Norfloxacin

Papers

Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent. Yoshikazu Asahina et al J. Med. Chem. 48, 3443-6, (2005)

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A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. Noel J de Souza et al J. Med. Chem. 48, 5232-42, (2005)

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Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. Chengxin Zhi et al J. Med. Chem. 48, 7063-74, (2005)

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Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives. Alireza Foroumadi et al Bioorg. Med. Chem. Lett. 15, 4488-92, (2005)

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Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. Chengxin Zhi et al J. Med. Chem. 49, 1455-65, (2006)

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Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. Jason A Wiles et al J. Med. Chem. 49, 39-42, (2006)

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Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety. Alireza Foroumadi et al Bioorg. Med. Chem. Lett. 16, 3499-503, (2006)

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Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives. Somnath Nag et al Bioorg. Med. Chem. Lett. 16, 3824-8, (2006)

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Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis). Giovanni Appendino et al J. Nat. Prod. 69, 251-4, (2006)

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Polyacylated oligosaccharides from medicinal Mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus. Rogelio Pereda-Miranda et al J. Nat. Prod. 69, 406-9, (2006)

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An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Peng R Chen et al Nat. Chem. Biol. 2, 591-5, (2006)

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Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. Philippe Villain-Guillot et al J. Med. Chem. 50, 4195-204, (2007)

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N-caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors. Serge Michalet et al Bioorg. Med. Chem. Lett. 17, 1755-8, (2007)

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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains. John J M Wiener et al Bioorg. Med. Chem. Lett. 17, 2718-22, (2007)

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Synthesis and antimicrobial evaluation of guanylsulfonamides. Pratik R Patel et al Bioorg. Med. Chem. Lett. 17, 6610-4, (2007)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications. Hervé Nicoloff et al Antimicrob. Agents Chemother. 51, 1293-303, (2007)

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Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients. Anita Reinhardt et al Antimicrob. Agents Chemother. 51, 1341-50, (2007)

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Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. Nuno Mendonça et al Antimicrob. Agents Chemother. 51, 1946-55, (2007)

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PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coli. Yongfang Li et al Antimicrob. Agents Chemother. 51, 2092-9, (2007)

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Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Bruno Périchon et al Antimicrob. Agents Chemother. 51, 2464-9, (2007)

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Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. Vincent Cattoir et al Antimicrob. Agents Chemother. 51, 2650-1, (2007)

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Plasmid-mediated quinolone resistance determinant QnrB4 identified in France in an Enterobacter cloacae clinical isolate coexpressing a QnrS1 determinant. Vincent Cattoir et al Antimicrob. Agents Chemother. 51, 2652-3, (2007)

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Effect of anaerobic growth on quinolone lethality with Escherichia coli. Muhammad Malik et al Antimicrob. Agents Chemother. 51, 28-34, (2007)

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Therapeutic effect of nisin Z on subclinical mastitis in lactating cows. Junqiang Wu et al Antimicrob. Agents Chemother. 51, 3131-5, (2007)

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An early response to environmental stress involves regulation of OmpX and OmpF, two enterobacterial outer membrane pore-forming proteins. Myrielle Dupont et al Antimicrob. Agents Chemother. 51, 3190-8, (2007)

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Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus. Carmen E DeMarco et al Antimicrob. Agents Chemother. 51, 3235-9, (2007)

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Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. Astrid Pérez et al Antimicrob. Agents Chemother. 51, 3247-53, (2007)

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New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Kunikazu Yamane et al Antimicrob. Agents Chemother. 51, 3354-60, (2007)

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Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. Emily S Pfeiffer et al Antimicrob. Agents Chemother. 51, 3410-2, (2007)

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In vitro susceptibilities of Mycoplasma putrefaciens field isolates. N T Antunes et al Antimicrob. Agents Chemother. 51, 3452-4, (2007)

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Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. S V Lynch et al Antimicrob. Agents Chemother. 51, 3650-8, (2007)

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Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Sonia K Morgan-Linnell et al Antimicrob. Agents Chemother. 51, 4205-8, (2007)

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Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin. Michelle D Brazas et al Antimicrob. Agents Chemother. 51, 4276-83, (2007)

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Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. María Paula Quiroga et al Antimicrob. Agents Chemother. 51, 4466-70, (2007)

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First characterization of fluoroquinolone resistance in Streptococcus suis. Jose Antonio Escudero et al Antimicrob. Agents Chemother. 51, 777-82, (2007)

