007)

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Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines. Mari Sithambaram Karthikeyan et al Eur. J. Med. Chem. 42, 30-6, (2007)

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Convenient one pot synthesis of some novel derivatives of thiazolo[2,3-b]dihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities. Mithun Ashok et al Eur. J. Med. Chem. 42, 380-5, (2007)

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Synthesis and antimicrobial activities of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines carrying thioalkyl and sulphonyl phenoxy moieties. T Karabasanagouda et al Eur. J. Med. Chem. 42, 521-9, (2007)

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Synthetic studies on novel benzimidazolopeptides with antimicrobial, cytotoxic and anthelmintic potential. Rajiv Dahiya et al Eur. J. Med. Chem. 42, 772-98, (2007)

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Synthesis, stereochemistry and antimicrobial evaluation of some N-morpholinoacetyl-2,6-diarylpiperidin-4-ones. G Aridoss et al Eur. J. Med. Chem. 42, 851-60, (2007)

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Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides. Farid El'Garch et al Antimicrob. Agents Chemother. 51, 1016-21, (2007)

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Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis. Juyan Zhou et al Antimicrob. Agents Chemother. 51, 1085-8, (2007)

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Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli. Manish Goswami et al Antimicrob. Agents Chemother. 51, 1119-22, (2007)

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Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Michelle M Butler et al Antimicrob. Agents Chemother. 51, 119-27, (2007)

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In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groups. Michael D Huband et al Antimicrob. Agents Chemother. 51, 1191-201, (2007)

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Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital. Jiunn-Jong Wu et al Antimicrob. Agents Chemother. 51, 1223-7, (2007)

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In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. Michael J Pucci et al Antimicrob. Agents Chemother. 51, 1259-67, (2007)

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Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. Anita Reinhardt et al Antimicrob. Agents Chemother. 51, 1341-50, (2007)

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Determination of antibiotic efficacy against Bacillus anthracis in a mouse aerosol challenge model. Henry S Heine et al Antimicrob. Agents Chemother. 51, 1373-9, (2007)

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Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Sang Hyun Cho et al Antimicrob. Agents Chemother. 51, 1380-5, (2007)

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rpoN gene of Pseudomonas aeruginosa alters its susceptibility to quinolones and carbapenems. Darija Viducic et al Antimicrob. Agents Chemother. 51, 1455-62, (2007)

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In vitro studies with DQ-113 and comparison fluoroquinolones to determine propensities to select resistance in gram-positive cocci. Seong Geun Hong et al Antimicrob. Agents Chemother. 51, 1512-4, (2007)

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Comparison of disk diffusion and agar dilution methods for erythromycin and ciprofloxacin susceptibility testing of Campylobacter jejuni subsp. jejuni. Christiane Gaudreau et al Antimicrob. Agents Chemother. 51, 1524-6, (2007)

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First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. Mariana Castanheira et al Antimicrob. Agents Chemother. 51, 1527-9, (2007)

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Fluoroquinolone resistance in Haemophilus influenzae is associated with hypermutability. María Pérez-Vázquez et al Antimicrob. Agents Chemother. 51, 1566-9, (2007)

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In vitro activities of various antimicrobials alone and in combination with tigecycline against carbapenem-intermediate or -resistant Acinetobacter baumannii. Marc H Scheetz et al Antimicrob. Agents Chemother. 51, 1621-6, (2007)

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Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones. Stéphanie Matrat et al Antimicrob. Agents Chemother. 51, 1643-8, (2007)

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Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Eliane Garo et al Antimicrob. Agents Chemother. 51, 1813-7, (2007)

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Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. Nuno Mendonça et al Antimicrob. Agents Chemother. 51, 1946-55, (2007)

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Effects of carbapenem exposure on the risk for digestive tract carriage of intensive care unit-endemic carbapenem-resistant Pseudomonas aeruginosa strains in critically ill patients. C Peña et al Antimicrob. Agents Chemother. 51, 1967-71, (2007)

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Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Mario Tumbarello et al Antimicrob. Agents Chemother. 51, 1987-94, (2007)

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Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii. Anton Y Peleg et al Antimicrob. Agents Chemother. 51, 2065-9, (2007)

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Polyamine effects on antibiotic susceptibility in bacteria. Dong-Hyeon Kwon et al Antimicrob. Agents Chemother. 51, 2070-7, (2007)

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Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase. Andrea Endimiani et al Antimicrob. Agents Chemother. 51, 2211-4, (2007)

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Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1. J M Rodríguez-Martínez et al Antimicrob. Agents Chemother. 51, 2236-9, (2007)

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Enterobacteriaceae bloodstream infections: presence of integrons, risk factors, and outcome. George L Daikos et al Antimicrob. Agents Chemother. 51, 2366-72, (2007)

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Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. Jijun Cheng et al Antimicrob. Agents Chemother. 51, 2445-53, (2007)

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Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Bruno Périchon et al Antimicrob. Agents Chemother. 51, 2464-9, (2007)

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Influence of high mutation rates on the mechanisms and dynamics of in vitro and in vivo resistance development to single or combined antipseudomonal agents. V Plasencia et al Antimicrob. Agents Chemother. 51, 2574-81, (2007)

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Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 51, 2611-4, (2007)

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Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model. Matthew E Griffith et al Antimicrob. Agents Chemother. 51, 2615-7, (2007)

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blaVIM-2-harboring integrons isolated in India, Russia, and the United States arise from an ancestral class 1 integron predating the formation of the 3' conserved sequence. Mark A Toleman et al Antimicrob. Agents Chemother. 51, 2636-8, (2007)

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Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. Vincent Cattoir et al Antimicrob. Agents Chemother. 51, 2650-1, (2007)

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Plasmid-mediated quinolone resistance determinant QnrB4 identified in France in an Enterobacter cloacae clinical isolate coexpressing a QnrS1 determinant. Vincent Cattoir et al Antimicrob. Agents Chemother. 51, 2652-3, (2007)

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Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. Daniel A Adams et al Antimicrob. Agents Chemother. 51, 2674-8, (2007)

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Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. Michael Meehl et al Antimicrob. Agents Chemother. 51, 2679-89, (2007)

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Fluoroquinolone resistance in atypical pneumococci and oral streptococci: evidence of horizontal gene transfer of fluoroquinolone resistance determinants from Streptococcus pneumoniae. Margaret Ip et al Antimicrob. Agents Chemother. 51, 2690-700, (2007)

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Rapid dissemination and diversity of CTX-M extended-spectrum beta-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America. Lucia Pallecchi et al Antimicrob. Agents Chemother. 51, 2720-5, (2007)

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Effect of anaerobic growth on quinolone lethality with Escherichia coli. Muhammad Malik et al Antimicrob. Agents Chemother. 51, 28-34, (2007)

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Rifaximin does not induce toxin production or phage-mediated lysis of Shiga toxin-producing Escherichia coli. Theresa J Ochoa et al Antimicrob. Agents Chemother. 51, 2837-41, (2007)

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Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. Marie-Frédérique Lartigue et al Antimicrob. Agents Chemother. 51, 2855-60, (2007)

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Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005. Jacob Strahilevitz et al Antimicrob. Agents Chemother. 51, 3001-3, (2007)

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Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. Ying-Tsong Chen et al Antimicrob. Agents Chemother. 51, 3004-7, (2007)

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Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Azita Leavitt et al Antimicrob. Agents Chemother. 51, 3026-9, (2007)

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First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. Alexandros Ikonomidis et al Antimicrob. Agents Chemother. 51, 3038-9, (2007)

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In vitro activities of different inhibitors of bacterial transcription against Staphylococcus epidermidis biofilm. Philippe Villain-Guillot et al Antimicrob. Agents Chemother. 51, 3117-21, (2007)

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Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. Astrid Pérez et al Antimicrob. Agents Chemother. 51, 3247-53, (2007)

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Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones. Stéphanie Arsène et al Antimicrob. Agents Chemother. 51, 3254-8, (2007)

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New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Kunikazu Yamane et al Antimicrob. Agents Chemother. 51, 3354-60, (2007)

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In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. W T M Jansen et al Antimicrob. Agents Chemother. 51, 3420-4, (2007)

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Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model. Lisa A Kroeger et al Antimicrob. Agents Chemother. 51, 3431-3, (2007)

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In vitro susceptibilities of Mycoplasma putrefaciens field isolates. N T Antunes et al Antimicrob. Agents Chemother. 51, 3452-4, (2007)

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Quinolone resistance in Helicobacter pylori isolates in Germany. Erik Glocker et al Antimicrob. Agents Chemother. 51, 346-9, (2007)

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Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Erica L Dahl et al Antimicrob. Agents Chemother. 51, 3485-90, (2007)

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Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. Didier Hocquet et al Antimicrob. Agents Chemother. 51, 3531-6, (2007)

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Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae. Hyunjoo Pai et al Antimicrob. Agents Chemother. 51, 366-8, (2007)

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Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening. David A Ostrov et al Antimicrob. Agents Chemother. 51, 3688-98, (2007)

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An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. Wensi S Hu et al Antimicrob. Agents Chemother. 51, 3844-52, (2007)

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Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Andrew E Simor et al Antimicrob. Agents Chemother. 51, 3880-6, (2007)

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Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Hui Wang et al Antimicrob. Agents Chemother. 51, 4022-8, (2007)

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Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1. Xiaogang Xu et al Antimicrob. Agents Chemother. 51, 4105-10, (2007)

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Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae. Daniel E Rozen et al Antimicrob. Agents Chemother. 51, 412-6, (2007)

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Clinical prediction tool to identify patients with Pseudomonas aeruginosa respiratory tract infections at greatest risk for multidrug resistance. Thomas P Lodise et al Antimicrob. Agents Chemother. 51, 417-22, (2007)

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Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-beta-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005. Jerneja Ambrozic Avgustin et al Antimicrob. Agents Chemother. 51, 4171-3, (2007)

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Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Sonia K Morgan-Linnell et al Antimicrob. Agents Chemother. 51, 4205-8, (2007)

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Treatment and outcomes of infections by methicillin-resistant Staphylococcus aureus at an ambulatory clinic. John D Szumowski et al Antimicrob. Agents Chemother. 51, 423-8, (2007)

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Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells. Carmela T M Mascio et al Antimicrob. Agents Chemother. 51, 4255-60, (2007)

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Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. Michelle D Brazas et al Antimicrob. Agents Chemother. 51, 4276-83, (2007)

