• USA Home
  • 25745 - Chloroquine diphosphate salt

EMAIL THIS PAGE TO A FRIEND

25745 Fluka

Chloroquine diphosphate salt

≥96.0% (TLC)

Synonym: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

  • CAS Number 50-63-5

  • Empirical Formula (Hill Notation) C18H26ClN3 · 2H3PO4

  • Molecular Weight 515.86

  •  Beilstein Registry Number 4223142

  •  EC Number 200-055-2

  •  MDL number MFCD00069852

Purchase

Properties

assay   ≥96.0% (TLC)
impurities   ≤3% water
mp   200 °C (dec.)(lit.)
solubility   H2O: soluble50 mg/mL, clear

Description

Other Notes

Lysosomotropic drug1

This product has been replaced by C6628-SIGMA | Chloroquine diphosphate salt solid, ≥98%

Price and Availability

Customers Also Viewed

Amodiaquin dihydrochloride dihydrate

analytical standard

Chloroquine phosphate

pharmaceutical secondary standard; traceable to USP

European Pharmacopoeia (EP) Reference Standard

Mefloquine hydrochloride

≥98% (HPLC), powder

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
22
Safety Statements (Europe) 
22-24/25
WGK Germany 
3
RTECS 
VB2450000

Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. D.D. Hong Anal. Profiles Drug Subst. N.Y. 5, 61, (1976)

Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy. Michaelides M, Stover NB, Francis PJ, et al. Arch. Ophthal. 129(1), 30-9, (2011)

Loading...


High absolute bioavailability of methylene blue given as an aqueous oral formulation. Walter-Sack I, Rengelshausen J, Oberwittler H, et al. Eur. J. Clin. Pharmacol. 65(2), 179-89, (2009)

Loading...


Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study. Sasaki K, Tsuno NH, Sunami E, et al. Anticancer Drugs 23(7), 675-82, (2012)

Loading...


Effect of chloroquine phosphate treatment on serum MMP-9 and TIMP-1 levels in patients with systemic lupus erythematosus. Lesiak A, Narbutt J, Sysa-Jedrzejowska A, et al. Lupus 19(6), 683-8, (2010)

Loading...


Blood parasites mediate morph-specific maintenance costs in a colour polymorphic wild bird. Karell P, Ahola K, Karstinen T, et al. J. Evol. Biol. 24(8), 1783-92, (2011)

Loading...


[A case of imported vivax malaria in Tomsk]. Chernyshova NP, Portniagina EV, Lukashova LV, et al. Med. Parazitol. (Mosk.) (4), 49-50, (2012)

Loading...


[The specific features of imported Plasmodium vivax malaria, Chesson strain type]. Rabinovich SA, Kondrashin AV, Tokmalaev AK, et al. Med. Parazitol. (Mosk.) (4), 7-11, (2012)

Loading...


Fever in a 20-year-old returned traveler. Liang SY, Westblade LF, Mehrtens J, et al. Clin. Infect. Dis. 56(3), 423; answers 461-2, (2013)

Loading...


[Monitoring delagil (chloroquine) efficacy against imported Plasmodium vivax strains]. Rabinovich SA, Tokmalaev AK, Kukina IV, et al. Med. Parazitol. (Mosk.) (4), 46-8, (2010)

Loading...


Scar sarcoidosis with a 50-year interval between an accident and onset of lesions. de Almeida HL and Fiss RC Dermatol. Online J. 14(11), 18, (2008)

Loading...


Fungal recognition enhances mannose receptor shedding through dectin-1 engagement. Gazi U J. Biol. Chem. 286(10), 7822-9, (2011)

Loading...


Lupus erythematosus tumidus: response to antimalarial treatment in 36 patients with emphasis on smoking. Kreuter A, Gaifullina R, Tigges C, et al. Arch. Dermatol. 145(3), 244-8, (2009)

Loading...


In utero exposure to chloroquine alters sexual development in the male fetal rat. Clewell RA, Pluta L, Thomas RS, et al. Toxicol. Appl. Pharmacol. 237(3), 366-74, (2009)

Loading...


in vitro and in vivo properties of ellagic acid in malaria treatment. Patrice Njomnang Soh et al Antimicrob. Agents Chemother. 53, 1100-6, (2009)

Loading...


Identification of Plasmodium relictum causing mortality in penguins (Spheniscus magellanicus) from São Paulo Zoo, Brazil. Bueno MG, Lopez RP, de Menezes RM, et al. Vet. Parasitol. 173(1-2), 123-7, (2010)

Loading...


Monitoring of clinical efficacy and in vitro sensitivity of Plasmodium vivax to chloroquine in area along Thai Myanmar border during 2009-2010. Muhamad P, Ruengweerayut R, Chacharoenkul W, et al. Malaria Journal 10(1), 44, (2011)

Loading...


Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Jiang PD, Zhao YL, Deng XQ, et al. Biomed. Pharmacother. 64(9), 609-14, (2010)

Loading...


Toxic epidermal necrolysis-like cutaneous lupus erythematosus: A series of three patients. Cisneros CG, Romiti R, Santi CG, et al. Acta Derm. Venereol. 90(2), 175-8, (2010)

Loading...


Variant Plasmodium ovale isolated from a patient infected in Ghana. Tordrup D, Virenfeldt J, Andersen FF, et al. Malaria Journal 10(1), 15, (2011)

Loading...


Amyloid-beta accumulation caused by chloroquine injections precedes ER stress and autophagosome formation in rat skeletal muscle. Ikezoe K, Furuya H, Arahata H, et al. Acta Neuropathol. 117(5), 575-82, (2009)

Loading...


Seventy-five years of Resochin in the fight against malaria. Jensen M and Mehlhorn H Parasitol. Res. 105(3), 609-27, (2009)

Loading...


In-vitro culture of Plasmodium falciparum: utility of modified (RPNI) medium for drug-sensitivity studies using SYBR Green I assay. Singh S, Srivastava RK, Srivastava M, et al. Exp. Parasitol. 127(1), 318-21, (2011)

Loading...


Chloroquine -induced hair depigmentation. Di Giacomo TB, Valente NY, and Nico MM Lupus 18(3), 264-6, (2009)

Loading...


Design, synthesis and anti-itch activity evaluation of aromatic amino acid derivatives as gastrin-releasing peptide receptor antagonists. Yao RS, Li TT, Xu J, et al. Med. Chem. 8(5), 865-73, (2012)

Loading...


Role of curcumin on chloroquine phosphate-induced reproductive toxicity. Desai KR, Dattani JJ, Rajput DK, et al. Drug Chem. Toxicol. 35(2), 184-91, (2012)

Loading...


Doxorubicin and chloroquine coencapsulated liposomes: preparation and improved cytotoxicity on human breast cancer cells. Qiu L, Yao M, Gao M, et al. J. Liposome Res. 22(3), 245-53, (2012)

Loading...


[Diagnostic methods for chloroquine diphosphate induced retinopathy in systemic lupus erythematosus]. Rodrigues LD, Shinjo SK, Oyamada MK, et al. Arq. Bras. Oftalmol. 72(3), 313-20, (2009)

Loading...


Merck 14,2163

Beil. 22,IV,4639

Structure Index 1, 413:E:6

Related Products

replaced by

Product #

Description

Add to Cart

C6628 Chloroquine diphosphate salt, solid, ≥98%

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?