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Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus. Céline Vidaillac et al Antimicrob. Agents Chemother. 51, 831-8, (2007)

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Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Zhi Yong Xiao et al J. Nat. Prod. 70, 1779-82, (2007)

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Tetramic and tetronic acids: an update on new derivatives and biological aspects. Rainer Schobert et al Bioorg. Med. Chem. 16, 4203-21, (2008)

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Antimicrobial and cytotoxic arylazoenamines. Part III: antiviral activity of selected classes of arylazoenamines. Michele Tonelli et al Bioorg. Med. Chem. 16, 8447-65, (2008)

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Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents. S D Joshi et al Eur. J. Med. Chem. 43, 1989-96, (2008)

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Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. Rajesh G Kalkhambkar et al Eur. J. Med. Chem. 43, 2178-88, (2008)

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Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. Kunikazu Yamane et al Antimicrob. Agents Chemother. 52, 1564-6, (2008)

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Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa. Hayssam Khalil et al Antimicrob. Agents Chemother. 52, 1635-41, (2008)

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Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Alita A Miller et al Antimicrob. Agents Chemother. 52, 2806-12, (2008)

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ISEcp1-mediated transposition of qnrB-like gene in Escherichia coli. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 2929-32, (2008)

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Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Amélie Carrër et al Antimicrob. Agents Chemother. 52, 2950-4, (2008)

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Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate. Javier Sánchez-Céspedes et al Antimicrob. Agents Chemother. 52, 2990-1, (2008)

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Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. Jian-Hua Liu et al Antimicrob. Agents Chemother. 52, 2992-3, (2008)

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Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Feng Long et al Antimicrob. Agents Chemother. 52, 3052-60, (2008)

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RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. Andrew M Bailey et al Antimicrob. Agents Chemother. 52, 3604-11, (2008)

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Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. Vincent Cattoir et al Antimicrob. Agents Chemother. 52, 3801-4, (2008)

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Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia. Kenichiro Shimizu et al Antimicrob. Agents Chemother. 52, 3823-5, (2008)

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Real-time PCR detection of gyrA and parC mutations in Streptococcus pneumoniae. S Page et al Antimicrob. Agents Chemother. 52, 4155-8, (2008)

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Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. Béatrice Berçot et al Antimicrob. Agents Chemother. 52, 4526-7, (2008)

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Reduced Susceptibility of Proteus mirabilis to triclosan. David J Stickler et al Antimicrob. Agents Chemother. 52, 991-4, (2008)

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Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides. Lilia Chérigo et al J. Nat. Prod. 71, 1037-45, (2008)

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Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius. Vangelis Smyrniotopoulos et al J. Nat. Prod. 71, 1386-92, (2008)

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Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. Giovanni Appendino et al J. Nat. Prod. 71, 1427-30, (2008)

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Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Markus Fridén et al J. Med. Chem. 52, 6233-43, (2009)

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Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity. Kuntal Manna et al Bioorg. Med. Chem. Lett. 19, 2688-92, (2009)

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Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Constance Chollet et al Bioorg. Med. Chem. 17, 2512-23, (2009)

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Design, synthesis, antibacterial activity and physicochemical parameters of novel N-4-piperazinyl derivatives of norfloxacin. Gamal el-Din A A Abuo-Rahma et al Bioorg. Med. Chem. 17, 3879-86, (2009)

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7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents. Joëlle Azéma et al Bioorg. Med. Chem. 17, 5396-407, (2009)

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Interaction of drug based binuclear mixed-ligand complexes with DNA. Mohan N Patel et al Bioorg. Med. Chem. 17, 5648-55, (2009)

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Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents. Pradeep Kumar et al Eur. J. Med. Chem. 44, 1853-63, (2009)

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Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. Deepika Sharma et al Eur. J. Med. Chem. 44, 2347-53, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Design, synthesis and in vitro antibacterial/antifungal evaluation of novel 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)quinoline-3-carboxylic acid derivatives. Zhiyi Yu et al Eur. J. Med. Chem. 44, 4726-33, (2009)

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Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents. B P Mallikarjuna et al Eur. J. Med. Chem. 44, 4739-46, (2009)

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Synthesis of 6-aminomethyl derivatives of benzopyran-4-one with dual biological properties: anti-inflammatory-analgesic and antimicrobial. S M Hasan et al Eur. J. Med. Chem. 44, 4896-903, (2009)