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Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Tran Thuy Chau et al Antimicrob. Agents Chemother. 51, 4315-23, (2007)

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Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. O Gutiérrez et al Antimicrob. Agents Chemother. 51, 4329-35, (2007)

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Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. María Paula Quiroga et al Antimicrob. Agents Chemother. 51, 4466-70, (2007)

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Antimicrobial susceptibilities and clinical sources of Dialister species. F Morio et al Antimicrob. Agents Chemother. 51, 4498-501, (2007)

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Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials. Sheng Chen et al Antimicrob. Agents Chemother. 51, 535-42, (2007)

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Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy. Radha K Shandil et al Antimicrob. Agents Chemother. 51, 576-82, (2007)

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Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. Trudy H Grossman et al Antimicrob. Agents Chemother. 51, 657-66, (2007)

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Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. Ze-Qing Wei et al Antimicrob. Agents Chemother. 51, 763-5, (2007)

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First characterization of fluoroquinolone resistance in Streptococcus suis. Jose Antonio Escudero et al Antimicrob. Agents Chemother. 51, 777-82, (2007)

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In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa. Shinobu Takeda et al Antimicrob. Agents Chemother. 51, 826-30, (2007)

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Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus. Céline Vidaillac et al Antimicrob. Agents Chemother. 51, 831-8, (2007)

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Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil. Yohei Doi et al Antimicrob. Agents Chemother. 51, 852-6, (2007)

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Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Christopher A Elkins et al Antimicrob. Agents Chemother. 51, 923-9, (2007)

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Bioactive p-terphenyl derivatives from a Cordyceps-colonizing isolate of Gliocladium sp. Huijuan Guo et al J. Nat. Prod. 70, 1519-21, (2007)

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Epicoccins A-D, epipolythiodioxopiperazines from a Cordyceps-colonizing isolate of Epicoccum nigrum. Yonggang Zhang et al J. Nat. Prod. 70, 1522-5, (2007)

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Unusual naphthoquinone derivatives from the twigs of Avicennia marina. Li Han et al J. Nat. Prod. 70, 923-7, (2007)

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Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent. Yoshikazu Asahina et al J. Med. Chem. 51, 3238-49, (2008)

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From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump. Stefano Sabatini et al J. Med. Chem. 51, 4321-30, (2008)

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Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological intervention. Raju Ranjith Kumar et al J. Med. Chem. 51, 5731-5, (2008)

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Linking bisphosphonates to the free amino groups in fluoroquinolones: preparation of osteotropic prodrugs for the prevention of osteomyelitis. Tom J Houghton et al J. Med. Chem. 51, 6955-69, (2008)

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Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors. Yuefen Zhou et al Bioorg. Med. Chem. Lett. 18, 3369-75, (2008)

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Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment. Santosh D Diwakar et al Bioorg. Med. Chem. Lett. 18, 4678-81, (2008)

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Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones. Kim M Hutchings et al Bioorg. Med. Chem. Lett. 18, 5087-90, (2008)

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Synthesis and biological activity of enantiomeric pairs of 5-[(E)-cycloalk-2-enylidenemethyl]thiolactomycin congeners. Kohei Ohata et al Bioorg. Med. Chem. Lett. 18, 5598-600, (2008)

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S-Euglobals: biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities. Sandip B Bharate et al Bioorg. Med. Chem. 16, 1328-36, (2008)

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Support vector machines classification of hERG liabilities based on atom types. Lei Jia et al Bioorg. Med. Chem. 16, 6252-60, (2008)

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Citral derived amides as potent bacterial NorA efflux pump inhibitors. Niranjan Thota et al Bioorg. Med. Chem. 16, 6535-43, (2008)

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2-N-Methyl modifications and SAR studies of manzamine A. Mohamed A Ibrahim et al Bioorg. Med. Chem. 16, 6702-6, (2008)

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Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives. Bruno Leal et al Bioorg. Med. Chem. 16, 8196-204, (2008)

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Bisphosphonated fluoroquinolone esters as osteotropic prodrugs for the prevention of osteomyelitis. Kelly S E Tanaka et al Bioorg. Med. Chem. 16, 9217-29, (2008)

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Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors. P. L. Sangwan, et al., Bioorg. Med. Chem. 16, 9847-9857, (2008)

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Synthesis and antibacterial activity of bis-[2-hydroxy-3-(1,7,8,9,10-pentamethyl-3,5-dioxo-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-en-4-yloxy)-propyl]-dimethyl-ammonium chloride. Marta Struga et al Eur. J. Med. Chem. 43, 1309-14, (2008)

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Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. S D Joshi et al Eur. J. Med. Chem. 43, 1989-96, (2008)

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DNA binding and biological studies of some novel water-soluble polymer-copper(II)-phenanthroline complexes. Rajendran Senthil Kumar et al Eur. J. Med. Chem. 43, 2082-91, (2008)

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Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides. Francesca Cateni et al Eur. J. Med. Chem. 43, 210-21, (2008)

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Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps. Nadezhda German et al Eur. J. Med. Chem. 43, 2453-63, (2008)

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Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles. Mari Sithambaram Karthikeyan et al Eur. J. Med. Chem. 43, 25-31, (2008)

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Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents. Prakash Karegoudar et al Eur. J. Med. Chem. 43, 261-7, (2008)

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Synthesis and antimicrobial studies of novel dichlorofluorophenyl containing aminotriazolothiadiazines. Mari Sithambaram Karthikeyan et al Eur. J. Med. Chem. 43, 309-14, (2008)

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Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives--an extended structure-activity relationship study. Siavosh Mahboobi et al Eur. J. Med. Chem. 43, 633-56, (2008)

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Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety. Prakash Karegoudar et al Eur. J. Med. Chem. 43, 808-15, (2008)

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Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. Didier Hocquet et al Antimicrob. Agents Chemother. 52, 1173-5, (2008)

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Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil. David Sevillano et al Antimicrob. Agents Chemother. 52, 1184-6, (2008)

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Fluoroquinolone-resistant mutants of Burkholderia cepacia. C F Pope et al Antimicrob. Agents Chemother. 52, 1201-3, (2008)

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Escherichia coli isolate coproducing 16S rRNA Methylase and CTX-M-type extended-spectrum beta-lactamase isolated from an outpatient in the United States. Yohei Doi et al Antimicrob. Agents Chemother. 52, 1204-5, (2008)

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Novel variant of the qnrB gene, qnrB12, in Citrobacter werkmanii. Corinna Kehrenberg et al Antimicrob. Agents Chemother. 52, 1206-7, (2008)

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DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties. Saeed M Hashimi et al Antimicrob. Agents Chemother. 52, 1382-90, (2008)

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Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. George G Zhanel et al Antimicrob. Agents Chemother. 52, 1430-7, (2008)

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Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo. Anne J Lenaerts et al Antimicrob. Agents Chemother. 52, 1513-5, (2008)

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Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. Kunikazu Yamane et al Antimicrob. Agents Chemother. 52, 1564-6, (2008)

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Effect of polysorbate 80 on oritavancin binding to plastic surfaces: implications for susceptibility testing. Francis F Arhin et al Antimicrob. Agents Chemother. 52, 1597-603, (2008)

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Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. Hayssam Khalil et al Antimicrob. Agents Chemother. 52, 1635-41, (2008)

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Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. S Grayo et al Antimicrob. Agents Chemother. 52, 1697-702, (2008)

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Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. Doroti de Oliveira Garcia et al Antimicrob. Agents Chemother. 52, 1790-3, (2008)

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The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. Nuno Mendonça et al Antimicrob. Agents Chemother. 52, 1806-11, (2008)

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Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. Patricia J Baudry et al Antimicrob. Agents Chemother. 52, 1846-9, (2008)

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Emergence of fluoroquinolone resistance in group B streptococcal isolates in Taiwan. Hsiu-Mei Wu et al Antimicrob. Agents Chemother. 52, 1888-90, (2008)

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Enrichment of fluoroquinolone-resistant Staphylococcus aureus: oscillating ciprofloxacin concentrations simulated at the upper and lower portions of the mutant selection window. Alexander A Firsov et al Antimicrob. Agents Chemother. 52, 1924-8, (2008)

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Delayed development of linezolid resistance in Staphylococcus aureus following exposure to low levels of antimicrobial agents. Keith Miller et al Antimicrob. Agents Chemother. 52, 1940-4, (2008)

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Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. Jia Chang Cai et al Antimicrob. Agents Chemother. 52, 2014-8, (2008)

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Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. Elena N Ilina et al Antimicrob. Agents Chemother. 52, 2175-82, (2008)

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The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. Silke Besier et al Antimicrob. Agents Chemother. 52, 2183-9, (2008)

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Daptomycin exerts bactericidal activity without lysis of Staphylococcus aureus. Nicole Cotroneo et al Antimicrob. Agents Chemother. 52, 2223-5, (2008)

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First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 52, 2244-6, (2008)

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In vitro susceptibility of isolates of Francisella tularensis types A and B from North America. Sandra K Urich et al Antimicrob. Agents Chemother. 52, 2276-8, (2008)

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Antistreptococcal activity of AR-709 compared to that of other agents. Kathy Smith et al Antimicrob. Agents Chemother. 52, 2279-82, (2008)

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IMP-15-producing Pseudomonas aeruginosa strain isolated in a U.S. medical center: a recent arrival from Mexico. Craig A Martin et al Antimicrob. Agents Chemother. 52, 2289-90, (2008)

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In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus. Gregory T Robertson et al Antimicrob. Agents Chemother. 52, 2313-23, (2008)

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ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Yousef M Abouzeed et al Antimicrob. Agents Chemother. 52, 2428-34, (2008)

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Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. Katy Jeannot et al Antimicrob. Agents Chemother. 52, 2455-62, (2008)

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Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. A Louie et al Antimicrob. Agents Chemother. 52, 2486-96, (2008)

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In vitro activity of telavancin against resistant gram-positive bacteria. Kevin M Krause et al Antimicrob. Agents Chemother. 52, 2647-52, (2008)

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In vitro activities of tigecycline against clinical isolates of Aeromonas, Vibrio, and Salmonella species in Taiwan. Chia-Ying Liu et al Antimicrob. Agents Chemother. 52, 2677-9, (2008)

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Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. Andrea Endimiani et al Antimicrob. Agents Chemother. 52, 2680-2, (2008)

