30399 Fluka

Cytosine β-D-arabinofuranoside

≥99.0% (HPLC)

Synonym: (β-D-Arabinofuranosyl)cytosine, Ara-C, Arabinocytidine, Arabinosylcytosine, Cytarabine, Cytosine arabinoside


assay   ≥99.0% (HPLC)
optical activity   [α]20/D +158±2°, c = 1% in H2O
solubility   H2O: soluble50 mg/mL, clear, colorless
Gene Information   human ... POLB(5423)
mouse ... Cda(72269)


Biochem/physiol Actions

Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.

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Cytosine β-<SC>D</SC>-arabinofuranoside

crystalline, ≥90% (HPLC)

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