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Contribution of oxidative damage to antimicrobial lethality. Xiuhong Wang et al Antimicrob. Agents Chemother. 53, 1395-402, (2009)

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Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. Que-Tien Tran et al Antimicrob. Agents Chemother. 53, 1652-6, (2009)

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Relationships among Ciprofloxacin, Gatifloxacin, Levofloxacin, and Norfloxacin MICs for Fluoroquinolone-Resistant Escherichia coli Clinical Isolates. Lauren Becnel Boyd, Merry J. Maynard, et al. Antimicrob. Agents Chemother. 53, 229-234, (2009)

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Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Sonia K Morgan-Linnell et al Antimicrob. Agents Chemother. 53, 235-41, (2009)

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Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea. Eun Sil Kim et al Antimicrob. Agents Chemother. 53, 2643-5, (2009)

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First detection of plasmid-encoded blaOXY beta-lactamase. J J González-López et al Antimicrob. Agents Chemother. 53, 3143-6, (2009)

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Emergence of quinolone-resistant Bordetella pertussis in Japan. Masayuki Ohtsuka et al Antimicrob. Agents Chemother. 53, 3147-9, (2009)

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Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. Constança Pomba et al Antimicrob. Agents Chemother. 53, 327-8, (2009)

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Mechanisms of resistance in nontyphoidal Salmonella enterica strains exhibiting a nonclassical quinolone resistance phenotype. Marianne Gunell et al Antimicrob. Agents Chemother. 53, 3832-6, (2009)

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CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii. I Roca et al Antimicrob. Agents Chemother. 53, 4013-4, (2009)

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Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. Zuzana Svetlíková et al Antimicrob. Agents Chemother. 53, 4015-8, (2009)

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Characterization of the plasmid-borne quinolone resistance gene qnrB19 in Salmonella enterica serovar Typhimurium. Anna Maria Dionisi et al Antimicrob. Agents Chemother. 53, 4019-21, (2009)

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Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. Kenji Kurokawa et al Antimicrob. Agents Chemother. 53, 4025-7, (2009)

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Antimicrobial susceptibilities of Mycoplasma genitalium strains examined by broth dilution and quantitative PCR. Ryoichi Hamasuna et al Antimicrob. Agents Chemother. 53, 4938-9, (2009)

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High prevalence of CTX-M-type beta-lactamases among clinical isolates of Enterobacteriaceae in Bamako, Mali. Véronique Duval et al Antimicrob. Agents Chemother. 53, 4957-8, (2009)

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Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. Hideaki Maseda et al Antimicrob. Agents Chemother. 53, 5230-5, (2009)

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Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Vijaya Bharathi Srinivasan et al Antimicrob. Agents Chemother. 53, 5312-6, (2009)

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qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. L M Cavaco et al Antimicrob. Agents Chemother. 53, 603-8, (2009)

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Antibacterial diterpenes from Plectranthus ernstii. Michael Stavri et al J. Nat. Prod. 72, 1191-4, (2009)

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Bioactive pyridine-N-oxide disulfides from Allium stipitatum. Gemma O'Donnell et al J. Nat. Prod. 72, 360-5, (2009)

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Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Ranjana Pathania et al Nat. Chem. Biol. 5, 849-56, (2009)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. Kin Y Tam et al J. Med. Chem. 53, 392-401, (2010)

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Synthesis, antibacterial and antifungal activities of some carbazole derivatives. Fei-Fei Zhang et al Bioorg. Med. Chem. Lett. 20, 1881-4, (2010)

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Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents. Abugafar M L Hossion et al Bioorg. Med. Chem. Lett. 20, 5349-52, (2010)

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Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles. Amol V Gadakh et al Bioorg. Med. Chem. Lett. 20, 5572-6, (2010)

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Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives. Mehul M Patel et al Bioorg. Med. Chem. Lett. 20, 6324-6, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. G V Suresh Kumar et al Eur. J. Med. Chem. 45, 2063-74, (2010)

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Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: inhibitory activity against bacteria and fungi. Manjula Patil et al Eur. J. Med. Chem. 45, 2981-6, (2010)

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Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1. Mohsen M Aly et al Eur. J. Med. Chem. 45, 3365-73, (2010)

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Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. Bo Fang et al Eur. J. Med. Chem. 45, 4388-98, (2010)