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Role of Cj1211 in natural transformation and transfer of antibiotic resistance determinants in Campylobacter jejuni. Byeonghwa Jeon et al Antimicrob. Agents Chemother. 52, 2699-708, (2008)

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Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Sonja Hansen et al Antimicrob. Agents Chemother. 52, 2718-26, (2008)

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Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2. Maria Pränting et al Antimicrob. Agents Chemother. 52, 2734-41, (2008)

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Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. Roseanne A Ressner et al Antimicrob. Agents Chemother. 52, 2750-4, (2008)

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Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Alita A Miller et al Antimicrob. Agents Chemother. 52, 2806-12, (2008)

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Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. Pattarachai Kiratisin et al Antimicrob. Agents Chemother. 52, 2818-24, (2008)

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ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 2929-32, (2008)

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Metallo-beta-lactamase gene bla(IMP-15) in a class 1 integron, In95, from Pseudomonas aeruginosa clinical isolates from a hospital in Mexico. U Garza-Ramos et al Antimicrob. Agents Chemother. 52, 2943-6, (2008)

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Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Amélie Carrër et al Antimicrob. Agents Chemother. 52, 2950-4, (2008)

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Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate. Sara Marti et al Antimicrob. Agents Chemother. 52, 2955-8, (2008)

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Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates. Inna Chmelnitsky et al Antimicrob. Agents Chemother. 52, 2962-5, (2008)

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Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China. Yingmei Fu et al Antimicrob. Agents Chemother. 52, 2980-3, (2008)

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bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. Björn A Espedido et al Antimicrob. Agents Chemother. 52, 2984-7, (2008)

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Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate. Javier Sánchez-Céspedes et al Antimicrob. Agents Chemother. 52, 2990-1, (2008)

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Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. Jian-Hua Liu et al Antimicrob. Agents Chemother. 52, 2992-3, (2008)

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Emergence of the plasmid-mediated quinolone resistance gene qnrS1 in Escherichia coli isolates in Greece. Olga Vasilaki et al Antimicrob. Agents Chemother. 52, 2996-7, (2008)

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Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Feng Long et al Antimicrob. Agents Chemother. 52, 3052-60, (2008)

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Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. Annie-Claude Labbé et al Antimicrob. Agents Chemother. 52, 3180-7, (2008)

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Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. Mario Tumbarello et al Antimicrob. Agents Chemother. 52, 3244-52, (2008)

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Activity of meropenem with and without ciprofloxacin and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii. Glenn A Pankuch et al Antimicrob. Agents Chemother. 52, 333-6, (2008)

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Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax. H S Heine et al Antimicrob. Agents Chemother. 52, 3350-7, (2008)

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In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. Karen M Amsler et al Antimicrob. Agents Chemother. 52, 3418-23, (2008)

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The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae. Louis B Rice et al Antimicrob. Agents Chemother. 52, 3427-9, (2008)

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Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain. Carlos Juan et al Antimicrob. Agents Chemother. 52, 3589-96, (2008)

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RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. Andrew M Bailey et al Antimicrob. Agents Chemother. 52, 3604-11, (2008)

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Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas. Ken B Waites et al Antimicrob. Agents Chemother. 52, 3776-8, (2008)

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Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation. Koichi Tanimoto et al Antimicrob. Agents Chemother. 52, 3795-800, (2008)

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Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 3801-4, (2008)

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Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. Kenichiro Shimizu et al Antimicrob. Agents Chemother. 52, 3823-5, (2008)

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Antimicrobial studies with the Pseudomonas aeruginosa two-allele library require caution. Xiangli Wu et al Antimicrob. Agents Chemother. 52, 3826-7, (2008)

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Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania. Jennifer M Adams-Haduch et al Antimicrob. Agents Chemother. 52, 3837-43, (2008)

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Use of gyrase resistance mutants to guide selection of 8-methoxy-quinazoline-2,4-diones. Nadezhda German et al Antimicrob. Agents Chemother. 52, 3915-21, (2008)

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Is 60 days of ciprofloxacin administration necessary for postexposure prophylaxis for Bacillus anthracis? G L Drusano et al Antimicrob. Agents Chemother. 52, 3973-9, (2008)

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First countrywide survey of acquired metallo-beta-lactamases in gram-negative pathogens in Italy. Gian Maria Rossolini et al Antimicrob. Agents Chemother. 52, 4023-9, (2008)

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A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital. Raffaele Zarrilli et al Antimicrob. Agents Chemother. 52, 4115-20, (2008)

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Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. S Page et al Antimicrob. Agents Chemother. 52, 4155-8, (2008)

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Plasmid-mediated quinolone resistance determinants qnrA, qnrB, and qnrS among clinical isolates of Enterobacteriaceae in a Korean hospital. Migma Dorji Tamang et al Antimicrob. Agents Chemother. 52, 4159-62, (2008)

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Thiopurine drugs azathioprine and 6-mercaptopurine inhibit Mycobacterium paratuberculosis growth in vitro. Sung Jae Shin et al Antimicrob. Agents Chemother. 52, 418-26, (2008)

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In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria. R Fernández-Roblas et al Antimicrob. Agents Chemother. 52, 4184-6, (2008)

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Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of Streptococcus pyogenes. Christoph B Duesberg et al Antimicrob. Agents Chemother. 52, 4191-3, (2008)

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Carbapenem-resistant Acinetobacter baumannii isolates expressing the blaOXA-23 gene associated with ISAba4 in Belgium. Pierre Bogaerts et al Antimicrob. Agents Chemother. 52, 4205-6, (2008)

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High prevalence of plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. Hong Yang et al Antimicrob. Agents Chemother. 52, 4268-73, (2008)

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Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Sreedhar Subramanian et al Antimicrob. Agents Chemother. 52, 427-34, (2008)

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Inhibition of Bacillus anthracis spore outgrowth by nisin. Ian M Gut et al Antimicrob. Agents Chemother. 52, 4281-8, (2008)

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Comparison of disk diffusion and agar dilution methods for erythromycin, ciprofloxacin, and tetracycline susceptibility testing of Campylobacter coli and for tetracycline susceptibility testing of Campylobacter jejuni subsp. jejuni. Christiane Gaudreau et al Antimicrob. Agents Chemother. 52, 4475-7, (2008)

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Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility. Elena B M Breidenstein et al Antimicrob. Agents Chemother. 52, 4486-91, (2008)

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Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. Béatrice Berçot et al Antimicrob. Agents Chemother. 52, 4526-7, (2008)

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Antimicrobial activities of tigecycline and other broad-spectrum antimicrobials tested against serine carbapenemase- and metallo-beta-lactamase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program. Mariana Castanheira et al Antimicrob. Agents Chemother. 52, 570-3, (2008)

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In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. Catherine Clark et al Antimicrob. Agents Chemother. 52, 77-84, (2008)

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RmtC 16S rRNA methyltransferase in Australia. Zhiyong Zong et al Antimicrob. Agents Chemother. 52, 794-5, (2008)

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Fitness of Streptococcus pneumoniae fluoroquinolone-resistant strains with topoisomerase IV recombinant genes. Luz Balsalobre et al Antimicrob. Agents Chemother. 52, 822-30, (2008)

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Reduced Susceptibility of Proteus mirabilis to triclosan. David J Stickler et al Antimicrob. Agents Chemother. 52, 991-4, (2008)

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Kinetic studies and bioactivity of potential manzamine prodrugs. Abbas Gholipour Shilabin et al J. Nat. Prod. 71, 1218-21, (2008)

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Bioactive brominated metabolites from the red sea sponge Suberea mollis. Mohamed I Abou-Shoer et al J. Nat. Prod. 71, 1464-7, (2008)

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Sorocenols G and H, anti-MRSA oxygen heterocyclic Diels-Alder-type adducts from Sorocea muriculata roots. Samir A Ross et al J. Nat. Prod. 71, 1764-7, (2008)

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Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits. Karel Smejkal et al J. Nat. Prod. 71, 706-9, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics. Varvara Pokrovskaya et al J. Med. Chem. 52, 2243-54, (2009)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Design, synthesis, and structure-activity relationships of benzophenone-based tetraamides as novel antibacterial agents. Sunil K Vooturi et al J. Med. Chem. 52, 5020-31, (2009)

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Discovery of Trp-His and His-Arg analogues as new structural classes of short antimicrobial peptides. Rohit K Sharma et al J. Med. Chem. 52, 7421-31, (2009)

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Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach. Faustine Dubar et al J. Med. Chem. 52, 7954-7, (2009)

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5-Nitrofuran-2-yl derivatives: synthesis and inhibitory activities against growing and dormant mycobacterium species. Dharmarajan Sriram et al Bioorg. Med. Chem. Lett. 19, 1152-4, (2009)

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Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents. Laixing Hu et al Bioorg. Med. Chem. Lett. 19, 1292-5, (2009)

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Synthesis of citrate-ciprofloxacin conjugates. Siti R Md-Saleh et al Bioorg. Med. Chem. Lett. 19, 1496-8, (2009)

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Synthesis, antimicrobial activity and QSAR studies of new 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazoles. Maninder Minu et al Bioorg. Med. Chem. Lett. 19, 2960-4, (2009)

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Synthesis, spectral, crystal and antimicrobial studies of biologically potent oxime ethers of nitrogen, oxygen and sulfur heterocycles. Paramasivam Parthiban et al Bioorg. Med. Chem. Lett. 19, 2981-5, (2009)

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Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents. Laixing Hu et al Bioorg. Med. Chem. Lett. 19, 3374-7, (2009)

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Regioselective synthesis and biological evaluation of bis(indolyl)methane derivatized 1,4-disubstituted 1,2,3-bistriazoles as anti-infective agents. M Damodiran et al Bioorg. Med. Chem. Lett. 19, 3611-4, (2009)

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The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents. Xiaoguang Huang et al Bioorg. Med. Chem. Lett. 19, 4130-3, (2009)

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Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents. Laixing Hu et al Bioorg. Med. Chem. Lett. 19, 4626-9, (2009)

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Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones. Bin Zhu et al Bioorg. Med. Chem. Lett. 19, 4933-6, (2009)

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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Lloyd G Czaplewski et al Bioorg. Med. Chem. Lett. 19, 524-7, (2009)

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Arginine-pyrimidine conjugates with therapeutic and prophylactic activity in lethal bacterial infections. Dieter Haebich et al Bioorg. Med. Chem. Lett. 19, 6317-8, (2009)

