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28803 Fluka

Fluorescein sodium salt

indicator, 98.5-100.5%

Synonym: Acid Yellow 73, D&C;Yellow No. 8, NaFl, NaFluo, Sodium fluorescein, Uranine

  • CAS Number 518-47-8

  • Empirical Formula (Hill Notation) C20H10Na2O5

  • Molecular Weight 376.27

  •  Beilstein Registry Number 3833041

  •  Colour Index Number 45350

  •  EC Number 208-253-0

  •  MDL number MFCD00167039

  •  PubChem Substance ID 24857309

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Properties

Related Categories Adsorption Indicators, Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Fluorescein and Derivatives,
grade   indicator
assay   98.5-100.5% (calc. on dry substance)
  98.5-100.5%
loss   ≤10% loss on drying, 105 °C
anion traces   chloride (Cl-): ≤3500 mg/kg
  sulfate (SO42-): ≤1.2%
fluorescence   λex 460 nm; λem 515 nm(lit.)
suitability   complies for TLC

Description

General description

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TruPAGE™ Pre-cast Polyacrylamide Gels


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Fluorescein

Reag. Ph. Eur., free acid

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Dye content 95 %

Fluorescein sodium salt

used as fluorescent tracer

Fluorescein sodium salt

BioReagent, suitable for fluorescence

Fluorescein sodium salt

p.a., for source staining

Safety & Documentation

Safety Information

WGK Germany 
1

Documents

Certificate of Analysis

Protocols & Articles

Articles

Determination of Water Content in Fluorescein di-sodium salt (Uranine) Using Karl Fischer Titration

Group(s): Carboxylic Acid Salts, Cosmetic Products + Compounds, Pharmaceutical Products + Compounds
Keywords: Dehydration reaction, Pharmaceutical, Titrations

Peer-Reviewed Papers

References

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Permeation through phospholipid bilayers, skin-cell penetration, plasma stability, and CD spectra of α- and β-oligoproline derivatives. Kolesinska B, Podwysocka DJ, Rueping MA, et al. Chem. Biodivers. 10(1), 1-38, (2013)

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Experimental verification of Faradaic charging in ac electrokinetics. Ng WY Biomicrofluidics 3(2), 22405, (2009)

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Association between perifoveal hyperfluorescence and serous retinal detachment in diabetic macular edema. Murakami T, Uji A, Ogino K, et al. Ophthalmology 120(12), 2596-603, (2013)

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Fluorescein angiographic observations of peripheral retinal vessel growth in infants after intravitreal injection of bevacizumab as sole therapy for zone I and posterior zone II retinopathy of prematurity. Tahija SG, Hersetyati R, Lam GC, et al. Br. J. Ophthalmol. 98(4), 507-12, (2014)

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Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver. Ryan JC, Dunn KW, and Decker BS Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(12), R1488-92, (2014)

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Bisphosphonate uptake in areas of tooth extraction or periapical disease. Cheong S, Sun S, Kang B, et al. J. Oral Maxillofac. Surg. 72(12), 2461-8, (2014)

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Reliability of 4 clinical grading systems for corneal staining. Sook Chun Y and Park IK Am. J. Ophthalmol. 157(5), 1097-102, (2014)

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Error in Missing Journal Club Designation in: Sensitivity and Specificity of a Point-of-Care Matrix Metalloproteinase 9 Immunoassay for Diagnosing Inflammation Related to Dry Eye. JAMA Ophthalmol. 131(3), 364, (2013)

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Blood-brain barrier transport of an essential amino acid after cerebral ischemia reperfusion injury. Suzuki T, Miyazaki Y, Ohmuro A, et al. Acta Neurochir. Suppl. 118, 297-302, (2013)

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Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis. Pereira Morais MP, Marshall D, Flower SE, et al. Sci. Rep. 3, 1437, (2013)

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Oral fluorescein staining in mucous membrane pemphigoid. Somerville TF, Stewart RM, Leong HL, et al. JAMA Ophthalmol. 131(3), 395, (2013)

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Two time point versus 4 time point data acquisition in aqueous humor flow rate determinations by fluorophotometry. Fischer KM, Ward DA, and Hendrix DV J. Glaucoma 23(9), 613-5, (2014)

