Glycine

Papers

1. Cryoenzymology: the study of enzyme catalysis at subzero temperatures. A.L. Fink, M.A. Geeves Meth. Enzymol. 63, 336, (1979)

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2. New experimental approaches to the isoelectric fractionation of cells. J.K. McGuire et al. J. Chromatogr. A 194, 323, (1980)

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3. Theory of protein solubility. Arakawa, T. and Timasheff, S.N. Meth. Enzymol. 114, 49, (1985)

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Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway. X.L. Jin et al Biol. Reprod. 80, 286-94, (2008)

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Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca. Eric J. Dimise et al Proc. Natl. Acad. Sci. U. S. A. 105, 15311-6, (2008)

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Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5′-phosphate cofactor. Hoffman, H.E., et al. J. Med. Chem. 52, 6032-41, (2009)

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Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. Balvinder S Vig et al J. Med. Chem. 49, 3636-44, (2006)

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3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J. Med. Chem. 49, 5571, (2006)

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Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for glycine and gamma-aminobutyric acid receptors. Maria Luisa Gelmi et al J. Med. Chem. 50, 2245-8, (2007)

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Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor. Anders A Jensen et al J. Med. Chem. 50, 4616-29, (2007)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxic. Mech. Methods 18, 217-27, (2008)

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Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex. Stephan Urwyler et al J. Med. Chem. 52, 5093-107, (2009)

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A class of novel conjugates of substituted purine and Gly-AA-OBzl: synthesis and evaluation of orally analgesic activity. Guifeng Kang et al Bioorg. Med. Chem. Lett. 20, 6157-60, (2010)

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Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1). Iris Thondorf et al Bioorg. Med. Chem. 19, 6409-18, (2011)

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Aminomethyltetrazoles as potential inhibitors of the ?-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation. Eva S Schaffert et al Bioorg. Med. Chem. 19, 6492-504, (2011)

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Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. Silke Hack et al Eur. J. Med. Chem. 46, 1483-98, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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4. CRC Handbook of Microbiology Cleveland, Ohio 4, 1, (1974)

Merck 14,4491

Beil. 4,IV,2349

Fieser 1,412

Corp MSDS 1 (1), 1786:D / FT-IR 1 (1), 563:A / FT-IR 2 (1), 898:A / FT-NMR 1 (1), 867:A / Fenaroli, 307 / IR-Spectra (2), 302:A / IR-Spectra (3), 338:A / NMR-Reference 2 (1), 481:A / RegBook 1 (1), 645:A / Sax 6, 1481 / Sigma FT-IR 1 (1), 176:B / Structure Index 1, 94:A:1