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Synthesis, stereochemistry and antimicrobial studies of novel oxime ethers of aza/diazabicycles. Paramasivam Parthiban et al Bioorg. Med. Chem. Lett. 19, 6981-5, (2009)

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Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones. Xiang Ma et al Bioorg. Med. Chem. Lett. 19, 986-9, (2009)

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Synthesis and antimicrobial evaluation of some new substituted purine derivatives. Meral Tunçbilek et al Bioorg. Med. Chem. 17, 1693-700, (2009)

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Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Constance Chollet et al Bioorg. Med. Chem. 17, 2512-23, (2009)

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Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide. el-Shimaa M N Abdel-Hafez et al Bioorg. Med. Chem. 17, 3829-37, (2009)

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7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. Joëlle Azéma et al Bioorg. Med. Chem. 17, 5396-407, (2009)

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Interaction of drug based binuclear mixed-ligand complexes with DNA. Mohan N Patel et al Bioorg. Med. Chem. 17, 5648-55, (2009)

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Synthesis and antibacterial property of quinolines with potent DNA gyrase activity. Ekambaram Ramesh et al Bioorg. Med. Chem. 17, 660-6, (2009)

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Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Rie Miyauchi et al Bioorg. Med. Chem. 17, 6879-89, (2009)

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Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety. Amir E Wahba et al Bioorg. Med. Chem. 17, 7775-82, (2009)

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Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers. Desmond Slade et al Bioorg. Med. Chem. 17, 7949-57, (2009)

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Synthesis and in vitro antimicrobial activity of some novel substituted benzimidazole derivatives having potent activity against MRSA. Meral Tunçbilek et al Eur. J. Med. Chem. 44, 1024-33, (2009)

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Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. Deepika Sharma et al Eur. J. Med. Chem. 44, 1119-27, (2009)

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Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings. Sarvesh Kumar Pandey et al Eur. J. Med. Chem. 44, 1188-97, (2009)

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Synthesis of new 2-substituted pyrido[2,3-d]pyrimidin-4(1H)-ones and their antibacterial activity. B Lakshmi Narayana et al Eur. J. Med. Chem. 44, 1369-76, (2009)

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New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines. A B A el-Gazzar et al Eur. J. Med. Chem. 44, 1427-36, (2009)

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Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides. G Venkat Reddy et al Eur. J. Med. Chem. 44, 1570-8, (2009)

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Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives. Afshin Fassihi et al Eur. J. Med. Chem. 44, 2145-57, (2009)

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Fullerene derivatized s-triazine analogues as antimicrobial agents. Anish Kumar et al Eur. J. Med. Chem. 44, 2178-83, (2009)

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Quantitative structure-activity relationship (QSAR) of aryl alkenyl amides/imines for bacterial efflux pump inhibitors. A Nargotra et al Eur. J. Med. Chem. 44, 229-38, (2009)

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Synthesis and bioassay of a new class of heterocycles pyrrolyl oxadiazoles/thiadiazoles/triazoles. V Padmavathi et al Eur. J. Med. Chem. 44, 2313-21, (2009)

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Synthesis and anti-microbial screening of some Schiff bases of 3-amino-6,8-dibromo-2-phenylquinazolin-4(3H)-ones. Perumal Panneerselvam et al Eur. J. Med. Chem. 44, 2328-33, (2009)

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Regioselective synthetic approaches towards 1,2,8,9-tetraazadispiro[4.1.4.2]trideca-2,9-dien-6-ones of potential antimicrobial properties. Adel S Girgis et al Eur. J. Med. Chem. 44, 2447-51, (2009)

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Synthesis and evaluation of antibacterial activities of andrographolide analogues. Xiaojian Jiang et al Eur. J. Med. Chem. 44, 2936-43, (2009)

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Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation. Tilak Raj et al Eur. J. Med. Chem. 44, 3209-16, (2009)

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Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation. R Venkat Ragavan et al Eur. J. Med. Chem. 44, 3852-7, (2009)

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Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives. K F Ansari et al Eur. J. Med. Chem. 44, 4028-33, (2009)

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Quantitative structure activity relationship (QSAR) of piperine analogs for bacterial NorA efflux pump inhibitors. Amit Nargotra et al Eur. J. Med. Chem. 44, 4128-35, (2009)

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Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones. G Aridoss et al Eur. J. Med. Chem. 44, 4199-210, (2009)

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Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles. Ramya V Shingalapur et al Eur. J. Med. Chem. 44, 4244-8, (2009)

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Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant--gossypol. P. Przybylski, et al., Eur. J. Med. Chem. 44, 4393-4403, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1,2,4-triazole moiety. Sumesh Eswaran et al Eur. J. Med. Chem. 44, 4637-47, (2009)

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Antioxidant and antibacterial studies of arylazopyrazoles and arylhydrazonopyrazolones containing coumarin moiety. P Manojkumar et al Eur. J. Med. Chem. 44, 4690-4, (2009)

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Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. B P Mallikarjuna et al Eur. J. Med. Chem. 44, 4739-46, (2009)

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Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines. Tanaji N Bansode et al Eur. J. Med. Chem. 44, 5094-8, (2009)

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Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide. Vikrant S Palekar et al Eur. J. Med. Chem. 44, 5112-6, (2009)

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2-Azetidinone derivatives: design, synthesis, in vitro anti-microbial, cytotoxic activities and DNA cleavage study. Rangappa S Keri et al Eur. J. Med. Chem. 44, 5123-30, (2009)

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Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety. D Jagadeesh Prasad et al Eur. J. Med. Chem. 44, 551-7, (2009)

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Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: antimicrobial, analgesic and antipyretic studies. G Aridoss et al Eur. J. Med. Chem. 44, 577-92, (2009)

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Hansch analysis of veratric acid derivatives as antimicrobial agents. Balasubramanian Narasimhan et al Eur. J. Med. Chem. 44, 689-700, (2009)

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Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles. Mari Sithambaram Karthikeyan et al Eur. J. Med. Chem. 44, 827-33, (2009)

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Synthesis of novel benzo[h]quinolines: wound healing, antibacterial, DNA binding and in vitro antioxidant activity. Halehatty R Prakash Naik et al Eur. J. Med. Chem. 44, 981-9, (2009)

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Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum beta-lactamases. Ling Ma et al Antimicrob. Agents Chemother. 53, 104-11, (2009)

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Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators. Edel O'Regan et al Antimicrob. Agents Chemother. 53, 1080-7, (2009)

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Theileria apicoplast as a target for chemotherapy. Regina Lizundia et al Antimicrob. Agents Chemother. 53, 1213-7, (2009)

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Antimicrobial Activity of Prulifloxacin Tested against a Worldwide Collection of Gastroenteritis-Producing Pathogens, Including Those Causing Traveler's Diarrhea Fritsche, T. R.; Biedenbach, D. J., et al. Antimicrob. Agents Chemother. 53, 1221-1224, (2008)

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Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). Mariana Castanheira et al Antimicrob. Agents Chemother. 53, 1225-7, (2009)

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Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. Longzhu Cui et al Antimicrob. Agents Chemother. 53, 1231-4, (2009)

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Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 53, 1260-3, (2009)

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Quinolone resistance in Neisseria gonorrhoeae: rapid genotyping of quinolone resistance-determining regions in gyrA and parC genes by melting curve analysis predicts susceptibility. Frédérique Vernel-Pauillac et al Antimicrob. Agents Chemother. 53, 1264-7, (2009)

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Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. Vidhya Prakash et al Antimicrob. Agents Chemother. 53, 1278-80, (2009)

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Prevalence and risk factors for selection of quinolone-resistant Escherichia coli strains in fecal flora of patients receiving quinolone therapy. D Yagci et al Antimicrob. Agents Chemother. 53, 1287-9, (2009)

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Contribution of oxidative damage to antimicrobial lethality. Xiuhong Wang et al Antimicrob. Agents Chemother. 53, 1395-402, (2009)

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Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. Xavier Mulet et al Antimicrob. Agents Chemother. 53, 1552-60, (2009)

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Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. Sara Thulin Hedberg et al Antimicrob. Agents Chemother. 53, 1561-6, (2009)

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blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. Elzbieta Literacka et al Antimicrob. Agents Chemother. 53, 1630-5, (2009)

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In vitro activity of Iclaprim against respiratory and bacteremic isolates of Streptococcus pneumoniae. George G Zhanel et al Antimicrob. Agents Chemother. 53, 1690-2, (2009)

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Chromosomal integration of the extended-spectrum beta-lactamase gene blaCTX-M-15 in Salmonella enterica serotype Concord isolates from internationally adopted children. Laëtitia Fabre et al Antimicrob. Agents Chemother. 53, 1808-16, (2009)

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New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Minghua Wang et al Antimicrob. Agents Chemother. 53, 1892-7, (2009)

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Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Lucie Vettoretti et al Antimicrob. Agents Chemother. 53, 1987-97, (2009)

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Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. Thomas D Gootz et al Antimicrob. Agents Chemother. 53, 1998-2004, (2009)

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Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. Michael L Beeton et al Antimicrob. Agents Chemother. 53, 2020-7, (2009)

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Emergence of plasmid-mediated quinolone resistance among non-Typhi Salmonella enterica isolates from humans in the United States. Maria Sjölund-Karlsson et al Antimicrob. Agents Chemother. 53, 2142-4, (2009)

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Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China. Yang Liu et al Antimicrob. Agents Chemother. 53, 2160-2, (2009)

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Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. Helio S Sader et al Antimicrob. Agents Chemother. 53, 2171-5, (2009)

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First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria. Wojciech Duljasz et al Antimicrob. Agents Chemother. 53, 2221-2, (2009)

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Comparative antipneumococcal activities of sulopenem and other drugs. Klaudia Kosowska-Shick et al Antimicrob. Agents Chemother. 53, 2239-47, (2009)

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Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. Azizah Asgarali et al Antimicrob. Agents Chemother. 53, 2274-82, (2009)

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Relationships among Ciprofloxacin, Gatifloxacin, Levofloxacin, and Norfloxacin MICs for Fluoroquinolone-Resistant Escherichia coli Clinical Isolates. Lauren Becnel Boyd, Merry J. Maynard, et al. Antimicrob. Agents Chemother. 53, 229-234, (2009)

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Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Sonia K Morgan-Linnell et al Antimicrob. Agents Chemother. 53, 235-41, (2009)

