Sulfadiazine

Papers

Synthesis and in vitro study of novel Mannich bases as antibacterial agents. Sheela Joshi et al Bioorg. Med. Chem. Lett. 15, 221-6, (2005)

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Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity. Rômulo P Tenório et al Bioorg. Med. Chem. Lett. 15, 2575-8, (2005)

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QSAR study on the antibacterial activity of some sulfa drugs: building blockers of Mannich bases. Dheeraj Mandloi et al Bioorg. Med. Chem. Lett. 15, 405-11, (2005)

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Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9. Charles W Locuson et al J. Med. Chem. 50, 1158-65, (2007)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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Synthesis, structure analysis, and antibacterial activity of some novel 10-substituted 2-(4-piperidyl/phenyl)-5,5-dioxo[1,2,4]triazolo[1,5-b][1,2,4]benzothiadiazine derivatives. Ahmed Kamal et al Bioorg. Med. Chem. Lett. 17, 5400-5, (2007)

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Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide. Sheela Joshi et al Bioorg. Med. Chem. Lett. 17, 645-8, (2007)

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Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents. Ahmed Kamal et al Bioorg. Med. Chem. 15, 1004-13, (2007)

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Recent developments in fragment-based drug discovery. Miles Congreve et al J. Med. Chem. 51, 3661-80, (2008)

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Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase. Young Ah Kim et al J. Med. Chem. 51, 3934-45, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids. Thiago M de Aquino et al Bioorg. Med. Chem. 16, 446-56, (2008)

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Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Márcia Valéria Gaspar de Araújo et al Bioorg. Med. Chem. 16, 5788-94, (2008)

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Computational aqueous solubility prediction for drug-like compounds in congeneric series. Lei Du-Cuny et al Eur. J. Med. Chem. 43, 501-12, (2008)

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In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone. Pascale Meneceur et al Antimicrob. Agents Chemother. 52, 1269-77, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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In vivo and in vitro anti-leishmanial activities of 4-nitro-N-pyrimidin- and N-pyrazin-2-ylbenzenesulfonamides, and N2-(4-nitrophenyl)-N1-propylglycinamide. M Auxiliadora Dea-Ayuela et al Bioorg. Med. Chem. 17, 7449-56, (2009)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. Sara Thulin Hedberg et al Antimicrob. Agents Chemother. 53, 1561-6, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability. Kin Y Tam et al J. Med. Chem. 53, 392-401, (2010)

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Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. Young Ah Kim et al Bioorg. Med. Chem. 18, 3403-12, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles. André P Liesen et al Eur. J. Med. Chem. 45, 3685-91, (2010)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold. Martin Krátký et al Eur. J. Med. Chem. 50, 433-40, (2012)

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Merck 14,8903

Beil. 25,IV,2097

Corp MSDS 1 (2), 3195:A / FT-IR 2 (3), 3872:A / FT-NMR 1 (3), 392:A / RegBook 1 (2), 2587:C / Sax 6, 2338 / Sigma FT-IR 1 (1), 713:D / Structure Index 1, 409:C:4