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52512 Fluka

1,1,1,3,3,3-Hexafluoro-2-propanol

puriss., ≥99.0% (GC)

Synonym: HFP, Hexafluoroisopropanol

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Properties

Related Categories Alcohols, Building Blocks, C2 to C6, Chemical Synthesis, Organic Building Blocks,
grade   puriss.
assay   ≥99.0% (GC)
impurities   ≤0.1% water
refractive index   n20/D 1.275(lit.)
bp   59 °C(lit.)
mp   −4 °C(lit.)
density   1.596 g/mL at 25 °C(lit.)

Description

Other Notes

Solvent with high solubilizing potential for peptides and peptide intermediates1

This product has been replaced by 105228-ALDRICH | 1,1,1,3,3,3-Hexafluoro-2-propanol ≥99%

Price and Availability

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1,1,1,3,3,3-<WBR>Hexafluoro-<WBR>2-<WBR>propanol

for GC derivatization, ≥99.8%

1,1,1,3,3,3-<WBR>Hexafluoro-<WBR>2-<WBR>propanol

eluent additive for LC-MS

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
C
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36/37/39-45
RIDADR 
UN 2922 6.1(8) / PGII
WGK Germany 
2
RTECS 
UB6450000

Protocols & Articles

Peer-Reviewed Papers

References

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1. M. Narita et al. Bull. Chem. Soc. Jpn. 61, 281, (1988)

Thioester-isocyanides: versatile reagents for the synthesis of cycle-tail peptides. Rotstein BH, Winternheimer DJ, Yin LM, et al. Chem. Commun. (Camb.) 48(31), 3775-7, (2012)

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Hexafluoroisopropanol induces amyloid fibrils of islet amyloid polypeptide by enhancing both hydrophobic and electrostatic interactions. Yanagi K, Ashizaki M, Yagi H, et al. J. Biol. Chem. 286(27), 23959-66, (2011)

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A stepwise solvent-promoted SNi reaction of α-D-glucopyranosyl fluoride: mechanistic implications for retaining glycosyltransferases. Chan J, Tang A, and Bennet AJ J. Am. Chem. Soc. 134(2), 1212-20, (2012)

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Electrostatic force microscopy of self-assembled peptide structures. Clausen CH, Dimaki M, Panagos SP, et al. Scanning 33(4), 201-7, (2011)

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Toxic role of K+ channel oxidation in mammalian brain. Cotella D, Hernandez-Enriquez B, Wu X, et al. J. Neurosci. 32(12), 4133-44, (2012)

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Sustainable release of vancomycin, gentamicin and lidocaine from novel electrospun sandwich-structured PLGA/collagen nanofibrous membranes. Chen DW, Hsu YH, Liao JY, et al. Int. J. Pharm. 430(1-2), 335-41, (2012)

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Microfabricated electrospun collagen membranes for 3-D cancer models and drug screening applications. Hartman O Biomacromolecules 10(8), 2019-32, (2009)

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Evaluation of mobile phase composition for enhancing sensitivity of targeted quantification of oligonucleotides using ultra-high performance liquid chromatography and mass spectrometry: application to phosphorothioate deoxyribonucleic acid. Chen B and Bartlett MG J. Chromatogr. A 1288, 73-81, (2013)

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Charged diphenylalanine nanotubes and controlled hierarchical self-assembly. Wang M, Du L, Wu X, et al. ACS Nano 5(6), 4448-54, (2011)

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The effect of organic modifiers on electrospray ionization charge-state distribution and desorption efficiency for oligonucleotides. Chen B, Mason SF, and Bartlett MG J. Am. Soc. Mass Spectrom. 24(2), 257-64, (2013)

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Hydrogen-bond strengthening upon photoinduced electron transfer in ruthenium-anthraquinone dyads interacting with hexafluoroisopropanol or water. Hankache J, Hanss D, and Wenger OS J. Phys. Chem. A 116(13), 3347-58, (2012)