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Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system. L F Mandsberg et al Antimicrob. Agents Chemother. 53, 2483-91, (2009)

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Molecular characteristics of travel-related extended-spectrum-beta-lactamase-producing Escherichia coli isolates from the Calgary Health Region. Johann D D Pitout et al Antimicrob. Agents Chemother. 53, 2539-43, (2009)

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High prevalence of qnr genes in commensal enterobacteria from healthy children in Peru and Bolivia. Lucia Pallecchi et al Antimicrob. Agents Chemother. 53, 2632-5, (2009)

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Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. Eun Sil Kim et al Antimicrob. Agents Chemother. 53, 2643-5, (2009)

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Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. Geneviève Goy et al Antimicrob. Agents Chemother. 53, 2663-6, (2009)

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AbaR5, a large multiple-antibiotic resistance region found in Acinetobacter baumannii. Virginia Post et al Antimicrob. Agents Chemother. 53, 2667-71, (2009)

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Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics. Ioanna Spyridaki et al Antimicrob. Agents Chemother. 53, 2690-2, (2009)

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Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa. Ellen Z Baum et al Antimicrob. Agents Chemother. 53, 2785-90, (2009)

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Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. K Mesko Meglic et al Antimicrob. Agents Chemother. 53, 287-91, (2009)

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KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. Jason W Bennett et al Antimicrob. Agents Chemother. 53, 292-4, (2009)

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Efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis in vitro and in an experimental model of actinomycetoma in BALB/c mice. Brenda Edith Chacon-Moreno et al Antimicrob. Agents Chemother. 53, 295-7, (2009)

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Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. Enrique Llobet et al Antimicrob. Agents Chemother. 53, 298-302, (2009)

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First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. Marina Cerquetti et al Antimicrob. Agents Chemother. 53, 3112-4, (2009)

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First detection of plasmid-encoded blaOXY beta-lactamase. J J González-López et al Antimicrob. Agents Chemother. 53, 3143-6, (2009)

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Emergence of quinolone-resistant Bordetella pertussis in Japan. Masayuki Ohtsuka et al Antimicrob. Agents Chemother. 53, 3147-9, (2009)

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Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics. Nicole Ritz et al Antimicrob. Agents Chemother. 53, 316-8, (2009)

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Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. Constança Pomba et al Antimicrob. Agents Chemother. 53, 327-8, (2009)

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Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. Stephen P Hawser et al Antimicrob. Agents Chemother. 53, 3280-4, (2009)

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First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. Jussimara Monteiro et al Antimicrob. Agents Chemother. 53, 333-4, (2009)

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Antibacterial properties and mode of action of a short acyl-lysyl oligomer. Fadia Zaknoon et al Antimicrob. Agents Chemother. 53, 3422-9, (2009)

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Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms. Jose L del Pozo et al Antimicrob. Agents Chemother. 53, 35-40, (2009)

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Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii. Marco Maria D'Andrea et al Antimicrob. Agents Chemother. 53, 3528-33, (2009)

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AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. James A Karlowsky et al Antimicrob. Agents Chemother. 53, 3544-8, (2009)

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Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. Wolfgang Haas et al Antimicrob. Agents Chemother. 53, 3552-60, (2009)

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In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms. Kazuko Yamamoto et al Antimicrob. Agents Chemother. 53, 3572-5, (2009)

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oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae. Hong Bin Kim et al Antimicrob. Agents Chemother. 53, 3582-4, (2009)

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Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. Marianne Gunell et al Antimicrob. Agents Chemother. 53, 3832-6, (2009)

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CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. I Roca et al Antimicrob. Agents Chemother. 53, 4013-4, (2009)

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Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. Zuzana Svetlíková et al Antimicrob. Agents Chemother. 53, 4015-8, (2009)

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Characterization of the plasmid-borne quinolone resistance gene qnrB19 in Salmonella enterica serovar Typhimurium. Anna Maria Dionisi et al Antimicrob. Agents Chemother. 53, 4019-21, (2009)

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Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model. Katie Saxton et al Antimicrob. Agents Chemother. 53, 412-20, (2009)

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Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone resistance-determining regions. Yoichi Hirakata et al Antimicrob. Agents Chemother. 53, 4225-30, (2009)

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AI-2/LuxS is involved in increased biofilm formation by Streptococcus intermedius in the presence of antibiotics. Nibras A Ahmed et al Antimicrob. Agents Chemother. 53, 4258-63, (2009)

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Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains. Rekha G Panchal et al Antimicrob. Agents Chemother. 53, 4283-91, (2009)

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Impact of low-level resistance to fluoroquinolones due to qnrA1 and qnrS1 genes or a gyrA mutation on ciprofloxacin bactericidal activity in a murine model of Escherichia coli urinary tract infection. Nicolas Allou et al Antimicrob. Agents Chemother. 53, 4292-7, (2009)

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Novel genetic environment of the carbapenem-hydrolyzing beta-lactamase KPC-2 among Enterobacteriaceae in China. Ping Shen et al Antimicrob. Agents Chemother. 53, 4333-8, (2009)

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Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa. Kristen N Schurek et al Antimicrob. Agents Chemother. 53, 4345-51, (2009)

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In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. Jared L Crandon et al Antimicrob. Agents Chemother. 53, 4352-6, (2009)

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Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Neil Woodford et al Antimicrob. Agents Chemother. 53, 4472-82, (2009)

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ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates. Andrea Endimiani et al Antimicrob. Agents Chemother. 53, 4504-7, (2009)

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Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. Anna Baraniak et al Antimicrob. Agents Chemother. 53, 4565-7, (2009)

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Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. Francis F Arhin et al Antimicrob. Agents Chemother. 53, 4762-71, (2009)

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In vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates. Heather J Adam et al Antimicrob. Agents Chemother. 53, 4915-20, (2009)

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Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. Esther Viedma et al Antimicrob. Agents Chemother. 53, 4930-3, (2009)

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Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. Ryoichi Hamasuna et al Antimicrob. Agents Chemother. 53, 4938-9, (2009)

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Emergence of an Enterobacter hormaechei strain with reduced susceptibility to tigecycline under tigecycline therapy. Claire Daurel et al Antimicrob. Agents Chemother. 53, 4953-4, (2009)

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High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. Véronique Duval et al Antimicrob. Agents Chemother. 53, 4957-8, (2009)

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Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Dongeun Yong et al Antimicrob. Agents Chemother. 53, 5046-54, (2009)

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Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Yudong Liu et al Antimicrob. Agents Chemother. 53, 512-8, (2009)

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Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. Kaddy Barrow et al Antimicrob. Agents Chemother. 53, 5150-4, (2009)

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High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Junying Ma et al Antimicrob. Agents Chemother. 53, 519-24, (2009)

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Detection of the novel extended-spectrum beta-lactamase OXA-161 from a plasmid-located integron in Pseudomonas aeruginosa clinical isolates from Spain. C Juan et al Antimicrob. Agents Chemother. 53, 5288-90, (2009)

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Susceptibilities of 23 Desulfovibrio isolates from humans. Ken-ichi Nakao et al Antimicrob. Agents Chemother. 53, 5308-11, (2009)

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Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Vijaya Bharathi Srinivasan et al Antimicrob. Agents Chemother. 53, 5312-6, (2009)

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In vitro activity of a new quinoline derivative, ER-2, against clinical isolates of Mycoplasma pneumoniae and Mycoplasma hominis. Shilpakala Sainath Rao et al Antimicrob. Agents Chemother. 53, 5317-8, (2009)

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qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. L M Cavaco et al Antimicrob. Agents Chemother. 53, 603-8, (2009)

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Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac). Bo Zheng et al Antimicrob. Agents Chemother. 53, 735-47, (2009)

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Nalidixic acid disk for laboratory detection of ciprofloxacin resistance in Neisseria meningitidis. Rocío Enríquez et al Antimicrob. Agents Chemother. 53, 796-7, (2009)

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SOS regulation of qnrB expression. Minghua Wang et al Antimicrob. Agents Chemother. 53, 821-3, (2009)

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Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. Rodrigo E Mendes et al Antimicrob. Agents Chemother. 53, 843-4, (2009)

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Scalarane sesterterpenoids: semisynthesis and biological activity. Haidy N Kamel et al J. Nat. Prod. 72, 1492-6, (2009)

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Methicillin-resistant Staphylococcus aureus (MRSA)-active metabolites from Platanus occidentalis (American Sycamore). Mohamed A Ibrahim et al J. Nat. Prod. 72, 2141-4, (2009)

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Antimycobacterial flavonoids from the leaf extract of Galenia africana. Sannah P N Mativandlela et al J. Nat. Prod. 72, 2169-71, (2009)

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Neopyrrolomycins with broad spectrum antibacterial activity. D Craig Hopp et al J. Nat. Prod. 72, 276-9, (2009)

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Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua. Shunyan Mo et al J. Nat. Prod. 72, 894-9, (2009)

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Biologically active cannabinoids from high-potency Cannabis sativa. Mohamed M Radwan et al J. Nat. Prod. 72, 906-11, (2009)

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Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa. Volodymyr Samoylenko et al J. Nat. Prod. 72, 92-8, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. Kin Y Tam et al J. Med. Chem. 53, 392-401, (2010)

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From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps. Marco Pieroni et al J. Med. Chem. 53, 4466-80, (2010)

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Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Peng, J.; et al. J. Med. Chem. 53, 61, (2010)

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Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting. Sara N Richter et al Bioorg. Med. Chem. Lett. 20, 1202-4, (2010)

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Syntheses and antibacterial activity studies of new oxazolidinones from nitroso Diels-Alder chemistry. Shanshan Yan et al Bioorg. Med. Chem. Lett. 20, 1302-5, (2010)

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4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: novel C7 moieties of fluoroquinolones as antibacterial agents. Xiaoguang Huang et al Bioorg. Med. Chem. Lett. 20, 2859-63, (2010)

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Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. Wei Shi et al Bioorg. Med. Chem. Lett. 20, 3592-5, (2010)

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InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives. Neelakandan Vidhya Lakshmi et al Bioorg. Med. Chem. Lett. 20, 5054-61, (2010)

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Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles. Amol V Gadakh et al Bioorg. Med. Chem. Lett. 20, 5572-6, (2010)

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Synthesis and evaluation of novel chloropyrrole molecules designed by molecular hybridization of common pharmacophores as potential antimicrobial agents. Rajesh A Rane et al Bioorg. Med. Chem. Lett. 20, 5681-5, (2010)

