Griseofulvin

Papers

Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans. Paul Klausmeyer et al J. Nat. Prod. 68, 1300-2, (2005)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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N- and S-alpha-l-arabinopyranosyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. First synthesis and biological evaluation. Nasser S A M Khalil et al Eur. J. Med. Chem. 42, 1193-9, (2007)

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Synthetic studies on novel benzimidazolopeptides with antimicrobial, cytotoxic and anthelmintic potential. Rajiv Dahiya et al Eur. J. Med. Chem. 42, 772-98, (2007)

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Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues. Vinod Mathew et al Eur. J. Med. Chem. 42, 823-40, (2007)

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Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy. Albrecht Serfling et al Antimicrob. Agents Chemother. 51, 3672-6, (2007)

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Sean Ekins et al Drug Metab. Dispos. 35, 493-500, (2007)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. Rajesh G Kalkhambkar et al Eur. J. Med. Chem. 43, 2178-88, (2008)

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Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles. Mari Sithambaram Karthikeyan et al Eur. J. Med. Chem. 43, 25-31, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells. Mads H Rønnest et al J. Med. Chem. 52, 3342-7, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. Hatem A Abdel-Aziz et al Eur. J. Med. Chem. 44, 4985-97, (2009)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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Synthesis, characterization, and in vitro antimicrobial activities of 5-alkenyl/hydroxyalkenyl-2-phenylamine-1,3,4-oxadiazoles and thiadiazoles. Nida N Farshori et al Bioorg. Med. Chem. Lett. 20, 1933-8, (2010)

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Synthesis and antimicrobial activity of novel fluorine containing 4-(substituted-2-hydroxybenzoyl)-1H-pyrazoles and pyrazolyl benzo[d]oxazoles. Amol V Gadakh et al Bioorg. Med. Chem. Lett. 20, 5572-6, (2010)

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Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives. Mehul M Patel et al Bioorg. Med. Chem. Lett. 20, 6324-6, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis, in vitro antibacterial and antifungal evaluations of new alpha-hydroxyphosphonate and new alpha-acetoxyphosphonate derivatives of tetrazolo [1, 5-a] quinoline. Amol H Kategaonkar et al Eur. J. Med. Chem. 45, 1128-32, (2010)

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Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives. Ahmet Ozdemir et al Eur. J. Med. Chem. 45, 2080-4, (2010)

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Transition metal complexes of a new hexadentate macroacyclic N2O4-donor Schiff base: inhibitory activity against bacteria and fungi. Manjula Patil et al Eur. J. Med. Chem. 45, 2981-6, (2010)

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Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach. Amol H Kategaonkar et al Eur. J. Med. Chem. 45, 3142-6, (2010)

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Conventional and microwave assisted synthesis of some new N-[(4-oxo-2-substituted aryl -1, 3-thiazolidine)-acetamidyl]-5-nitroindazoles and its antimicrobial activity. Apoorva Upadhyay et al Eur. J. Med. Chem. 45, 3541-8, (2010)

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Pharmacological evaluation and characterizations of newly synthesized 1,2,4-triazoles. Navin B Patel et al Eur. J. Med. Chem. 45, 4293-9, (2010)

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Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines. Nimesh R Kamdar et al Eur. J. Med. Chem. 45, 5056-63, (2010)

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Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives. Pradeepkumar M Ronad et al Eur. J. Med. Chem. 45, 85-9, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. Zeba N Siddiqui et al Bioorg. Med. Chem. Lett. 21, 2860-5, (2011)

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Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus. Jigar A Makawana et al Bioorg. Med. Chem. Lett. 21, 6166-9, (2011)

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The synthesis of xanthones, xanthenediones, and spirobenzofurans: Their antibacterial and antifungal activity. Justin J Omolo et al Bioorg. Med. Chem. Lett. 21, 7085-8, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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A facile, one-pot synthesis, characterization and antimicrobial activity of o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids. Nida N Farshori et al Eur. J. Med. Chem. 46, 1433-8, (2011)

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Synthesis and identification of ?-aryloxyquinolines and their pyrano[3,2-c]chromene derivatives as a new class of antimicrobial and antituberculosis agents. Divyesh C Mungra et al Eur. J. Med. Chem. 46, 4192-200, (2011)

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Synthesis, pharmacological evaluation and docking studies of coumarin derivatives. B Sandhya et al Eur. J. Med. Chem. 46, 4696-701, (2011)

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1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. Tarunkumar Nanjibhai Akhaja et al Eur. J. Med. Chem. 46, 5573-9, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells. Mads H Rønnest et al J. Med. Chem. 55, 652-60, (2012)

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Merck 14,4549

Beil. 18,V,5,150