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Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. Downing TL, Wang A, Yan ZQ, et al. J. Control. Release 161(3), 910-7, (2012)

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Role of aromatic interactions in amyloid formation by islet amyloid polypeptide. Tu LH and Raleigh DP Biochemistry 52(2), 333-42, (2013)

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Silk fibroin-based scaffolds for bone regeneration. Kuboyama N, Kiba H, Arai K, et al. J. Biomed. Mater. Res. B. Appl. Biomater. 101(2), 295-302, (2013)

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Large increase of the lifetime of a charge-separated state in a molecular triad induced by hydrogen-bonding solvent. Hankache J and Wenger OS Chemistry 18(21), 6443-7, (2012)

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Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. Lioudyno MI, Broccio M, Sokolov Y, et al. PLoS ONE 7(4), e35090, (2012)

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Preparation and properties of electrospun soy protein isolate/polyethylene oxide nanofiber membranes. Xu X, Jiang L, Zhou Z, et al. ACS Appl. Mater. Interfaces 4(8), 4331-7, (2012)

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Human dental pulp progenitor cell behavior on aqueous and hexafluoroisopropanol based silk scaffolds. Zhang W, Ahluwalia IP, Literman R, et al. J. Biomed. Mater. Res. A 97(4), 414-22, (2011)

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Two fluoroalcohols as components of basic buffers for liquid chromatography electrospray ionization mass spectrometric determination of antibiotic residues. Kipper K, Herodes K, Leito I, et al. Analyst 136(21), 4587-94, (2011)

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Fluoroalcohols as novel buffer components for basic buffer solutions for liquid chromatography electrospray ionization mass spectrometry: retention mechanisms. Kipper K, Herodes K, and Leito I J. Chromatogr. A 1218(45), 8175-80, (2011)

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Determination of sevoflurane and its metabolite hexafluoroisopropanol by direct injection of human plasma into gas chromatography-tandem mass spectrometry. Kubincová J, Szabóová A, Podolec P, et al. J. Chromatogr. A 1219, 173-6, (2012)

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Hexafluoroisopropanol induces self-assembly of β-amyloid peptides into highly ordered nanostructures. Pachahara SK, Chaudhary N, Subbalakshmi C, et al. J. Pept. Sci. 18(4), 233-41, (2012)

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Production of identical retention times and mass spectra for {delta}9-tetrahydrocannabinol and cannabidiol following derivatization with trifluoracetic anhydride with 1,1,1,3,3,3-hexafluoroisopropanol*. Andrews R and Paterson S J. Anal. Toxicol. 36(1), 61-5, (2012)

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Infrared spectra, vibrational assignment, and ab initio calculations for N-bromo-hexafluoro-2-propanimine. Panikar SS, Guirgis GA, Sheehan TG, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 90, 118-24, (2012)

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Prevention of amyloid-β fibril formation using antibodies against the C-terminal region of amyloid-β1-40 and amyloid-β1-42. Montañés M, Casabona D, Sarasa L, et al. J. Alzheimers Dis. 34(1), 133-7, (2013)

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Bacterial amyloids. Zhou Y, Blanco LP, Smith DR, et al. Methods Mol. Biol. 849, 303-20, (2012)

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Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins. Lopes DH, Sinha S, Rosensweig C, et al. Methods Mol. Biol. 849, 11-21, (2012)

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Aldrich MSDS 1, 1023:C / Corp MSDS 1 (1), 1847:C / FT-IR 1 (1), 179:A / FT-IR 2 (1), 259:A / FT-NMR 1 (1), 279:C / IR-Spectra (2), 102:D / IR-Spectra (3), 110:D / NMR-Reference 2 (1), 167:B / RegBook 1 (1), 181:D / Sax 6, 1513 / Sigma FT-IR 1 (1), 1341:C / Structure Index 1, 24:C:2 / Vapor Phase 3, 259:D

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