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A concise, total synthesis and antibacterial evaluation of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one. Nguyen, S. T.; et al. Bioorg. Med. Chem. Lett. 20, 5739, (2010)

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Synthesis, antimicrobial, and mosquito larvicidal activity of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones. E Rajanarendar et al Bioorg. Med. Chem. Lett. 20, 6052-5, (2010)

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Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives. Mehul M Patel et al Bioorg. Med. Chem. Lett. 20, 6324-6, (2010)

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Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents. J Thanusu et al Bioorg. Med. Chem. Lett. 20, 713-7, (2010)

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A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation. Shanmugavel Uma Maheswari et al Bioorg. Med. Chem. Lett. 20, 7278-82, (2010)

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Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines. Mona Saleh et al Bioorg. Med. Chem. Lett. 20, 945-9, (2010)

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Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. Timothy J Opperman et al Bioorg. Med. Chem. 18, 2123-30, (2010)

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Synthesis and biological evaluation of tetracyclic fluoroquinolones as antibacterial and anticancer agents. Salah A Al-Trawneh et al Bioorg. Med. Chem. 18, 5873-84, (2010)

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The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii. Robert W Huigens et al Bioorg. Med. Chem. 18, 663-74, (2010)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. Dražen Pavlovi? et al Bioorg. Med. Chem. 18, 8566-82, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis and antimicrobial activities of 3-O-alkyl analogues of (+)-catechin: improvement of stability and proposed action mechanism. Ki Duk Park et al Eur. J. Med. Chem. 45, 1028-33, (2010)

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Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin. Mahantesha Basanagouda et al Eur. J. Med. Chem. 45, 1151-7, (2010)

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Synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles. R Venkat Ragavan et al Eur. J. Med. Chem. 45, 1173-80, (2010)

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1,3-Dipolar cycloaddition of C-aryl-N-phenylnitrones to (R)-1-(1-phenylethyl)-3-[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: synthesis and antimycobacterial evaluation of enantiomerically pure spiroisoxazolidines. Raju Suresh Kumar et al Eur. J. Med. Chem. 45, 124-33, (2010)

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Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides. V Kanagarajan et al Eur. J. Med. Chem. 45, 1583-9, (2010)

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Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones. Neda Adibpour et al Eur. J. Med. Chem. 45, 19-24, (2010)

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Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. G V Suresh Kumar et al Eur. J. Med. Chem. 45, 2063-74, (2010)

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Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory-antimicrobial agents. Pawan K Sharma et al Eur. J. Med. Chem. 45, 2650-5, (2010)

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Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation. Davinder Kumar et al Eur. J. Med. Chem. 45, 2806-16, (2010)

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Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents. Balram Soni et al Eur. J. Med. Chem. 45, 2938-42, (2010)

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Novel 6,8-dibromo-4(3H)quinazolinone derivatives of anti-bacterial and anti-fungal activities. Mosaad S Mohamed et al Eur. J. Med. Chem. 45, 3311-9, (2010)

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New quinoline derivatives: Synthesis and investigation of antibacterial and antituberculosis properties Eswaran, S.; et al. Eur. J. Med. Chem. 45, 3374, (2010)

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Substituted dihydronaphthalenes as efflux pump inhibitors of Staphylococcus aureus. Niranjan Thota et al Eur. J. Med. Chem. 45, 3607-16, (2010)

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Synthesis and in vitro microbiological evaluation of novel 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidinones. S Chitra et al Eur. J. Med. Chem. 45, 367-71, (2010)

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Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety. K. D. Thomas, et al., Eur. J. Med. Chem. 45, 3803-3810, (2010)

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Novel three-component domino reactions of ketones, isatin and amino acids: synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines. Raju Suresh Kumar et al Eur. J. Med. Chem. 45, 411-22, (2010)

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Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents. Om Prakash et al Eur. J. Med. Chem. 45, 4252-7, (2010)

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Anti-tubercular agents. Part 5: synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. A. Kamal, et al., Eur. J. Med. Chem. 45, 4545-4553, (2010)

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Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety. Channamata Shankara Naveena et al Eur. J. Med. Chem. 45, 4708-19, (2010)

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Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives. Keshari Kishore Jha et al Eur. J. Med. Chem. 45, 4963-7, (2010)

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Synthesis and antimicrobial studies of thiazolotriazinones. Mari Sithambaram Karthikeyan et al Eur. J. Med. Chem. 45, 5039-43, (2010)

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Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines. Nimesh R Kamdar et al Eur. J. Med. Chem. 45, 5056-63, (2010)

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Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. G V Suresh Kumar et al Eur. J. Med. Chem. 45, 5120-9, (2010)

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Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives. K Manjunatha et al Eur. J. Med. Chem. 45, 5225-33, (2010)

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A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation. Prasanna, P.; et al. Eur. J. Med. Chem. 45, 5653, (2010)

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The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains. Diane Hardej et al Eur. J. Med. Chem. 45, 5827-32, (2010)

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Molecular properties prediction, synthesis and antimicrobial activity of some newer oxadiazole derivatives. Mohammed Afroz Bakht et al Eur. J. Med. Chem. 45, 5862-9, (2010)

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Synthesis and antitubercular activities of substituted benzoic acid N'-(substituted benzylidene/furan-2-ylmethylene)-N-(pyridine-3-carbonyl)-hydrazides. Pradeep Kumar et al Eur. J. Med. Chem. 45, 6085-9, (2010)

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Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives. Shanmugam Srinivasan et al Eur. J. Med. Chem. 45, 6101-5, (2010)

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Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring. S K Bharti et al Eur. J. Med. Chem. 45, 651-60, (2010)

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Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives. Pradeepkumar M Ronad et al Eur. J. Med. Chem. 45, 85-9, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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New 1,3-oxazolo[4,5-c]quinoline derivatives: synthesis and evaluation of antibacterial and antituberculosis properties. Sumesh Eswaran et al Eur. J. Med. Chem. 45, 957-66, (2010)

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Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. Christopher A Elkins et al Antimicrob. Agents Chemother. 54, 1007-15, (2010)

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Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. M Indriati Hood et al Antimicrob. Agents Chemother. 54, 1029-41, (2010)

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Spread of a chromosomal cefixime-resistant penA gene among different Neisseria gonorrhoeae lineages. Makoto Ohnishi et al Antimicrob. Agents Chemother. 54, 1060-7, (2010)

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Clinical pharmacodynamics of cefepime in patients infected with Pseudomonas aeruginosa. Jared L Crandon et al Antimicrob. Agents Chemother. 54, 1111-6, (2010)

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Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals. Li-Yang Hsu et al Antimicrob. Agents Chemother. 54, 1173-8, (2010)

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Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. Bartolome Moya et al Antimicrob. Agents Chemother. 54, 1213-7, (2010)

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Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. Anna Fàbrega et al Antimicrob. Agents Chemother. 54, 1218-25, (2010)

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Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. Mirva Lehtopolku et al Antimicrob. Agents Chemother. 54, 1232-6, (2010)

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Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline. M Hentschke et al Antimicrob. Agents Chemother. 54, 1319-22, (2010)

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High prevalence of ST131 isolates producing CTX-M-15 and CTX-M-14 among extended-spectrum-beta-lactamase-producing Escherichia coli isolates from Canada. Gisele Peirano et al Antimicrob. Agents Chemother. 54, 1327-30, (2010)

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Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. Tsai-Ling Lauderdale et al Antimicrob. Agents Chemother. 54, 1338-42, (2010)

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Detection of KPC in Acinetobacter spp. in Puerto Rico. Iraida E Robledo et al Antimicrob. Agents Chemother. 54, 1354-7, (2010)

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In vitro pharmacodynamics of levofloxacin and other aerosolized antibiotics under multiple conditions relevant to chronic pulmonary infection in cystic fibrosis. Paula King et al Antimicrob. Agents Chemother. 54, 143-8, (2010)

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Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion. Sin-Sien Jiang et al Antimicrob. Agents Chemother. 54, 1564-71, (2010)

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Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and -resistant Acinetobacter baumannii isolates. Paul G Higgins et al Antimicrob. Agents Chemother. 54, 1613-5, (2010)

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High diversity of extended-spectrum beta-lactamases in Escherichia coli isolates from Italian broiler flocks. Valeria Bortolaia et al Antimicrob. Agents Chemother. 54, 1623-6, (2010)

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Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. Gill SC, et al. Antimicrob. Agents Chemother. 5th ed., 54, 1678-1683, (2010)

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Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. Emma Padilla et al Antimicrob. Agents Chemother. 54, 177-83, (2010)

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Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Matthew G Blango et al Antimicrob. Agents Chemother. 54, 1855-63, (2010)

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In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. Brian J Morrow et al Antimicrob. Agents Chemother. 54, 1955-64, (2010)

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Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan. Yu-Chi Lin et al Antimicrob. Agents Chemother. 54, 2078-84, (2010)

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Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Maria Tomás et al Antimicrob. Agents Chemother. 54, 2219-24, (2010)

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KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea. Ji-Young Rhee et al Antimicrob. Agents Chemother. 54, 2278-9, (2010)

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In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. Malcolm G P Page et al Antimicrob. Agents Chemother. 54, 2291-302, (2010)

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Semimechanistic pharmacokinetic-pharmacodynamic model with adaptation development for time-kill experiments of ciprofloxacin against Pseudomonas aeruginosa. Nicolas Grégoire et al Antimicrob. Agents Chemother. 54, 2379-84, (2010)

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Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal. Renato Pires et al Antimicrob. Agents Chemother. 54, 2677-80, (2010)

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Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. Moran G Goren et al Antimicrob. Agents Chemother. 54, 2687-91, (2010)

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Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. Li-Yueh Huang et al Antimicrob. Agents Chemother. 54, 2699-703, (2010)

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Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France. A Morvan et al Antimicrob. Agents Chemother. 54, 2728-31, (2010)

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Genomewide screening for novel genetic variations associated with ciprofloxacin resistance in Bacillus anthracis. Masakuni Serizawa et al Antimicrob. Agents Chemother. 54, 2787-92, (2010)

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A rapid antimicrobial susceptibility test for Bacillus anthracis. Linda M Weigel et al Antimicrob. Agents Chemother. 54, 2793-800, (2010)