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Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. Yangyuoru PM, Hammonds-Odie L, and Mwongela SM Methods Mol. Biol. 984, 329-40, (2013)

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Fluorescein fluorescence use in the management of intracranial neoplastic and vascular lesions: a review and report of a new technique. Lane BC and Cohen-Gadol AA Curr. Drug Discov. Technol. 10(2), 160-9, (2013)

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What is the value of incorporating tear osmolarity measurement in assessing patient response to therapy in dry eye disease? Amparo F, Jin Y, Hamrah P, et al. Am. J. Ophthalmol. 157(1), 69-77.e2, (2014)

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Oatp58Dc contributes to blood-brain barrier function by excluding organic anions from the Drosophila brain. Seabrooke S and O'Donnell MJ Am. J. Physiol. Cell Physiol. 305(5), C558-67, (2013)

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Release of antimicrobial peptides from electrospun nanofibres as a drug delivery system. Eriksen TH, Skovsen E, and Fojan P J. Biomed. Nanotechnol. 9(3), 492-8, (2013)

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Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: direct evidence for load-induced fluid flow. Price C, Zhou X, Li W, et al. J. Bone Miner Res. 26(2), 277-85, (2011)

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Corneal staining characteristics in limited zones compared with whole cornea documentation for the detection of dry eye subtypes. Fenner BJ and Tong L Invest. Ophthalmol. Vis. Sci. 54(13), 8013-9, (2013)

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Up-to-date expert opinion referencing the best evidence available on intraoperative cerebrospinal fluid leak during endoscopic sinus surgery. Al-Reefy H and Hopkins C Clin. Otolaryngol. 38(1), 48-53, (2013)

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Quantitative visualization of passive transport across bilayer lipid membranes. Grime JM Proc. Natl. Acad. Sci. U. S. A. 105(38), 14277-82, (2008)

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Tear film images and breakup analyzed using fluorescent quenching. King-Smith PE, Ramamoorthy P, Braun RJ, et al. Invest. Ophthalmol. Vis. Sci. 54(9), 6003-11, (2013)

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Factors predicting the ocular surface response to desiccating environmental stress. Alex A, Edwards A, Hays JD, et al. Invest. Ophthalmol. Vis. Sci. 54(5), 3325-32, (2013)

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Impact of fluorescein on the antimicrobial efficacy of photoactivated riboflavin in corneal collagen cross-linking. Richoz O, Gatzioufas Z, Francois P, et al. J. Refract. Surg. 29(12), 842-5, (2013)

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An inexpensive blue filter for fluorescein-assisted repair of cerebrospinal fluid rhinorrhea. Singh NP and Roberts DN Laryngoscope 124(5), 1103-5, (2014)

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A novel brain neurovascular unit model with neurons, astrocytes and microvascular endothelial cells of rat. Xue Q, Liu Y, Qi H, et al. Int. J. Biol. Sci. 9(2), 174-89, (2013)

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Fluorescein analogue xanthene-9-carboxylic acid: a transition-metal-free CO releasing molecule activated by green light. Antony LA, Slanina T, Šebej P, et al. Org. Lett. 15(17), 4552-5, (2013)

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Sodium fluorescein-guided resection under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery--a feasibility study. Schebesch KM, Proescholdt M, Höhne J, et al. Acta Neurochir. (Wien.) 155(4), 693-9, (2013)

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Dodecyl and octyl esters of fluorescein as protonophores and uncouplers of oxidative phosphorylation in mitochondria at submicromolar concentrations. Shchepinova MM, Denisov SS, Kotova EA, et al. Biochim. Biophys. Acta 1837(1), 149-58, (2014)

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C-type natriuretic peptide modulates permeability of the blood-brain barrier. Bohara M, Kambe Y, Nagayama T, et al. J. Cereb. Blood Flow Metab. 34(4), 589-96, (2014)

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Technical principles and neurosurgical applications of fluorescein fluorescence using a microscope-integrated fluorescence module. Rey-Dios R and Cohen-Gadol AA Acta Neurochir. (Wien.) 155(4), 701-6, (2013)

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An evidence-based analysis of Australian optometrists' dry eye practices. Downie LE, Keller PR, and Vingrys AJ Optom. Vis. Sci. 90(12), 1385-95, (2013)