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Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. G V Suresh Kumar et al Eur. J. Med. Chem. 45, 5120-9, (2010)

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Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity. Zhen-Hua Chen et al Eur. J. Med. Chem. 45, 5739-43, (2010)

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Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives. Shanmugam Srinivasan et al Eur. J. Med. Chem. 45, 6101-5, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. Anna Fàbrega et al Antimicrob. Agents Chemother. 54, 1218-25, (2010)

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Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. Mirva Lehtopolku et al Antimicrob. Agents Chemother. 54, 1232-6, (2010)

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Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone. Victor Kuete et al Antimicrob. Agents Chemother. 54, 1749-52, (2010)

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Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Matthew G Blango et al Antimicrob. Agents Chemother. 54, 1855-63, (2010)

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In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. Brian J Morrow et al Antimicrob. Agents Chemother. 54, 1955-64, (2010)

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Many chromosomal genes modulate MarA-mediated multidrug resistance in Escherichia coli. Cristian Ruiz et al Antimicrob. Agents Chemother. 54, 2125-34, (2010)

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Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii. Il Kwon Bae et al Antimicrob. Agents Chemother. 54, 3068-9, (2010)

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The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system. Takehiko Mima et al Antimicrob. Agents Chemother. 54, 3113-20, (2010)

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Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. Sébastien Coyne et al Antimicrob. Agents Chemother. 54, 333-40, (2010)

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Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. Jürgen A Bohnert et al Antimicrob. Agents Chemother. 54, 3770-5, (2010)

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Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. Hidemasa Nakaminami et al Antimicrob. Agents Chemother. 54, 4107-11, (2010)

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Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. Jingjing Zhao et al Antimicrob. Agents Chemother. 54, 4219-24, (2010)

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Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin. Jun Okuda et al Antimicrob. Agents Chemother. 54, 4917-9, (2010)

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Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. Girija Dhamdhere et al Antimicrob. Agents Chemother. 54, 5366-8, (2010)

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Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population. J A Severin et al Antimicrob. Agents Chemother. 54, 5413-7, (2010)

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Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. Julien Brillault et al Antimicrob. Agents Chemother. 54, 543-5, (2010)

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Characterization of small ColE-like plasmids mediating widespread dissemination of the qnrB19 gene in commensal enterobacteria. Lucia Pallecchi et al Antimicrob. Agents Chemother. 54, 678-82, (2010)

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Prevalence and clonal characterization of Streptococcus pyogenes clinical isolates with reduced fluoroquinolone susceptibility in Spain. Milagrosa Montes et al Antimicrob. Agents Chemother. 54, 93-7, (2010)

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Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. Wei Wang et al J. Nat. Prod. 73, 1815-20, (2010)

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Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents. Abugafar M L Hossion et al J. Med. Chem. 54, 3686-703, (2011)

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Preparation and antibacterial evaluation of decarboxylated fluoroquinolones. Son T Nguyen et al Bioorg. Med. Chem. Lett. 21, 5961-3, (2011)

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Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. Jigar A Makawana et al Bioorg. Med. Chem. Lett. 21, 6166-9, (2011)

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Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: structure-activities relationships of polysubstituted triazoles. D Linares et al Bioorg. Med. Chem. Lett. 21, 6751-5, (2011)

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Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus. Naresh Sunduru et al Eur. J. Med. Chem. 46, 1232-44, (2011)

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Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents. Xiao-Fang Liu et al Eur. J. Med. Chem. 46, 3469-73, (2011)

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Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities. Yi-Yi Zhang et al Eur. J. Med. Chem. 46, 4391-402, (2011)

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New fluorine-containing hydrazones active against MDR-tuberculosis. Eva Vav?íková et al Eur. J. Med. Chem. 46, 4937-45, (2011)

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1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. Tarunkumar Nanjibhai Akhaja et al Eur. J. Med. Chem. 46, 5573-9, (2011)

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In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. A Briales et al Antimicrob. Agents Chemother. 55, 1266-9, (2011)

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Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. Mark I Garvey et al Antimicrob. Agents Chemother. 55, 190-6, (2011)

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Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis. Efstathia Ioannou et al J. Nat. Prod. 74, 213-22, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. Sandeep Kumar Sharma et al Eur. J. Med. Chem. 48, 16-25, (2012)

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Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents. Li-Li Xu et al Eur. J. Med. Chem. 48, 174-8, (2012)

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Merck 14,6700