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Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). Emilio Pérez-Trallero et al Antimicrob. Agents Chemother. 54, 2953-9, (2010)

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Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. Azita Leavitt et al Antimicrob. Agents Chemother. 54, 3002-6, (2010)

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Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Lisa M Oppegard et al Antimicrob. Agents Chemother. 54, 3011-4, (2010)

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In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center. Michael J Zapor et al Antimicrob. Agents Chemother. 54, 3015-7, (2010)

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Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). Daryl J Hoban et al Antimicrob. Agents Chemother. 54, 3031-4, (2010)

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Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrobial Resistance Trends (SMART). Stephen P Hawser et al Antimicrob. Agents Chemother. 54, 3043-6, (2010)

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Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. Il Kwon Bae et al Antimicrob. Agents Chemother. 54, 3068-9, (2010)

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The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. Takehiko Mima et al Antimicrob. Agents Chemother. 54, 3113-20, (2010)

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Chip calorimetry for fast and reliable evaluation of bactericidal and bacteriostatic treatments of biofilms. F Buchholz et al Antimicrob. Agents Chemother. 54, 312-9, (2010)

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Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. Sébastien Coyne et al Antimicrob. Agents Chemother. 54, 333-40, (2010)

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Molecular epidemiology of metallo-beta-lactamase-producing Pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. Orjan Samuelsen et al Antimicrob. Agents Chemother. 54, 346-52, (2010)

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First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital. Giuseppe Valenza et al Antimicrob. Agents Chemother. 54, 3493-7, (2010)

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In vitro activity of azithromycin against nontyphoidal Salmonella enterica. Marianne Gunell et al Antimicrob. Agents Chemother. 54, 3498-501, (2010)

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Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. Didier Hocquet et al Antimicrob. Agents Chemother. 54, 3512-5, (2010)

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Mutant selection window and characterization of allelic diversity for ciprofloxacin-resistant mutants of Rhodococcus equi. Hidekazu Niwa et al Antimicrob. Agents Chemother. 54, 3520-3, (2010)

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N-acetylcysteine-mediated modulation of bacterial antibiotic susceptibility. Manish Goswami et al Antimicrob. Agents Chemother. 54, 3529-30, (2010)

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Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. Sohei Harada et al Antimicrob. Agents Chemother. 54, 3545-50, (2010)

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Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum beta-lactamases: a prospective study with Swedish volunteers. Thomas Tängdén et al Antimicrob. Agents Chemother. 54, 3564-8, (2010)

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Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes. Edel O'Regan et al Antimicrob. Agents Chemother. 54, 367-74, (2010)

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Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. Jürgen A Bohnert et al Antimicrob. Agents Chemother. 54, 3770-5, (2010)

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Different classes of antibiotics differentially influence shiga toxin production. Colleen Marie McGannon et al Antimicrob. Agents Chemother. 54, 3790-8, (2010)

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Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. C R Bourne et al Antimicrob. Agents Chemother. 54, 3825-33, (2010)

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First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. Lei Dai et al Antimicrob. Agents Chemother. 54, 3953-5, (2010)

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Complete nucleotide sequence of Klebsiella pneumoniae multidrug resistance plasmid pKP048, carrying blaKPC-2, blaDHA-1, qnrB4, and armA. Yan Jiang et al Antimicrob. Agents Chemother. 54, 3967-9, (2010)

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Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. Michelle M Butler et al Antimicrob. Agents Chemother. 54, 3974-7, (2010)

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In vitro antimicrobial activity and mutant prevention concentration of colistin against Acinetobacter baumannii. Yun Cai et al Antimicrob. Agents Chemother. 54, 3998-9, (2010)

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Oral treatment options for ambulatory patients with urinary tract infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli. Simon Auer et al Antimicrob. Agents Chemother. 54, 4006-8, (2010)

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Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. Douglas J Biedenbach et al Antimicrob. Agents Chemother. 54, 4009-11, (2010)

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Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. Hidemasa Nakaminami et al Antimicrob. Agents Chemother. 54, 4107-11, (2010)

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Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. Jingjing Zhao et al Antimicrob. Agents Chemother. 54, 4219-24, (2010)

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Membrane efflux and influx modulate both multidrug resistance and virulence of Klebsiella pneumoniae in a Caenorhabditis elegans model. Suzanne Bialek et al Antimicrob. Agents Chemother. 54, 4373-8, (2010)

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Efficacy of Daptomycin against Bacillus anthracis in a murine model of anthrax spore inhalation. Henry S Heine et al Antimicrob. Agents Chemother. 54, 4471-3, (2010)

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Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. Benoît Doublet et al Antimicrob. Agents Chemother. 54, 45-51, (2010)

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Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. Ronald N Jones et al Antimicrob. Agents Chemother. 54, 4518-9, (2010)

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Emergence and Distribution of Plasmids Bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan. Te-Li Chen et al Antimicrob. Agents Chemother. 54, 4575-81, (2010)

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Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. Patrick Basset et al Antimicrob. Agents Chemother. 54, 4589-95, (2010)

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The development of ciprofloxacin resistance in Pseudomonas aeruginosa involves multiple response stages and multiple proteins. Hsun-Cheng Su et al Antimicrob. Agents Chemother. 54, 4626-35, (2010)

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Synthesis and spectrum of the neoglycoside ACHN-490. James B Aggen et al Antimicrob. Agents Chemother. 54, 4636-42, (2010)

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Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. Chung-Ter Huang et al Antimicrob. Agents Chemother. 54, 4893-5, (2010)

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Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum ?-lactamase in serogroup O26. Glenn Buvens et al Antimicrob. Agents Chemother. 54, 4907-9, (2010)

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Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. Jun Okuda et al Antimicrob. Agents Chemother. 54, 4917-9, (2010)

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Overexpression of the adeB gene in clinical isolates of tigecycline-nonsusceptible Acinetobacter baumannii without insertion mutations in adeRS. Jun-Ren Sun et al Antimicrob. Agents Chemother. 54, 4934-8, (2010)

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Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus. Hwang-Soo Joo et al Antimicrob. Agents Chemother. 54, 4942-4, (2010)

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Frequency of spontaneous resistance to fosfomycin combined with different antibiotics in Pseudomonas aeruginosa. Alexandro Rodríguez-Rojas et al Antimicrob. Agents Chemother. 54, 4948-9, (2010)

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In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. Paul G Higgins et al Antimicrob. Agents Chemother. 54, 5021-7, (2010)

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Outbreak of meropenem-resistant Serratia marcescens comediated by chromosomal AmpC beta-lactamase overproduction and outer membrane protein loss. Borum Suh et al Antimicrob. Agents Chemother. 54, 5057-61, (2010)

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Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. Nazia Kamal et al Antimicrob. Agents Chemother. 54, 506-8, (2010)

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Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. Jared L Crandon et al Antimicrob. Agents Chemother. 54, 5115-9, (2010)

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In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. Ji-Woong Jeong et al Antimicrob. Agents Chemother. 54, 5359-62, (2010)

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Microbiologic and clinical implications of bacteremia due to extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae with or without plasmid-mediated AmpC beta-lactamase DHA-1. Chen-Hsiang Lee et al Antimicrob. Agents Chemother. 54, 5395-8, (2010)

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Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. Julien Brillault et al Antimicrob. Agents Chemother. 54, 543-5, (2010)

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In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance. Catharine C Bulik et al Antimicrob. Agents Chemother. 54, 557-9, (2010)

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Nonclonal emergence of colistin-resistant Klebsiella pneumoniae isolates from blood samples in South Korea. Ji-Yoeun Suh et al Antimicrob. Agents Chemother. 54, 560-2, (2010)

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Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. Qiwen Yang et al Antimicrob. Agents Chemother. 54, 573-7, (2010)

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First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate. Delphine Girlich et al Antimicrob. Agents Chemother. 54, 578-9, (2010)

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SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. María B Sánchez et al Antimicrob. Agents Chemother. 54, 580-1, (2010)

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Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci. Kim Credito et al Antimicrob. Agents Chemother. 54, 673-7, (2010)

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Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. Lucia Pallecchi et al Antimicrob. Agents Chemother. 54, 678-82, (2010)

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Transferable quinolone resistance in Vibrio cholerae. Hong Bin Kim et al Antimicrob. Agents Chemother. 54, 799-803, (2010)

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Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. Carlos Juan et al Antimicrob. Agents Chemother. 54, 846-51, (2010)

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Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. Milagrosa Montes et al Antimicrob. Agents Chemother. 54, 93-7, (2010)

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Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum. Mallika Kumarihamy et al J. Nat. Prod. 73, 1250-3, (2010)

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Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia. Minkyun Na et al J. Nat. Prod. 73, 383-7, (2010)

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Membrane transporters in drug development Giacomini, K.M., et al. Nat. Rev. Drug Discov. 9, 215-236, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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Design, synthesis, and biological evaluation of new cinnamic derivatives as antituberculosis agents. Prithwiraj De et al J. Med. Chem. 54, 1449-61, (2011)

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Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA). Ha Young Kim et al J. Med. Chem. 54, 3268-82, (2011)

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Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. Stefano Sabatini et al J. Med. Chem. 54, 5722-36, (2011)

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N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. Timothy A Wencewicz et al J. Med. Chem. 54, 6843-58, (2011)

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Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. Wei Shi et al Bioorg. Med. Chem. Lett. 21, 1060-3, (2011)

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Design and synthesis of potent Gram-negative specific LpxC inhibitors. U Faruk Mansoor et al Bioorg. Med. Chem. Lett. 21, 1155-61, (2011)

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Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents. B China Raju et al Bioorg. Med. Chem. Lett. 21, 2855-9, (2011)

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Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. Zeba N Siddiqui et al Bioorg. Med. Chem. Lett. 21, 2860-5, (2011)

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A green expedient synthesis of pyridopyrimidine-2-thiones and their antitubercular activity. Stephen Michael Rajesh et al Bioorg. Med. Chem. Lett. 21, 3012-6, (2011)

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Design, synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-aminomethylpiperidin-1-yl)fluoroquinolone derivatives. Yun Chai et al Bioorg. Med. Chem. Lett. 21, 3377-80, (2011)

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Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles. Ebraheem Abdu Musad et al Bioorg. Med. Chem. Lett. 21, 3536-40, (2011)

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Synthesis and antimycobacterial activity of highly functionalized tetrahydro-4(1H)-pyridinones. Velanganni Paul Alex Raja et al Bioorg. Med. Chem. Lett. 21, 3881-4, (2011)