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Probe-based confocal laser endomicroscopy of the urinary tract: the technique. Chang TC, Liu JJ, and Liao JC J. Vis. Exp. (71), e4409, (2013)

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Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions. López-Miguel A, Tesón M, Martín-Montañez V, et al. Am. J. Ophthalmol. 157(4), 788-798.e2, (2014)

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Movement of internal canalicular orifice in association with blinking: direct observation after dacryocystorhinostomy. Kakizaki H, Takahashi Y, Miyazaki H, et al. Am. J. Ophthalmol. 156(5), 1051-1055.e1, (2013)

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Tear film breakup and structure studied by simultaneous video recording of fluorescence and tear film lipid layer images. King-Smith PE, Reuter KS, Braun RJ, et al. Invest. Ophthalmol. Vis. Sci. 54(7), 4900-9, (2013)

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Halogenation generates effective modulators of amyloid-Beta aggregation and neurotoxicity. Wong HE, Irwin JA, and Kwon I PLoS ONE 8(2), e57288, (2013)

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Noncovalent binding of xanthene and phthalocyanine dyes with graphene sheets: the effect of the molecular structure revealed by a photophysical study. Zhang XF, Liu SP, and Shao XN Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 113, 92-9, (2013)

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Transcription, translation, and function of lubricin, a boundary lubricant, at the ocular surface. Schmidt TA, Sullivan DA, Knop E, et al. JAMA Ophthalmol. 131(6), 766-76, (2013)

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Effects of amino acids enriched tears substitutes on the cornea of patients with dysfunctional tear syndrome. Aragona P, Rania L, Roszkowska AM, et al. Acta Ophthalmol. 91(6), e437-44, (2013)

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Safety and efficacy of oral fluorescein angiography in detecting macular edema in comparison with spectral-domain optical coherence tomography. Barteselli G, Chhablani J, Lee SN, et al. Retina (Philadelphia, Pa.) 33(8), 1574-83, (2013)

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A novel fluorescent lipid probe for dry eye: retrieval by tear lipocalin in humans. Yeh PT, Casey R, and Glasgow BJ Invest. Ophthalmol. Vis. Sci. 54(2), 1398-410, (2013)

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Characteristics of the low density corneal endothelial monolayer. Singh JS, Haroldson TA, and Patel SP Exp. Eye Res. 115, 239-45, (2013)

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Effects of a topically applied 2% delta-9-tetrahydrocannabinol ophthalmic solution on intraocular pressure and aqueous humor flow rate in clinically normal dogs. Fischer KM, Ward DA, and Hendrix DV Am. J. Vet. Res. 74(2), 275-80, (2013)

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Fluorescence quenching of uranine on confeito-like Au nanoparticles. Ujihara M, Dang NM, and Imae T J. Nanosci. Nanotechnol. 14(7), 4906-10, (2014)

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Efficacy of 3 toothbrush treatments on plaque removal in orthodontic patients assessed with digital plaque imaging: a randomized controlled trial. Erbe C, Klukowska M, Tsaknaki I, et al. Am. J. Orthod. Dentofacial Orthop. 143(6), 760-6, (2013)

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Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. Amparo F, Dastjerdi MH, Okanobo A, et al. JAMA Ophthalmol. 131(6), 715-23, (2013)

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Topical rebamipide treatment for superior limbic keratoconjunctivitis in patients with thyroid eye disease. Takahashi Y, Ichinose A, and Kakizaki H Am. J. Ophthalmol. 157(4), 807-812.e2, (2014)

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KRT12 mutations and in vivo confocal microscopy in two Japanese families with Meesmann corneal dystrophy. Ogasawara M, Matsumoto Y, Hayashi T, et al. Am. J. Ophthalmol. 157(1), 93-102.e1, (2014)

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Short-term effects of overnight orthokeratology on corneal epithelial permeability and biomechanical properties. Yeh TN, Green HM, Zhou Y, et al. Invest. Ophthalmol. Vis. Sci. 54(6), 3902-11, (2013)

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Retcam fluorescein gonioangiography: a new modality for early detection of angle neovascularization in diabetic retinopathy. Azad R, Arora T, Sihota R, et al. Retina (Philadelphia, Pa.) 33(9), 1902-7, (2013)