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7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. Wei-Chu Xu et al Bioorg. Med. Chem. Lett. 21, 4197-202, (2011)

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Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Christophe Antczak et al Bioorg. Med. Chem. Lett. 21, 4528-32, (2011)

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Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones. Kevin R Marks et al Bioorg. Med. Chem. Lett. 21, 4585-8, (2011)

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The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation. Rajesh H Tale et al Bioorg. Med. Chem. Lett. 21, 4648-51, (2011)

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Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor. Dharmarajan Sriram et al Bioorg. Med. Chem. Lett. 21, 5149-54, (2011)

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Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. Son T Nguyen et al Bioorg. Med. Chem. Lett. 21, 5961-3, (2011)

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Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. Jigar A Makawana et al Bioorg. Med. Chem. Lett. 21, 6166-9, (2011)

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The synthesis of xanthones, xanthenediones, and spirobenzofurans: Their antibacterial and antifungal activity. Justin J Omolo et al Bioorg. Med. Chem. Lett. 21, 7085-8, (2011)

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Molecular properties prediction and synthesis of novel 1,3,4-oxadiazole analogues as potent antimicrobial and antitubercular agents. Mohamed Jawed Ahsan et al Bioorg. Med. Chem. Lett. 21, 7246-50, (2011)

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Exploration of in vitro time point quantitative evaluation of newly synthesized benzimidazole and benzothiazole derivatives as potential antibacterial agents Bandyopadhyay, P.; et al. Bioorg. Med. Chem. Lett. 21, 7306-7309, (2011)

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Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. Yasuhiro Horita et al Bioorg. Med. Chem. Lett. 21, 899-903, (2011)

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Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-5-amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives. Yibin Zhang et al Bioorg. Med. Chem. Lett. 21, 928-31, (2011)

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Synthesis and biological evaluation of tetracyclic thienopyridones as antibacterial and antitumor agents. Salah A Al-Trawneh et al Bioorg. Med. Chem. 19, 2541-8, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents. Burchak, O. N.; et al. Bioorg. Med. Chem. 19, 3204, (2011)

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Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides. Raju Ranjith Kumar et al Bioorg. Med. Chem. 19, 3444-50, (2011)

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Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1H)-quinolones. Wube, A. A.; et al. Bioorg. Med. Chem. 19, 567, (2011)

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Chemical synthesis, biological evaluation and structure-activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as potential antimycobacterial agents. Céline Deraeve et al Bioorg. Med. Chem. 19, 6225-32, (2011)

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In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities. Abbas Gholipour Shilabin et al Bioorg. Med. Chem. 19, 6628-32, (2011)

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Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus. Naresh Sunduru et al Eur. J. Med. Chem. 46, 1232-44, (2011)

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Synthesis, stereochemistry, antimicrobial evaluation and QSAR studies of 2,6-diaryltetrahydropyran-4-one thiosemicarbazones. S Umamatheswari et al Eur. J. Med. Chem. 46, 1415-24, (2011)

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Synthesis and biological evaluation of some 4-functionalized-pyrazoles as antimicrobial agents. Pawan K Sharma et al Eur. J. Med. Chem. 46, 1425-32, (2011)

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A facile, one-pot synthesis, characterization and antimicrobial activity of o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids. Nida N Farshori et al Eur. J. Med. Chem. 46, 1433-8, (2011)

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Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. Bakr F Abdel-Wahab et al Eur. J. Med. Chem. 46, 1505-11, (2011)

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Synthesis and antibacterial property of pyrrolopyrano quinolinones and pyrroloquinolines. Mathesan Jayagobi et al Eur. J. Med. Chem. 46, 2075-82, (2011)

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Synthesis of N-substituted 2-[(1E)-alkenyl]-4-(1H)-quinolone derivatives as antimycobacterial agents against non-tubercular mycobacteria. Abraham A Wube et al Eur. J. Med. Chem. 46, 2091-101, (2011)

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?-Carbolines and their ring-opened analogs: synthesis and evaluation against fungal and bacterial opportunistic pathogens. Tryphon K Mazu et al Eur. J. Med. Chem. 46, 2378-85, (2011)

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New quinolin-4-yl-1,2,3-triazoles carrying amides, sulphonamides and amidopiperazines as potential antitubercular agents. K D Thomas et al Eur. J. Med. Chem. 46, 2503-12, (2011)

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Synthesis and antimicrobial activity of some novel dicationic sulphonophanes. Perumal Rajakumar et al Eur. J. Med. Chem. 46, 3093-8, (2011)

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Synthesis and anti-mycobacterial activities of triazoloquinolones. Antonio Carta et al Eur. J. Med. Chem. 46, 320-6, (2011)

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Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones. Ahmed Kamal et al Eur. J. Med. Chem. 46, 3274-81, (2011)

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Synthesis and in vitro antimycobacterial activity of 8-OCH(3) ciprofloxacin methylene and ethylene isatin derivatives. Lian-Shun Feng et al Eur. J. Med. Chem. 46, 341-8, (2011)

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Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolone derivatives. Rajnish Kumar et al Eur. J. Med. Chem. 46, 3543-50, (2011)

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Synthesis, antimicrobial evaluation and QSAR analysis of novel nalidixic acid based 1,2,4-triazole derivatives. Nisha Aggarwal et al Eur. J. Med. Chem. 46, 4089-99, (2011)

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Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents. Rahul V Patel et al Eur. J. Med. Chem. 46, 4354-65, (2011)

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A facile four-component sequential protocol in the expedient synthesis of novel 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones in water and their antitubercular evaluation. Pethaiah Gunasekaran et al Eur. J. Med. Chem. 46, 4530-6, (2011)

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Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives. Xi-Wei Wu et al Eur. J. Med. Chem. 46, 4625-33, (2011)

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Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties. K D Thomas et al Eur. J. Med. Chem. 46, 4834-45, (2011)

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Synthesis of 3-heteroarylthioquinoline derivatives and their in vitro antituberculosis and cytotoxicity studies. Selvam Chitra et al Eur. J. Med. Chem. 46, 4897-903, (2011)

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New fluorine-containing hydrazones active against MDR-tuberculosis. Eva Vav?íková et al Eur. J. Med. Chem. 46, 4937-45, (2011)

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Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents. Om Prakash et al Eur. J. Med. Chem. 46, 5065-73, (2011)

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Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents. K D Thomas et al Eur. J. Med. Chem. 46, 5283-92, (2011)

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A facile synthesis of carbocycle-fused mono and bis-1,2,3-selenadiazoles and their antimicrobial and antimycobacterial studies. Selvam Chitra et al Eur. J. Med. Chem. 46, 5465-72, (2011)

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Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study. Alaa A-M Abdel-Aziz et al Eur. J. Med. Chem. 46, 5487-97, (2011)

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1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. Tarunkumar Nanjibhai Akhaja et al Eur. J. Med. Chem. 46, 5573-9, (2011)

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L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies. T Indumathi et al Eur. J. Med. Chem. 46, 5580-90, (2011)

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Synthesis and structure-activity relationship studies of 4-arylthiosemicarbazides as topoisomerase IV inhibitors with Gram-positive antibacterial activity. Search for molecular basis of antibacterial activity of thiosemicarbazides. Agata Siwek et al Eur. J. Med. Chem. 46, 5717-26, (2011)

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Synthesis of lipophilic dimeric C-7/C-7-linked ciprofloxacin and C-6/C-6-linked levofloxacin derivatives. Versatile in vitro biological evaluations of monomeric and dimeric fluoroquinolone derivatives as potential antitumor, antibacterial or antimycobacterial agents. Joëlle Azéma et al Eur. J. Med. Chem. 46, 6025-38, (2011)

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Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Nandita Sinha et al Eur. J. Med. Chem. 46, 618-30, (2011)

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Discovery of a novel nitroimidazolyl-oxazolidinone hybrid with potent anti Gram-positive activity: Synthesis and antibacterial evaluation. Ali Khalaj et al Eur. J. Med. Chem. 46, 65-70, (2011)

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In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. A Briales et al Antimicrob. Agents Chemother. 55, 1266-9, (2011)

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Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. Mark I Garvey et al Antimicrob. Agents Chemother. 55, 190-6, (2011)

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Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor. Arunasree M Kalle et al Antimicrob. Agents Chemother. 55, 439-42, (2011)

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Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. Vanessa G Allen et al Antimicrob. Agents Chemother. 55, 703-12, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Brominated arginine-derived alkaloids from the red sea sponge Suberea mollis. Lamiaa A Shaala et al J. Nat. Prod. 74, 1517-20, (2011)

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Bioactive sesqui- and diterpenoids from the Argentine liverwort Porella chilensis. Miguel Gilabert et al J. Nat. Prod. 74, 574-9, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections Brown, M. F.; et al. J. Med. Chem. 2nd ed., 55, 914-923, (2012)

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Camphorsulfonic acid catalysed facile tandem double Friedlander annulation protocol for the synthesis of phenoxy linked bisquinoline derivatives and discovery of antitubercular agents. Nidhin Paul et al Bioorg. Med. Chem. Lett. 22, 1643-8, (2012)

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Anti-mycobacterial activities of some cationic and anionic calix[4]arene derivatives. Maxime Mourer et al Bioorg. Med. Chem. 20, 2035-41, (2012)

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Synthesis, antimicrobial and anticancer activities of a novel series of diphenyl 1-(pyridin-3-yl)ethylphosphonates. Mohamed F Abdel-Megeed et al Bioorg. Med. Chem. 20, 2252-8, (2012)

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Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines. Jamal Krim et al Bioorg. Med. Chem. 20, 480-6, (2012)

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Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug. Mariappan Babu et al Eur. J. Med. Chem. 47, 608-14, (2012)

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Synthesis and antibacterial activity of naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds. Kai Lv et al Eur. J. Med. Chem. 47, 619-25, (2012)

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Synthesis and biological evaluation of some thiazolidinones as antimicrobial agents. Divyesh Patel et al Eur. J. Med. Chem. 48, 354-62, (2012)

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Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents. Ranjith P Karuvalam et al Eur. J. Med. Chem. 49C, 172-82, (2012)

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Regioselective synthesis and antimicrobial activities of some novel aryloxyacetic acid derivatives. Bakr F Abdel-Wahab et al Eur. J. Med. Chem. 50, 55-62, (2012)

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