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Determination of torasemide by fluorescence quenching method with some dihalogenated fluorescein dyes as probes. Cui Z, Liu S, Liu Z, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114, 547-52, (2013)

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Comparison of methods for visualizing blood on dark surfaces. Finnis J, Lewis J, and Davidson A Sci. Justice 53(2), 178-86, (2013)

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Synthesis and in vitro characterisation of ifenprodil-based fluorescein conjugates as GluN1/GluN2B N-Methyl-D-aspartate receptor antagonists. Dhilly M, Becerril-Ortega J, Colloc'h N, et al. ChemBioChem. 14(6), 759-69, (2013)

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Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells. Takata F, Dohgu S, Matsumoto J, et al. Biochem. Biophys. Res. Commun. 433(4), 586-90, (2013)

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Effects of rhinacanthin-C on function and expression of drug efflux transporters in Caco-2 cells. Wongwanakul R, Vardhanabhuti N, Siripong P, et al. Fitoterapia 89, 80-5, (2013)

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Intravenous mannitol does not increase blood-brain barrier permeability to inert dyes in the adult rat forebrain. Chen KB, Wei VC, Yen LF, et al. Neuroreport 24(6), 303-7, (2013)

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Effects of oral administration of anti-inflammatory medications on inhibition of paracentesis-induced blood-aqueous barrier breakdown in clinically normal cats. Rankin AJ, Sebbag L, Bello NM, et al. Am. J. Vet. Res. 74(2), 262-7, (2013)

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Application of a microplate-based ORAC-pyrogallol red assay for the estimation ofantioxidant capacity: First Action 2012.03. Ortiz R, Antilén M, Speisky H, et al. J. AOAC Int. 95(6), 1558-61, (2012)

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Noncontact high-resolution ultra-wide-field oral fluorescein angiography in premature infants with retinopathy of prematurity. Fung TH, Muqit MM, Mordant DJ, et al. JAMA Ophthalmol. 132(1), 108-10, (2014)

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Autologous fibrin membrane combined with solid platelet-rich plasma in the management of perforated corneal ulcers: a pilot study. Alio JL, Rodriguez AE, Martinez LM, et al. JAMA Ophthalmol. 131(6), 745-51, (2013)

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Voluntary blinking and use of 0.25% dye on fluorescein dye disappearance test. Kim C, Lee MJ, and Khwarg SI Can. J. Ophthalmol. 48(2), 99-103, (2013)

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A simple and effective calibration method to determine the accuracy of liquid-handling nano-dispenser devices. Rodríguez-Puente S, Linacero-Blanco J, and Guasch A Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69(Pt 3), 336-41, (2013)

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Red-free light for measurement of intraocular pressure using Goldmann applanation tonometer without fluorescein. Ghoneim EM Eur. J. Ophthalmol. 24(1), 84-7, (2014)

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The value of tear osmolarity as a metric in evaluating the response to dry eye therapy in the clinic and in clinical trials. Amparo F, Hamrah P, Schaumberg DA, et al. Am. J. Ophthalmol. 157(4), 915-6, (2014)

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Multiple muscular ventricular septal defects: use of fluorescein dye to identify residual defects. Mathew T, Kundan S, Abdulsamad MI, et al. Ann. Thorac. Surg. 97(1), e27-8, (2014)

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The value of tear osmolarity as a metric in evaluating the response to dry eye therapy in the clinic and in clinical trials. Pepose JS, Sullivan BD, Foulks GN, et al. Am. J. Ophthalmol. 157(1), 4-6.e1, (2014)

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Fluorescence and Electronic Action Spectroscopy of Mass-Selected Gas-Phase Fluorescein, 2',7'-Dichlorofluorescein and 2',7'-Difluorofluorescein Ions. Yao H, Jockusch RA. J. Phys. Chem. A, (2013)

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Merck 14,4159

Beil. 19,IV,2904

Corp MSDS 1 (1), 1688:C / FT-IR 1 (2), 1010:B / FT-IR 2 (3), 4147:C / IR-Spectra (2), 1269:G / IR-Spectra (3), 1473:B / RegBook 1 (2), 2793:B / Sax 6, 1426 / Sigma FT-IR 1 (2), 147:A / Stains and Dyes Ref, 375 / Structure Index 1, 444:A:5

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